研究主題 Current research topics
Exploring microbial endocrinology in human health and disease through multi-omics approaches
生物體內的固醇類荷爾蒙參與許多重要的生理功能,包括調控代謝、免疫反應、甚至是胚胎的發育,我們其中一個研究主題即是探討生物體中的腸道微生物或是表皮微生物是如何影響宿主之固醇類荷爾蒙含量與其分子機制,並進而探討這些微生物在宿主健康或疾病中扮演的角色。
The steroidal hormones, including progestin, estrogen, androgen, and mineralocorticoids, play essential roles in regulating physiological functions, metabolism, the immune system, and even embryonic development. One of our research focuses is to explore the role of microbiota in regulating the content of steroidal hormones and the underlying molecular mechanisms. We also hope that the isolated microbes can be further developed into probiotics or live biotherapeutic products (LBPs).
計畫執行 Projects
國科會 解析芽孢凝集桿菌BRCASC3菌株新穎之雙氫睪酮代謝路徑及緩解高雄性素血症相關症狀的潛力和機制 (2025/08/01 ~ 2028/07/31)
清大火種計畫 模擬隱形眼鏡中的微生物交互作用後棘阿米巴抗藥性和感染能力對角膜炎的影響評估 (2024/01/01 ~ 2024/12/31)