Journal Papers
Po-Hsiang Wang*, Tien-Yu Wu*, Yi-Lung Chen, Ronnie G Gicana, Tzong-Huei Lee, Mei-Jou Chen, Tsun-Hsien Hsiao, Mei-Yeh Jade Lu, Yi-Li Lai, Tzi-Yuan Wang, Jeng-Yi Li, Yin-Ru Chiang. (2025 Mar). Bacterial estrogenesis without oxygen: Wood–Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere. Proc Natl Acad Sci U S A. 122: e2422930122.
Mei-Jou Chen, Chia-Hung Chou, Tsun-Hsien Hsiao, Tien-Yu Wu, Chi-Ying Li, Yi-Lung Chen, Kuang-Han Chao, Tzong-Huei Lee, Ronnie G Gicana, Chao-Jen Shih, Guo-Jie Brandon-Mong, Yi-Li Lai, Po-Ting Li, Yu-Lin Tseng, Po-Hsiang Wang, Yin-Ru Chiang. (2024 Nov). Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development. Gut Microbes 16: 2424911.
Tsun-Hsien Hsiao, Po-Hao Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Chen-Wei Li, Masae Horinouchi, Toshiaki Hayashi, Wael Ismail, Menghsiao Meng, Yi-Lung Chen, and Yin-Ru Chiang. (2023 Jun). Harnessing microbial phylum-specific molecular markers for assessment of environmental estrogen degradation. Science of the Total Environment 896: 165152.
Tsun-Hsien Hsiao, Chia-Hong Chou, Yi-Lung Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Tzong-Huei Lee, Tien-Yu Wu, Po-Ting Li, Chen-Wei Li, Yi-Li Lai, Yu-Lin Tseng, Chao-Jen Shih, Po-Hao Chen, Mei-Jou Chen, and Yin-Ru Chiang. (2023, Feb). Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut. Gut Microbes 15: 2183685.
Wan-Yu Chi, Tsun-Hsien Hsiao, Gang-Hui Lee, I-Hsiu Su, Bing-Hung Chen, Ming-Jer Tang, Tzu-Fun Fu. (2022, Jul). The cooperative interplay among inflammation, necroptosis and YAP-pathway contributes to the folate deficiency-induced liver cells enlargement. Cellular and molecular life sciences. 79, 397.
Ronnie G.Gicana, Fang-I Yeh, Tsun-Hsien Hsiao, Yin-Ru Chiang, Jhen-Sheng Yan, Po-Hsiang Wang (2022, Jun). Valorization of fish waste and sugarcane bagasse for Alcalase production by Bacillus megaterium via a circular bioeconomy model. Journal of the Taiwan Institute of Chemical Engineers, 135:104358.
Tsun-Hsien Hsiao*, Tzong-Huei Lee*, Meng-Rong Chuang, Po-Hsiang Wang, Menghsiao Meng, Masae Horinouchi, Toshiaki Hayashi, Yi-Lung Chen, Yin-Ru Chiang (2022, Mar). Identification of essential β-oxidation genes and corresponding metabolites for oestrogen degradation by actinobacteria. Microbial Biotechnology. 15(3):949-966.
Tsun-Hsien Hsiao*, Gang-Hui Lee*, Yi-Sheng Chang, Bing-Hung Chen, Tzu-Fun Fu (2021, Jun). The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Frontiers in Cell and Developmental Biology, 9, 1583.
Tsun‐Hsien Hsiao*, Yi‐Lung Chen*, Menghsiao Meng, Meng‐Rong Chuang, Masae Horinouchi, Toshiaki Hayashi, Po‐Hsiang Wang, Yin‐Ru Chiang (2021, May). Mechanistic and phylogenetic insights into actinobacteria‐mediated oestrogen biodegradation in urban estuarine sediments. Microbial Biotechnology, 14(3), 1212-1227.
Gang-Hui Lee, Chia-Lin Chang, Wen-Tai Chiu, Tsun-Hsien Hsiao, Po-Yuan Chen, Kuan-Chieh Wang, Cheng-Hsiang Kuo, Bing-Hung Chen, Guey-Yueh Shi, Hua-Lin Wu, Tzu-Fun Fu (2019, Dec). A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. Journal of biomedical science. 26: 60.
Hung-Chi Tu, Meng-Yun Lin, Chia-Yang Lin, Tsun-Hsien Hsiao, Zhi-Hong Wen, Bing-Hung Chen, Tzu-Fun Fu (2019, Oct). Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish. Ecotoxicology and environmental safety. 182:109380.
Hung-Chi Tu, Gang-Hui Lee, Tsun-Hsien Hsiao, Tseng-Ting Kao, Tzu-Ya Wang, Jen-Ning Tsai, Tzu-Fun Fu (2017, Nov). One crisis, diverse impacts—Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae. PLOS ONE, 12(11): e0188585.
Tseng-Ting Kao, Chia-Yi Chu, Gang-Hui Lee, Tsun-Hsien Hsiao, Nai-Wei Cheng, Nan-Shan Chang, Bing-Hung Chen, Tzu-Fun Fu (2014, Nov). Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish - Implication in neural tube defects and Alzheimer's diseases. Neurobiology of Disease, 71, 234-44. (IF: 5.202, 2013)
Wen-Ni Chang, Gang-Hui Lee, Tseng-Ting Kao, Cha-Ying Lin, Tsun-Hsien Hsiao, Jen-Ning Tsai, Bing-Hung Chen, Yau-Hung Chen, Hsin-Ru Wu, Huai-Jen Tsai, Tzu-Fun Fu. (2014, Apr). Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Biochimica et Biophysica Acta (BBA) - General Subjects, 1840(7), 2340-2350.
Tsun-Hsien Hsiao, Chia-Jen Lin, Yi-Shao Chung, Gang-Hui Lee, Tseng-Ting Kao, Wen-Ni Chang, Bing-Hung Chen, Jan-Jong Hung, Tzu-Fun Fu. (2014, Feb). Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. Molecular and Cellular Biology, 34(3), 498-509.
Gang-Hui Lee, Shian-Ying Sung, Wen-Ni Chang, Tseng-Ting Kao, Hung-Chi Tu, Tsun-Hsien Hsiao, Martin K Safo, Tzu-Fun Fu. (2012, Nov). Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. Disease Models and Mechanisms, 5(6), 785-95.
Chia-Jen Lin, Tsun-Hsien Hsiao, Yi-Shao Chung, Wen-Ni Chang, Trai-Ming Yeh, Bing-Hung Chen, Tzu-Fun Fu. (2010, Mar). Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1. Protein Expression and Purification, 76(1), 36-43.
(*, Equal contribution)
Patents
US provisional patent: Yin-Ru Chiang, Mei-Jou Chen, Tsun-Hsien Hsiao, Chia-Hung Chou. APPLICATIONS OF ANDROGEN-METABOLIZING LACTIC ACID BACTERIA. 63/516,305
Technology Transfer
新型功能益生菌開發：利用可代謝雄性素的乳酸菌來改善宿主之雄性素過多症 (合約編號:113-10TC-04)