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"STUDYING STRUCTURE & MECHANISM OF MEMBRANE TRANSPORT"
"STUDYING STRUCTURE & MECHANISM OF MEMBRANE TRANSPORT"
CLC CHANNEL AND TRANSPORTER
CLC CHANNEL AND TRANSPORTER
Cryo-EM structure and functional characterization of CLC family proteins.
Activation mechanism of inner and outer gates of CLC protein.
Voltage- and pH-dependent gating mechanism.
Astrocytic Membrane proteins
Astrocytic Membrane proteins
Activation and ion transport mechanism of BEST1 channel.
Functional and structural modulation of BEST1 channel by the interacting protein.
PTM of MLC1 protein and their functional consequences.
Structural determination and elucidating functional role of MLC1 protein.
TREM2, a risk factor of Alzheimer's disease
TREM2, a risk factor of Alzheimer's disease
STRUCTURE-FUNCTION OF TREM2 SIGNALING COMPLEX
Structural determination of full-length human TREM2 with its signaling effect, DAP12.
Identification and characterization of TREM2-interacting proteins.
Development of TREM2-specific therapeutic antibodies.
CALCIUM AND CALCIUM-ACTIVATED POTASSIUM CHANNELS
CALCIUM AND CALCIUM-ACTIVATED POTASSIUM CHANNELS
CLUSTERING AND FUNCTIONAL COUPLING OF TWO DISTINCT CHANNELS
Super-resolution imaging and electrophysiological characterization of ion channel couplings.
EQUIPMENTS
EQUIPMENTS
Patch-clamp system 1
Patch-clamp system 2
Planar lipid bilayer system 1
Planar lipid bilayer system 2 (Orbit-mini)
FPLC-MALS-RI system
FPLC with fluorescence detector
Isothermal Titration Calorimeter
Bio-layer interferometry system
Ion-flux recording system
Crystal drop setting robot
Liquid handler
crystal incubators
low-pressure purification system
Protein purification cart 1
Protein purification cart 2
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