Address unmet medical needs by developing innovative therapeutic strategies based on bioactive natural products.
Our research initially focused on intractable skin diseases, particularly atopic dermatitis and psoriasis. Through our research in psychodermatology, we found that mice with chronic skin conditions exhibit increased susceptibility to stress and are prone to developing depressive and anxiety-like behaviors. This prompted us to extend our research to behavioral analyses of depression, anxiety, and hyperactivity in stress-induced animal models.
Stress-related depression and anxiety disorders
Depression as a comorbidity in chronic diseases
Treatment-resistant depression (TRD)
Sleep disorders (Insomnia)
Binge eating disorder (BED) and food addiction
Development of Anti-pollution Materials Using Traditional Korean Medicine (TKM) Knowledge Information (한의약지식정보를 활용한 안티폴루션 소재 개발연구). 2017 ~ 2018. Ministry of Health and Welfare
Development of External Preparations Based on TKM Ingredient Combinations (한의성분조합 외용제 개발연구). 2017 ~ 2019. Ministry of Science and ICT
Identification of Stress-induced Atopic Dermatitis Aggravation Mechanisms and Development of Novel TKM Treatments via Brain-Skin Axis Regulation (스트레스에 의한 아토피피부염 악화 기전 규명 및 Brain-Skin Axis 조절을 통한 새로운 한의약 치료기술 개발). 2019 ~ 2021. Ministry of Science and ICT
Development of Intranasal TKM Formulations for the Treatment of Mental Disorders (정신질환 치료용 비강투여 한약제제 개발 연구). 2022 ~ 2024. Ministry of Health and Welfare
Establishment of Research Infrastructure for Traditional Scents and Development of Therapeutic Technologies (Promotion of Stress Resilience and Treatment of Depression) (전통 향 연구기반 구축 및 치료 기술 개발 (스트레스 회복탄력성 촉진 및 우울증 치료)). 2021 ~ 2028. Ministry of Education
Development of TKM Treatments for Orexin-targeted Sleep Disorders: A Study on Utilization Strategies for Health Insurance-covered Herbal Preparations (오렉신 타겟 수면장애 한의약 치료기술 개발: 건강보험 한약제제 활용 방안 연구). 2024 ~ 2026. Ministry of Health and Welfare
Development of Cyperi Rhizoma-derived Nasal Inhalation Therapeutics for the Control of Treatment-Resistant Depression (TRD) (치료저항성 우울증(TRD) 제어를 위한 향부자 유래 비강 흡입형 치료제 개발). 2026 ~ 2028. Ministry of Health and Welfare
Composition for preventing or treating psoriasis comprising herb mixtures (혼합 생약 추출물을 유효성분으로 포함하는 건선 예방 또는 치료용 약학적 조성물). Reg No. 10-2197858-0000
Pharmaceutical composition comprising extract of Eucommiae coretex for prevention or treatment of muscle wasting disease (두충 추출물을 포함하는 근육 소모 관련 질환 예방 또는 치료용 약학적 조성물). Reg No. 10-1614205-0000
PHARMACEUTICAL COMPOSITION FOR TREATING ATOPIC DERMATITIS COMPRISING FRACTION OF Cyperus rotundus EXTRACT (향부자 유래 발렌센을 유효성분으로 포함하는 아토피 피부염 치료용 약학적 조성물). Reg No. 10-1789446-0000
A Composition for Improving Skin Diseases and Enhancing Skin Barrier including Formononetin (포모노네틴을 포함하는 피부질환 개선 및 피부장벽 강화용 조성물). Reg No. 10-1893323-0000
A Composition for Improving Skin Diseases and Enhancing Skin Barrier including Baicalein (바이칼레인을 포함하는 피부질환 개선 및 피부장벽 강화용 조성물). Reg No. 10-1920450-0000
Pharmaceutical Composition for Preventing Or Treating Of Dry Eye Comprising Extract Of Saposhnikoviae Radix, Galla Rhois, Lophatheri Herba, And Gentianae Scabrae Radix (방풍, 오배자, 죽엽 및 용담 추출물을 유효성분으로 포함하는 건성안 예방 또는 치료용 약학적 조성물). Reg No. 10-2094696-0000
Skin external composition for preventing, improving or treating Psoriasis (건선 예방, 개선 또는 치료용 피부 외용제 조성물). Reg No. 10-2354028-0000
Pharmaceutical composition comprising extract of herb mixture for treating or preventing inflammatory bowel disease (혼합 생약제 추출물을 유효성분으로 함유하는 염증성 장질환 예방 또는 치료용 약학적 조성물). Reg No. 10-1710730-0000
Compositions for Preventing and Treating Dry Eye Syndrome (안구건조증 예방 및 치료용 조성물). Reg No. 10-1932862-0000
The composition comprising extracts from fruits of Foeniculum vulgare for enhancing function of skin barrier (회향 열매 추출물을 유효성분으로 포함하는 피부장벽 기능 강화용 조성물). Reg No. 10-1780111-0000
Pharmacological composition for nasal administration comprising guibi-tang-gagam extract for preventing or treating depression or anxiety as an active ingredient (우울증 또는 불안증 예방 또는 치료를 위한 귀비탕가감 추출물을 유효성분으로 포함하는 비강투여용 약학 조성물). Reg No. 10-2955894-0000