The Baht Lab uses mouse models to investigate the process of bone repair and cellular differentiation. The research themes within the lab currently involve cellular metabolism, inflammation, and aging.
Tibial fracture models are used to assess in vivo bone healing in response to injury and in vitro tissue culture systems are used to investigate osteoblastic differentiation. Three mouse-model systems are used: parabiosis, bone marrow transplantation, and tissue culture.
Recent efforts have generated a list of candidates which play a role in bone healing and play a role in osteoblastic differentiation at both the cellular level and within the whole-organism. These candidates are currently being studied using both our in vivo and in vitro systems.