All the laboratory’s publications can be found in the following repositories:

Recent publications (last 5 years)

2026

Flores G, Zamora-Ursulo MA, Manjarrez E, Morales-Medina JC, Tendilla-Beltrán H (2026). Dendritic spine research: Next frontier in the age of artificial intelligence. Neural Reg Res, 10.4103/NRR.NRR-D-25-01345. Advance online publication. https://doi.org/10.4103/NRR.NRR-D-25-01345

Flores G, Apam-Castillejos DJ, Edwards H, Magdaleno-Madrigal VM, Nacher J, Tendilla-Beltrán H, Srivastava LK (2026). Thalamic reticular nucleus in the pathophysiology of schizophrenia. Neural Reg Res, 10.4103/NRR.NRR-D-25-00928. Advance online publication. https://doi.org/10.4103/NRR.NRR-D-25-00928

Mendoza CR, Aguilar-Hernández L, Apam-Castillejos DJ, Vázquez-Hernández AJ, Díaz A, Tendilla-Beltrán H, Flores G, de la Cruz-López F (2026). Chronic ad libitum ethanol exposure impairs corticolimbic and cerebellar structural neuroplasticity in rats. Neurosci Res Notes, 9(1), 472.1–472.14. https://doi.org/10.31117/neuroscirn.v9i1.472

Cabrera-Pedraza FJ, Apam-Castillejos DJ, de la Cruz-López F, Garcés-Ramírez L, Tendilla-Beltrán H, Flores G (2026). Quetiapine treatment corrects behavioral impairments and promotes neuroplasticity in a neurodevelopmental rat model of schizophrenia. Neuroscience, 592:223-231. https://doi.org/10.1016/j.neuroscience.2025.11.036

2025

Escribano-Cadena Y, Tendilla-Beltrán H, Flores, G (2025). Alterations in dendritic spine plasticity in the prefrontal cortex induced by social play restrictions in male rats. Neuroscience, 583, 23-32. https://doi.org/10.1016/j.neuroscience.2025.07.041

Bravo-González F, Acosta-Hernández ME, Tendilla-Beltrán H, Flores G, García-García F (2025). Effect of chronic sleep restriction on ethanol preference and cortical structural plasticity. Neurobiol Sleep Circadian Rhythms. 18(Suppl), 100126. https://doi.org/10.1016/j.nbscr.2025.100126

Nicolás-Álvarez DE, Luna-Muñoz J, Sandoval-Herrera V, Estrada-Silva MA, Cruz-Rodríguez J, Luna-Viramontes NI, Granados-Rivas B, Silva-Luna G, Torres-Mendoza JN, Tendilla-Beltrán H, Flores G, Garcés-Ramírez L, de la Cruz-López F (2025). Chronic administration of 1, 3-di-o-tolylguanidyne induces catalepsy and reduces immobility responses by clamping and grasping in Wistar rat, evaluation in vivo and in silico. Neurosci Lett, 859-861, 138267. https://doi.org/10.1016/j.neulet.2025.138267

García-Dolores F, Hernández-Torres MA, Fuentes-Medel E, Díaz A, Guevara J, Baltazar-Gaytan E, Aguilar-Hernández L, Nicolini H, Morales-Medina JC, González-Cano SI, de la Cruz F, Gil-Velazco A, Tendilla-Beltrán H, Flores, G (2025). Atrophy and Higher Levels of Inflammatory-Related Markers in the Posterior Cerebellar Lobe Cortex in Chronic Alcohol Use Disorder: A Cross-Sectional Study. Neuropathol Appl Neurobiol, 51(2), e70011. https://doi.org/10.1111/nan.70011

Flores G, Aguilar-Hernández L, García-Dolores F, Nicolini H, Vázquez-Hernández AJ, Tendilla-Beltrán H (2025). Dendritic spine degeneration: a primary mechanism in the aging process. Neural Reg Res, 20(6), 1696-1698. https://doi.org/10.4103/NRR.NRR-D-24-00311

Tendilla-Beltrán H, Pérez-Osornio DL, Apam-Castillejos DJ, Flores G (2025). Atypical antipsychotics improve dendritic spine pathology in temporal lobe cortex neurons in a developmental rodent model of schizophrenia. Behav Brain Res, 478, 115341. https://doi.org/10.1016/j.bbr.2024.115341

Flores G, Reyes-Lizaola S, Aguilar-Hernández L, Gil-Velazco A, Tendilla-Beltrán H, Morales-Medina JC (2025). Role of the amygdala and possible biomarkers in psychiatric disorders. NeuroMarkers, 2(1) 100032. https://doi.org/10.1016/j.neumar.2024.100032

2024

Tendilla-Beltrán H, Aguilar-Alonso P, Hernández-González CA, Baltazar-Gaytán E, Orduña AA, Nicolini H, García-Dolores F and Flores G (2024). Dysregulated zinc homeostasis and microadenomas in the anterior pituitary: pathological insights into suicide risk. Front Psychiatry 15:1446255. https://doi.org/10.3389/fpsyt.2024.1446255

Boyzo Montes de Oca A, Tendilla-Beltrán H, Bringas ME, Flores G, Aceves J (2024). Chronic pramipexole and rasagiline treatment enhances dendritic spine structural neuroplasticity in striatal and prefrontal cortex neurons of rats with bilateral intrastriatal 6-hydroxydopamine lesions. J Chem Neuroanat, 141, 102468. https://doi.org/10.1016/j.jchemneu.2024.102468

Tendilla-Beltrán H, Garcés-Ramírez L, Martínez-Vásquez E, Nakakawa A, Gómez-Villalobos MdeJ, Flores G (2024). Differential effects of neonatal ventral hippocampus lesion on behavior and corticolimbic plasticity in Wistar-Kyoto and Spontaneously Hypertensive rats. Neurochem Res, 49, 959–979. https://doi.org/10.1007/s11064-023-04074-9

Reyes-Lizaola S*, Luna-Zarate U*, Tendilla-Beltrán H*, Morales-Medina JC, Flores G(2024). Structural and biochemical alterations in dendritic spines as key mechanisms for severe mental illnesses. Prog Neuropharmacol Biol Psychiatry. 129, 110876. https://doi.org/10.1016/j.pnpbp.2023.110876

2023

Tendilla-Beltrán H, Martín-Hernández D (2023). Editorial: Non-canonical pathways of psychiatric drugs: beyond their neurotransmitter action. Front Neurosci, 17: 1278748. https://doi.org/10.3389/fnins.2023.1278748

Tendilla-Beltrán H*, Carbajal-Rimoldi LA*, Flores F*, Gómez-Mendoza LE, Loaiza G, Flores G. (2023). Antipsychotics modified COVID-19 prevalence in hospitalized patients diagnosed with mental illnesses. Gen Hosp Psychiatry, 84, 250-252. https://doi.org/10.1016/j.genhosppsych.2023.04.009

Martín-Hernández D, Muñoz-López M, Tendilla-Beltrán H, Caso JR, García-Bueno B, Menchén L, Leza JC. (2023). Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm?. Int J Mol Sci, 24(16), 12634. https://doi.org/10.3390/ijms241612634

Flores-Gómez GD, Apam-Castillejos DJ, Juárez-Díaz I, Fuentes-Medel E, Díaz A, Tendilla-Beltrán H, Flores G. (2023) Aripiprazole attenuates the medial prefrontal cortex morphological and biochemical alterations in rats with neonatal ventral hippocampus lesion. J Chem Neuroanat, 132, 102316. https://doi.org/10.1016/j.jchemneu.2023.102316

García-Dolores F*, Tendilla-Beltrán H*, Flores F, Carbajal-Rimoldi LA, Mendoza-Morales RC, Gómez-Mendoza LE, Vázquez-Hernández AJ, de la Cruz F, Genis-Mendoza AD, Nicolini H, Flores G (2023). Increased suicide rates in Mexico City during the COVID-19 pandemic outbreak: an analysis spanning from 2016 to 2021. Heliyon, 9(6): e16420. https://doi.org/10.1016/j.heliyon.2023.e16420

2022

Apam-Castillejos DJ, Tendilla-Beltrán H, Vázquez-Roque RA, Vázquez-Hernández AJ, Fuentes-Medel E, García-Dolores F, Díaz A, Flores G (2022). Second-generation antipsychotic olanzapine attenuates behavioral and prefrontal cortex synaptic plasticity deficits in a neurodevelopmental schizophrenia-related rat model. J Chem Neuroanat, 125, 102166. https://doi.org/10.1016/j.jchemneu.2022.102166

Martín-Hernández D, Gutiérrez IL, González-Prieto M, MacDowell KS, Robledo-Montaña J, Tendilla-Beltrán H, Calleja-Rodríguez N, Bris AG, Ulecia-Morón C, Moreno B, Caso JR, García-Bueno B, Rodrigues-Mascarenhas S, Marín-Jiménez I, Leza JC, Menchén L (2022). Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub‑chronic stress. Sci Rep 12, 4073. https://doi.org/10.1038/s41598-022-08011-8

Coatl-Cuaya H, Tendilla-Beltrán H, de Jesús-Vásquez LM, Garcés-Ramírez L, Gómez-Villalobos MJ, Flores G (2022). Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats. J Chem Neuroanat, 120, 102061. https://doi.org/10.1016/j.jchemneu.2021.102061

Moreno-Martínez S, Tendilla-Beltrán H, Sandoval V, Flores G, Terrón JA (2022). Chronic restraint stress induces anxiety-like behavior and remodeling of dendritic spines in the central nucleus of the amygdala. Behav Brain Res 416, 113523. https://doi.org/10.1016/j.bbr.2021.113523