The goal of this project is to develop new smart multifunctional hybrids that combine the osteogenesis and angiogenesis effects induced by nano mesoporous active ions containing mesoporous bioactive glasses with the antibacterial activity and good mechanical properties of reduced graphene oxides and with the low temperature induced hardening properties of pluronic copolymers, in an easily administrable, injectable self-setting form for tissue engineering applications in dentistry.
The proposed project is structured in 3 experimental and 1 project management work packages that reunites 12 experimental andoneadministrative objective as follow:
WP1. Preparation, characterization and optimization of nano mesoporous bioactive glasses (nMBG)
O.1 - Synthesis of nMBG’s
O.2 - Physico-chemical characterization of the obtained nMBG’s
O.3 - In vitro testing of nMBG’s
WP2. Preparation, characterization and optimization of graphene oxide nMBG hybrid structures (rGO-nMBG)
O.4 - Synthesis of rGO
O.5 - Physico-chemical characterizations of rGO’s and its preproducts
O.6 - Synthesis of rGO-nMBG
O.7 - Physico-chemical characterizations of rGO-nMBG
O.8 - In vitro testing of rGO-nMBG’s
WP3. Preparation, characterization and optimization of multifunctional injectable P-rGO-nMBG composites
O.9 - Synthesis of injectable P-rGO-nMBG composites
O.10 - Physico-chemical characterizations of P-rGO-nMBG’s
O.11 - In vitro testing of P-rGO-nMBG’s
O.12 - In vivo testing of P-rGO-nMBG’s
WP0. Project strategy and management
O.0 - Project strategy, management, continuous documentation and result dissemination