• Identifier: PN-III-P1-1.1-TE-2021-0388 (Contract. No. TE 26/2022)

• Principal Investigator: CS II Adriana (Vulpoi) LAZAR

• Project’s duration: 24 months (15/05/2022 - 14/05/2024)

• Total budget: 450.000 LEI (~ 91.000 EUR)

• Financing unit: UEFISCDI

• Contractor: Babeș-Bolyai University of Cluj-Napoca

Summary

To realize the concept of Smart multifunctional injectable low-cost engineered nanoBG-rGO-polymer scaffolds for tissue engineering in dentistry we propose within SMILE a multi-step approach with feedback loops. The purposes of this proposed project are (i) to prepare nanoscaled mesoporous bioactive glasses (nMBG) that incorporate ceria as therapeutic agent; (ii) to reduce and functionalize GO with dopamine while simultaneously implementing nMBG anchor deposition on rGO to obtained rGO-nMBG hybrid structures; (iii) to demonstrate the application of this new hybrid structure in self-setting polymer scaffolds with applications in substitution and restoration of oro-maxillo-facial lost tissues.

The goal of this project is to develop new smart multifunctional hybrids that combine the osteogenesis and angiogenesis effects induced by nano mesoporous active ions containing mesoporous bioactive glasses with the antibacterial activity and good mechanical properties of reduced graphene oxides and with the low temperature-induced hardening properties of pluronic copolymers, in an easily administrable, injectable self-setting form for tissue engineering applications in dentistry.

The proposed project is structured on 3 main experimental work Packages objectives:

• -Preparation, characterization and optimization of nano mesoporous bioactive glasses (nMBG)

• - Preparation, characterization and optimization of graphene oxide nMBG hybrid structures (rGO-nMBG)

• - Preparation, characterization and optimization of multifunctional injectable P-rGO-nMBG composites