Embedded Files
Progressive accumulation of circulating CD27−CD28− effector/memory CD8+ T cells in patients with lung cancer blunts responses to immune checkpoint inhibitor therapy
2025, Experimental & Molecular Medicine (EMM), IF 12.9
Enhanced thrombopoiesis supplies PDL1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancer
2025, Journal for ImmunoTherapy of Cancer (JITC), IF 10.3
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy
2025, Cancer Communications, IF 20.1
Immunophenotypic analysis on circulating T cells for early diagnosis of lung cancer
2024, Biomarker Research , IF 9.5
Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation
2024, Nature Communications, IF 14.7
Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon
2021, Nature Communications, IF 14.919
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
2021, Journal for ImmunoTherapy of Cancer, IF 13.751
STAT1 maintains naïve CD8+ T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
2021, Science Advances, IF 14.136
CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
2016, Nature Communications, IF 12.124
Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells
2011, Blood, IF 9.898
T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis
2010, Immunity, IF 24.221
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2
2007, Journal of Experimental Medicine (JEM), IF 16.121
Publications
Kim YJ, Rho KN, Jeong S, Lee GW, Kim HO, Cho HJ, Bae WK, Oh IJ, Lee SW, Cho JH. CD5 Expression Dynamically Changes During the Differentiation of Human CD8+ T Cells Predicting Clinical Response to Immunotherapy. Immune Netw. 2023 Aug;23(4):e35. https://doi.org/10.4110/in.2023.23.e35
Lee GW, Lee SW, Kim J, Ju YJ, Kim HO, Yun CH, Cho JH. Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells. Front Immunol. 2021 Jan 28;11:616898. doi: 10.3389/fimmu.2020.616898. PMID: 33584707; PMCID: PMC7876067.
Ha DH, Chae S, Lee JY, Kim JY, Yoon J, Sen T, Lee SW, Kim HJ, Cho JH, Cho DW. Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent. Biomaterials. 2021 Jan;266:120477. doi: 10.1016/j.biomaterials.2020.120477. Epub 2020 Oct 19. PMID: 33120198.
Lee JY, Kim J, Yi J, Kim D, Kim HO, Han D, Sprent J, Lee YJ, Surh CD, Cho JH. Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells. Front Immunol. 2018 Mar 16;9:437. doi: 10.3389/fimmu.2018.00437. PMID: 29616017; PMCID: PMC5864862.
Cho JH, Sprent J. TCR tuning of T cell subsets. Immunol Rev. 2018 May;283(1):129-137. doi: 10.1111/imr.12646. PMID: 29664578.
Kim J, Lee JY, Cho K, Hong SW, Kim KS, Sprent J, Im SH, Surh CD, Cho JH. Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells. Front Immunol. 2018 Aug 23;9:1907. doi: 10.3389/fimmu.2018.01907. PMID: 30190718; PMCID: PMC6116856.
Kim HO, Cho JH. T Cell's Sense of Self: a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells. Immune Netw. 2017 Aug;17(4):201-213. doi: 10.4110/in.2017.17.4.201. Epub 2017 Aug 23. PMID: 28860950; PMCID: PMC5577298.
Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016 Nov 14;7:13373. doi: 10.1038/ncomms13373. PMID: 27841348; PMCID: PMC5114568.
Nguyen HH, Kim T, Song SY, Park S, Cho HH, Jung SH, Ahn JS, Kim HJ, Lee JJ, Kim HO, Cho JH, Yang DH. Naïve CD8(+) T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment. Sci Rep. 2016 Jun 16;6:28208. doi: 10.1038/srep28208. PMID: 27306834; PMCID: PMC4910083.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J. Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells. Blood. 2011 Jul 7;118(1):116-28. doi: 10.1182/blood-2010-11-317396. Epub 2011 May 3. PMID: 21540458.
Cho JH, Kim HO, Surh CD, Sprent J. T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity. 2010 Feb 26;32(2):214-26. doi: 10.1016/j.immuni.2009.11.014. Epub 2010 Feb 4. PMID: 20137986; PMCID: PMC2830358.
Sprent J, Cho JH, Boyman O, Surh CD. T cell homeostasis. Immunol Cell Biol. 2008 May-Jun;86(4):312-9. doi: 10.1038/icb.2008.12. Epub 2008 Mar 25. PMID: 18362947.
Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med. 2007 Aug 6;204(8):1787-801. doi: 10.1084/jem.20070740. Epub 2007 Jul 30. PMID: 17664294; PMCID: PMC2118670.
Sprent J, Cho JH. Self/non-self discrimination and the problem of keeping T cells alive. Immunol Cell Biol. 2008 Jan;86(1):54-6. doi: 10.1038/sj.icb.7100139. Epub 2007 Dec 11. PMID: 18071359.
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