Pre-prints are manuscripts and other interim research products which have not undergone peer-review and formal acceptance for publication. In 2017 the NIH issued NOT-OD-17-050 to encourage funded investigators to speed the dissemination of tax-payer funded research by citing and claiming pre-prints as products of NIH funding. In 2023, NIH started a pilot program to list pre-prints funded by NIH in PubMed and to upload the manuscripts to PMC if the appropriate sharing license is selected on pre-print submission.

Pre-Prints

2025

Taffe, M.A., Coons, T.R., Doran, T.A., Grant, Y., and Vandewater, S.A. Effects of 6-methyl nicotine in middle aged female rats with a history of nicotine vapor self-administration. bioRxiv, 2025. doi: https://doi.org/10.1101/2025.09.15.676338 (Posted Sept 21, 2025)

Gutierrez, A., Grant, Y., Vandewater, S.A., and Taffe, M.A. Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) Intravenous Self-Administration in Female and Male Rats. bioRxiv, 2025. doi: https://doi.org/10.1101/2025.09.12.675933 (Posted Sept 17, 2025)

2024

Gutierrez, A., and Taffe, M.A. Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats. bioRxiv, 2024. doi: 10.1101/2024.05.06.592492 (Posted May 10, 2024)

Javadi-Paydar, M., Kerr, T.M., and Taffe, M.A. Hyperactivity Induced By Vapor Inhalation of Nicotine in Male and Female Rats. bioRxiv, 2024. doi: 10.1101/2024.02.12.579996 (Posted February 14, 2024)

Nguyen, J.D., Grant, Y., Yang, C., Gutierrez, A., and Taffe, M.A. Δ9-tetrahydrocannabinol (THC) Increases the Rewarding Value of Oxycodone During Self-Administration in Rats. bioRxiv, 2024. doi: 10.1101/2024.01.18.576277 (Posted January 20, 2024)

2023

Nguyen, J.D., Grant, Y., Yang, C., Gutierrez, A., and Taffe, M.A. Oxycodone Self-Administration in Female Rats is Enhanced by Δ9-tetrahydrocannabinol, but not by Cannabidiol, in a Progressive Ratio Procedure. bioRxiv, 2023. doi: 10.1101/2023.10.26.564282 (Posted October 31, 2023) [ PubMed ]

Gutierrez, A., Creehan, K.M., Grant, Y., and Taffe, M.A. Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats. bioRxiv, 2023. doi: 10.1101/2023.09.08.556932 (Posted September 14, 2023) [PubMed]

Gutierrez, A., and Taffe, M.A. Rats Chasing the Dragon: A new heroin inhalation method. bioRxiv, 2023. doi: 10.1101/2023.08.09.552712 (Posted August 14, 2023) [PubMed] [Accepted for publication J Neuro Meth, November 16, 2023.]

2022

Gutierrez, A., Nguyen, J.D., Creehan, K.M., Grant, Y., and Taffe, M.A. Adult consequences of repeated nicotine vapor inhalation in adolescent rats. bioRxiv, 2022. doi: 10.1101/2022.11.17.516984 . [Updated Aug , 2023; Originally posted November 8, 2022.] [ Accepted for Publication Nicotine & Tobacco Research, October 20, 2023]

2021

Gutierrez, A., Harvey, E.L., Creehan, K.M., and Taffe, M.A. The long-term effects of repeated heroin vapor inhalation during adolescence on measures of nociception and anxiety-like behavior in adult Wistar rats. bioRxiv, 2021. Updated September 30, 2022; Originally posted October 8, 2021. doi: https://doi.org/10.1101/2021.10.06.463404 [Accepted for publication, Psychopharmacology, 17 Oct 2022]

Khom, S., Nguyen, J.D., Vandewater, S.A., Grant, Y., Roberto, M., and Taffe, M.A. Self-Administration of entactogen psychostimulants dysregulates GABA and Kappa Opioid Receptor signaling in the central nucleus of the amygdala of female Wistar rats. bioRxiv, 2021. doi: https://doi.org/10.1101/2021.09.24.461477 [ Published Front. Behav. Neurosci., 16 December 2021 | https://doi.org/10.3389/fnbeh.2021.780500 ]

Gutierrez, A., Creehan, K.M., de Guglielmo, G., Roberts, A.J., and Taffe, M.A. Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii). bioRxiv, 2021, Updated July 12, 2021; Originally posted June 07, 2021; doi: https://doi.org/10.1101/2021.06.05.447220 [Accepted for publication, J Exp Anal Behav, Jan 30, 2022.]

Gutierrez, A., Creehan, K.M., Turner, M., Tran, R.N., Kerr, T.M., Nguyen, J.D., and Taffe, M.A. Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine Lobster (Homarus americanus). bioRxiv, 2021, Originally Posted May 25, 2021; Updated June 23, 2021. doi: https://doi.org/10.1101/2021.05.24.445508 [Accepted for publication, Pharmacol Biochem Behav June 23, 2021]

Gutierrez, A., Creehan, K.M., and Taffe, M.A. THC modifies the impact of heroin delivered by vapor inhalation in rats. bioRxiv, 2021, Posted April 27, 2021; doi: https://doi.org/10.1101/2021.04.26.441541 [Accepted for publication, Psychopharmacology, May 27, 2021]

2020

Taffe, M.A., Nguyen, J.D., Vandewater, S.A., Grant, Y., and Dickerson, T.J. Distinguishing the behavioral potencies of α-pyrrolidino-phenone cathinone stimulants. bioRχiv, 2020, Posted December 15, 2020; doi: https://doi.org/10.1101/2020.12.14.422779 [Accepted for publication, Drug Alcohol Depend Jun 08, 2021]

Taffe, M.A., and Gilpin, N.W. Racial Inequity in Federal Grant Funding. PsyArXiv, 2020, Posted December 10, 2020. doi: 10.31234/osf.io/ucb62 [Accepted for Publication, eLife, Jan 17, 2021]

Moore, C.F., Davis, C.M., Harvey, E.L., Taffe, M.A., and Weerts, E.M. Antinociceptive, hypothermic, and appetitive effects of vaped and injected Δ9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex. bioRχiv, 2020, Posted October 08, 2020. doi: https://doi.org/10.1101/2020.10.06.327312 . [Accepted for Publication, Pharmacol Biochem Behav, Jan 13, 2021.]

Gutierrez, A., Creehan, K.M., and Taffe, M.A. A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats. bioRχiv, 2020, Originally posted Sept 04, 2020, Updated Oct 3, 2020. doi: https://doi.org/10.1101/2020.09.03.281857 . [Accepted for publication, J Neurosci Methods, Oct 23, 2020.]

Nguyen, J.D., Creehan, K.M., Grant, Y., Vandewater, S.A., Kerr, T.M. and Taffe, M.A. Explication of CB1 receptor contributions to the hypothermic effects of Δ9-tetrahydrocannabinol (THC) when delivered by vapor inhalation or parenteral injection in rats. bioRχiv, 2020, Posted May 26, 2020 doi: 10.1101/2020.05.22.111468 . [Accepted for publication, Drug Alcohol Depend, Jul 7, 2020.]

Gutierrez, A., Nguyen, J.D., Creehan, K.M., and Taffe, M.A. Female rats self-administer heroin by vapor inhalation. bioRχiv, 2020, Originally posted March 31, 2020, Updated Oct 14, 2020. doi: https://doi.org/10.1101/2020.03.30.016725 . [Accepted for publication, Pharmacology, Biochemistry & Behavior, Oct 15, 2020.]

2019

Javadi-Paydar, M., Creehan, K.M., Kerr, T.M. and Taffe, M.A. Vapor inhalation of cannabidiol (CBD) in rats. bioRχiv, 2019, Originally posted June 04, 2019, Latest update posted: Jul 18, 2019. doi: https://doi.org/10.1101/659250 [Accepted for publication Jul 19, 2019; Pharmacol Biochem & Behav]

Taffe, M.A., Creehan, K.M., Vandewater, S.A., Kerr, T.M. and Cole, M. Effects of Δ9-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats. bioRχiv, 2019, Posted February 05, 2019, doi: https://doi.org/10.1101/541003 [Accepted for publication 03/13/2020; Exp Clin Psychopharmacol]

2018

Nguyen, J.D., Grant, Y. and Taffe, M.A. Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis, Latest Update: April 16, 2021. doi: https://doi.org/10.1101/460048 [Accepted for publication 04/20/2021; Updated as: Paradoxical changes in brain reward status during opioid self-administration in a novel test of the negative reinforcement hypothesis. Updated November 17, 2019. Originally posted as: Intermittent abstinence potentiates oxycodone self-administration under extended access conditions and alters brain reward sensitivity. bioRχiv, 2018, Originally posted November 2, 2018]

Nguyen, J.D., Creehan, K.M., Kerr, T.M. and Taffe, M.A. Lasting effects of repeated Δ9-tetrahydrocannabinol (THC) vapor inhalation during adolescence in male and female rats. Update posted July 24, 2019. doi: https://doi.org/10.1101/426064 [Original title: Repeated Δ9-tetrahydrocannabinol (THC) vapor inhalation during adolescence: Sex differences in acute thermoregulatory tolerance and in feeding during adulthood. bioRχiv, 2018, Originally posted September 25, 2018. ][Accepted for publication 08/29/19; Brit J Pharmacol]

Javadi-Paydar, M., Kerr, T.M., Harvey, E.L., Cole, M., and Taffe, M.A. Effects of Nicotine and THC Vapor Inhalation Administered By An Electronic Nicotine Delivery System (ENDS) In Male Rats. bioRχiv, 2018, Originally posted September 15, 2018. Latest update January 23, 2019. doi: https://doi.org/10.1101/418699 [Accepted for publication 01/26/19; Drug Alcohol Depend]

2017

Nguyen, J.D., Grant, Y., Creehan, K.M., Hwang, C.S., Vandewater, S.A., Janda, K.D., Cole, M. and Taffe, M.A. Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions. bioRχiv, 2017, Originally posted December 23, 2017. Latest update april 5, 2019 doi: https://doi.org/10.1101/239038 [Accepted for publication 04/07/2019, Neuropharmacology]

Nguyen, J.D., Hwang, C.S., Grant, Y., Janda, K.D.. and Taffe, M.A. Prophylactic vaccination protects against the development of oxycodone self-administration. bioRχiv, 2017, Original posted October 27, 2017. Latest update May 22, 2018. doi: https://doi.org/10.1101/210369 [Accepted for publication 06/21/18; Neuropharmacology]

Javadi-Paydar, M., Harvey, E.L., Grant, Y., Vandewater, S.A., Creehan, K.M., Nguyen, J.D., Dickerson, T.J., and Taffe, M.A. Binge-like Acquisition of α-pyrrolidinopentiophenone (α-PVP) Self-Administration in Female Rats. bioRχiv, 2017, Original posted September 20, 2017. Latest update April 19, 2018 doi: https://doi.org/10.1101/191155 [Accepted for publication 06/01/2018, Psychopharmacology]

Nguyen, J.D., Kirson, D., Steinman, M.Q., Patel, R., Khom, S., Varodayan, F.P., Hedges, D.M., Oleata, C.S., Grant, Y., Roberto, M. and Taffe, M.A.Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function. bioRχiv, 2017, Posted August 18, 2017 doi: https://doi.org/10.1101/177899

Nguyen, J.D., Grant, Y., Kerr, T.M., Gutierrez, A., Cole, M., and Taffe, M.A. Tolerance to the Hypothermic and Antinoceptive effects of Δ9-tetrahydrocannabinol (THC) Vapor Inhalation In Rats. bioRχiv, 2017, Posted August 4, 2017. Latest update May 30, 2018. doi: https://doi.org/10.1101/172759 [Accepted for publication 07/18/18; Pharmacology, Biochemistry & Behavior]

Javadi-Paydar, M., Nguyen, J.D., Vandewater, S.A., Dickerson, T.J., and Taffe, M.A. Locomotor and Reinforceing Effects Of Pentedrone, Pentylone and Methylone In Rats. bioRχiv, 2017, Posted July 21, 2017 doi: https://doi.org/10.1101/166579 [Accepted for publication 09/03/2017; Neuropharmacology]

Javadi-Paydar, M., Nguyen, J.D., Kerr, T.M., Grant, Y., Vandewater, S.A., Cole, M., and Taffe, M.A. Effects Of Δ9-THC And Cannabidiol Vapor Inhalation In Male And Female Rats. bioRχiv, 2017, Originally posted April 18, 2017. Latest update March 7, 2018 doi: https://doi.org/10.1101/128173 [Accepted for publication 06/06/2018; Psychopharmacology].

Taffe, M.A. Wheel running increases hyperthermia and mortality rate following 3,4-methylenedioxymethamphetamine (MDMA) in rats. bioRχiv, 2017, Posted April 11, 2017 doi: https://doi.org/10.1101/126706

Aarde, S.M., Huang, P-K and Taffe, M.A. High Ambient Temperature Facilitates The Acquisition Of 3,4-Methylenedioxymethamphetamine (MDMA) Self-Administration. bioRχiv, 2017, Posted April 4, 2017 doi: https://doi.org/10.1101/123828 [Accepted for publication 10/16/2017; Pharmacology, Biochemistry & Behavior]

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