Featured Papers:

Peer-Reviewed Journal Articles

https://www.ncbi.nlm.nih.gov/sites/myncbi/vijay.yadav.1/bibliography/41165524/public/?sort=date&direction=descending

#: Corresponding author

*: Joint first authors

Selected Publications 

1. Baghel M*, Shi S*, Patel H, Velagapudi V, Ali AM#, Yadav VK# (2024) Taurine/chenodeoxycholic acid ratio as a circulating biomarker of insidious vitamin B12 deficiency in humans. bioRxiv

doi: https://doi.org/10.1101/2024.02.15.580499 (Under revision)

2. Singh P*, Gollapalli K*, Mangiola S$, Schranner D$, Yusuf MA$, Chamoli M$, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK#. (2023) Taurine deficiency as a driver of aging. Science. Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. PubMed PMID: 37289866.[ISI Citations: 93] [Altmetric Score: 4001]. 

3. Sharan K, Lewis K, Furukawa T, Yadav VK#. (2017) Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway. J Pineal  Research.  DOI: 10.1111/jpi.12423. [ISI Citations: 101] [Impact factor: 14.8] [Altmetric Score: 32]

4. Lewis K*, Sharan K*, Takumi T, Yadav VK#. (2017) Skeletal Site-specific Changes in Bone Mass in a Genetic Mouse Model for Human 15q11-13 Duplication Seen in Autism. Scientific Reports. In Press. [ISI Citations: 17] [Impact factor: 4.3] [Altmetric Score: 3]

5. Garcia P*, Gonzalez I*, Mottram L*, Leiben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Santhanam B, Sarper N, Clare S, Vassiliou G, Velagapudi V, Dougan G, Yadav VK# (2014) Vitamin B12-dependent taurine synthesis regulates growth and bone mass. J Clin Invest.  124(7):2988-3002. PMID: 24911144 [ISI Citations: 147] [Impact factor: 15.2] [Altmetric Score: 292]. 

All Publications 

43.  Baghel M*, Shi S*, Patel H, Velagapudi V, Ali AM#, Yadav VK# (2024) Taurine/chenodeoxycholic acid ratio as a circulating biomarker of insidious vitamin B12 deficiency in humans. bioRxiv

doi: https://doi.org/10.1101/2024.02.15.580499 (Under revision)

42. Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK#. (2023) Taurine deficiency as a driver of aging. Science. Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. PubMed PMID: 37289866.

41. Mangiola S, Brown R, Berthelet J, Guleria S, Liyanage C, Ostrouska S, Wilcox J, Merdas M, Larsen P F, Bell C, Schroder J, Mielke L, Mariadason J, Chang- Hao Tsao S, Chen Y, Yadav V K, Anderson R L, Vodala S, Merino D, Behren A, Yeo B, Papenfuss AT, Pal B* (2023) The circulating immune cell landscape stratifies metastatic burden in breast cancer patients. bioRxiv doi: https://doi.org/10.1101/2023.11.01.565223  (Under review)

40. Abyadeh M, Yadav VK, Kaya A. (2023) Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development. J Alzheimer’s disease. doi: 10.3233/JAD-230684 PMID: 37638446.

39. Correa Pinto Junior D, Canal Delgado I, Yang H, Clemenceau A, Corvelo A, Narzisi G, Musunuri R, Meyer Berger J, Hendricks LE, Tokumura K, Luo N, Li H, Oury F#, Ducy P#,  Yadav VK#, Li X#, Karsenty G#. (2023) Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring. bioRxiv. 2023 Aug 14:2023.08.11.552969. doi: 10.1101/2023.08.11.552969. Published in final form: EMBO Rep. 2024 Feb;25(2):593-615. doi: 10.1038/s44319-023-00031-3. PMID: 38228788. 

38. Mangiola S, Milton M, Ranathunga N, Li-Wai-Suen CSN, Yang E, Hutchison W, Garnham A, Iskander J, Pal B, Yadav VK, Carey VJ, Morgan M, Bedoui S, Kallies A, Papenfuss AT (2023) Whole-body cell map tracks tissue-specific immune cell accumulation and plasticity loss through aging. 2023-06-08 | bioRxiv DOI: 10.1101/2023.06.08.542671 (Under review)

37. Yadav VK#, Berger JM, Singh P, Nagarajan P, Karsenty G#.(2022) Embryonic osteocalcin signalling determines lifelong adrenal growth and steroidogenesis in the mouse. J Clin Invest Feb 15;132(4):e153752.doi;10.1172/JCI153752.  [ISI Citations: 7] 

36. Singh P*, Telnova S*, Zhou B*, Mohamed AD*, Mello VD*, Wackerhage H, Guo E, Panda AK, Yadav VK# (2021) Maternal vitamin B12 in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring. Am J Physiol Regul Integr Comp Physiol  Mar 24.  doi: 10.1152/ajpregu.00355.2020. [ISI Citations: 2] [Impact factor: 3.6]

35. Chowdhury S, Schulz L, Palmisano B, Berger JM, Singh P, Yadav VK, Ellisgaard H, Hidalgo J, Bruning J, Karsenty G. (2020) Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts. J Clin Invest.  Jun 1;130(6):2888-2902.doi: 10.1172/JCI133572.

34. Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Yadav VK, Rahmouni K, Gao XB, Karsenty G. (2020) Mediation of the Acute Stress Response by the Skeleton. Cell Metab. Sep 4. pii: S1550-4131(19)30441-3. PMID: 31523009

33. Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F (2019) Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature. 2019 Apr;568(7753):541-545.

32. Manglani K, Vijayan V, Pathak C, Khandelwal M, Singh P, Chelappa S, Yadav VK, Surolia A, Gupta S. (2019) Development and Characterization of Supramolecular Calcitonin Assembly and Assessment of its Interactions with the Bone Remodeling Process. Bone May;122:123-135.

31. Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. (2019) Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Mol Metab. 20:38-50. PMID: 30553769

30. Vijay K. Yadav#. (2018) Vitamin B12 as a regulator of bone health. Current Science.  Apr 25;114(8): 1632-38. Review

29. Kunal Sharan, Kirsty Lewis, Takahisa Furukawa, Vijay K. Yadav#. (2017) Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway. J Pineal  Research.  DOI: 10.1111/jpi.12423. In Press. [ISI Citations: 80] [Impact factor: 14.8] [Altmetric Score: 32]

28. Kirsty Lewis*, Kunal Sharan*, Toru Takumi, Vijay K. Yadav#. (2017) Skeletal Site-specific Changes in Bone Mass in a Genetic Mouse Model for Human 15q11-13 Duplication Seen in Autism. Scientific Reports. In Press. [ISI Citations: 13] [Impact factor: 4.3] [Altmetric Score: 3]

27. Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK, Park S, Kim H. (2015) Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nature Communications. 2015 Apr 13;6:6794. [Impact factor: 11.32] [Altmetric Score: 11]

26. Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H. (2015) Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. 2014 Nov 26:en20141687. [Impact factor: 4.72] [Altmetric Score: 1]

25. Garcia P*, Gonzalez I*, Mottram L*, Leiben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Santhanam B, Sarper N, Clare S, Vassiliou G, Velagapudi V, Dougan G, Yadav VK# (2014) Vitamin B12-dependent taurine synthesis regulates growth and bone mass. J Clin Invest.  2014 Jul 1;124(7):2988-3002. PMID: 24911144 [ISI Citations: 100] [Impact factor: 15.2] [Altmetric Score: 90]. Previewed in NEJM; covered in several news outlets.

24. Isabel Gonzalez and Vijay K. Yadav# (2014) Central genes, pathways and modules that regulate bone mass. Arch Biochem Biophys. 2014 Nov 1;561:130-6 [Impact factor: 3.04] 

23. Kunal Sharan, Vijay K. Yadav# (2014) Hypothalamic regulation of bone mass. Best Practice & Research Clinical Endocrinology & Metabolism. 2014 Oct;28(5):713-23 [Impact factor: 4.91]

22. Eleftheria Zeggini, Kalliope Panoutsopoulou, Lorraine Southam, Nigel W Rayner, Aaron G Day-Williams, Margarida C Lopes, Vesna Boraska, Tonu Esko, Evangelos Evangelou, Albert Hofman, Jeanine J Houwing-Duistermaat, Thorvaldur Ingvarsson, Ingileif Jonsdottir, Helgi Jonsson, Hanneke J M Kerkhof, Margreet Kloppenburg, Steff an D Bos, Massimo Mangino, Sarah Metrustry, P Eline Slagboom, Gudmar Thorleifsson, Emma V A Raine, Madhushika Ratnayake, Michelle Ricketts, Claude Beazley, Hannah Blackburn, Suzannah Bumpstead, Katherine S Elliott, Sarah E Hunt, Simon C Potter, So-Youn Shin, Vijay K Yadav, Guangju Zhai, Kate Sherburn, Kate Dixon, Elizabeth Arden, Nadim Aslam, Phillippa-Kate Battley, Ian Carluke, Sally Doherty, Andrew Gordon, John Joseph, Richard Keen, Nicola C Koller, Sheryl Mitchell, Fiona O’Neill, Ellen Paling, Mike R Reed, Fernando Rivadeneira, Diane Swift, Kirsten Walker, Bridget Watkins, Maggie Wheeler, Fraser Birrell, John P A Ioannidis, Ingrid Meulenbelt, Andres Metspalu, Ashok Rai, Donald Salter, Kari Stefansson, Unnur Styrkarsdottir, André G Uitterlinden, Joyce B J van Meurs, arcOGEN Consortium: Kay Chapman, Panos Deloukas, William E R Ollier, Gillian A Wallis, Nigel Arden, Andrew Carr, Michael Doherty, Andrew McCaskie, J Mark Wilkinson, Stuart H Ralston, Ana M Valdes, Tim D Spector, John Loughlin. (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet. 380(9844):815-23 [ISI Citations: 8] [Impact factor: 44.00] [Altmetric Score: 39]

21. H. Inose, B. Zhou, Vijay K Yadav, X. Guo, G Karsenty, P Ducy (2011) Efficacy of serotonin inhibition in mouse models of bone loss. J Bone Miner Res. May 23. doi: 10.1002/jbmr.439 [ISI Citations: 22] [Impact factor: 6.04]

20. Vijay K Yadav*, Frank Oury*, Tiffany Thomas, Ying Wang, Serge Cremers, Rene Hen, Andree Krust, Pierre Chambon, and Gerard Karsenty (2011) Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications. J Exp Med. 2011 Jan 17;208(1):41-52. [ISI Citations: 26] [Impact factor: 13.91]

19. Gerard Karsenty and Vijay K. Yadav (2011) Serotonin regulation of bone mass: Molecular biology and therapeutic implications. Annual Review of Medicine Feb 18;62:323-31 Review [ISI Citations: 18] [Impact factor: 12.92]

18. Vijay K. Yadav#, P. Ducy, and Gerard Karsenty (2010). Serotonin: A new player in the regulation of bone remodelling. Medicographia 32(4):357-63 Review

17. Franck Oury, Vijay K. Yadav, Bin Zhou, X. Sherry Liu, X. Edward Guo, Laurence H. Tecott, Gunther Schutz, Anthony R. Means, Gerard Karsenty (2010) CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010 Oct 15;24(20):2330-42. [ISI Citations: 23] [Impact factor: 12.64]

16. Vijay K. Yadav, Santhanam Balaji, P.S. Suresh, X. Sherry Liu, Zhishan Li, Xin Lu, X. Edward Guo, J. John Mann, Anil K. Balapure, Michael D. Gershon, R. Medhamurthy, Marc Vidal, Gerard Karsenty and Patricia Ducy (2010) Pharmacological inhibition of gut-derived serotonin is a potential bone anabolic treatment for osteoporosis. Nature Medicine Mar;16(3):308-12 [ISI Citations: 141] [Impact factor: 30.35]. 

15. Vijay K. Yadav, Henrique Pierotti Arantes, Elizabete Ribeiro Barros, Marise Lazaretti-Castro and Patricia Ducy (2010) Genetic analysis of Lrp5 function in osteoblast progenitors. Calcified tissue international. May;86(5):382-8 [ISI Citations: 18] [Impact factor: 3.27]

14. Yu Shi, Franck Oury, Vijay K Yadav, J. Wess. X. Sherry Liu, X. Edward Guo, Monzur Murshed, and Gerard Karsenty (2010) Signaling through the muscarinic receptor 3 favors bone mass accrual by decreasing the sympathetic activity. Cell Metabolism, Mar 3;11(3):231-8 [ISI Citations: 20] [Impact factor: 17.35]

13. Morten Frost*, Tom Erenskjold Andersen*, Vijay Yadav, Kim Brixen, Gerard Karsenty, Moustapha Kassem. (2010) Patients with High Bone Mass phenotype due to Lrp5-T253I mutation have low plasma levels of serotonin. J Bone Miner Res. Jan 29;25(3):673-675 [ISI Citations: 30] [Impact factor: 6.04]

12. Eiichi Hinoi, Nan Gao, Dae Young Jung, Vijay K. Yadav, Tatsuya Yoshizawa, Martin G. Myers Jr., Streamson C. Chua Jr., Jason K. Kim, Klaus H. Kaestner and Gerard Karsenty. (2009) An Osteoblast-dependent Mechanism Contributes to the Leptin Regulation of Insulin Secretion. Ann N Y Acad Sci. Sep;1173(s1):E20-E30 Review. [ISI Citations: 28] [Impact factor: 4.72]

11. Vijay K. Yadav*, Franck Oury*, Nina Suda, Zhong-Wu Liu, Xiao-Bing Gao, Cyrille Confavreux, Kristen C Klemenhagen, Kenji F. Tanaka, Jay A. Gingrich, X. Edward Guo, Laurence H. Tecott, J. John Mann, Rene Hen, Tamas L. Horvath, Gerard Karsenty. (2009) A serotonin-dependent mechanism explains leptin regulation of bone mass, appetite and energy expenditure. Cell Sep 4;138(5):976-89. [ISI Citations: 327] [Impact factor: 41.58]. 

10. Vijay K. Yadav# and Gerard Karsenty. (2009) Leptin-dependent co-regulation of bone and energy metabolism. Aging November issue; Volume 1(1) Review [ISI Citations: 15] [Impact factor: 5.68]

9. Vijay K. Yadav and Patricia Ducy. (2010) Lrp5 and bone formation: A serotonin-dependent pathway. Ann N Y Acad Sci. Mar;1192(1):103-9. Review [ISI Citations: 24] [Impact factor: 4.72]

8. Eiichi Hinoi, Nan Gao, Dae Young Jung, Vijay K. Yadav, Tatsuya Yoshizawa, Martin G. Myers Jr., Streamson C. Chua Jr., Jason K. Kim, Klaus H. Kaestner and Gerard Karsenty (2008) The sympathetic tone mediates leptin’s inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol. Dec 29;183(7):1235-42. [ISI Citations: 88] [Impact factor: 10.54]

7. Yu Shi*, Vijay K. Yadav*, Nina Suda, X. Sherry Liu, X. Edward Guo, Martin G. Myers Jr. and Gerard Karsenty (2008) Dissociation of the Neuronal Regulation of Bone Mass and Energy Metabolism by Leptin in vivo. Proc Natl Acad Sci U S A. Dec 23;105(51):20529-33 [ISI Citations: 56] [Impact factor: 11.2] * equal contribution

6. Vijay K. Yadav, Je-Hwang Ryu, Nina Suda, Kenji Tanaka, Jay A. Gingrich, Günther Schütz, Francis H. Glorieux, Cherie Y. Chiang, Jeffrey D Zajac, Karl L. Insogna, J. John Mann, Rene Hen, Patricia Ducy, Gerard Karsenty (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. Nov 28;135(5):825-37. [ISI Citations: 459] [Impact factor: 41.58]. 

5. Vijay K. Yadav and R. Medhamurthy (2006) Dynamic Changes in mitogen activated protein kinases during development, induced-luteolysis and simulated early pregnancy in the bonnet monkey (Macaca radiata): A role of p38 in the regulation of luteal function. Endocrinology 147(4):2018-27 [ISI Citations: 19] [Impact factor: 4.73]

4. Vijay K. Yadav, G. Lakshmi and R. Medhamurthy (2005) Prostaglandin F2a-mediated activation of apoptotic signaling cascades in the corpus luteum during apoptosis: Involvement of caspase activated DNase. J Biol Chem 280(11):10357-67 [ISI Citations: 71] [Impact factor: 5.15]

3. Shalu Verma-Kumar, S. V. Srinivas, P. Muraly, Vijay K. Yadav and Medhamurthy R (2004) Cloning of a Buffalo Prostaglandin F2A Receptor:Changes in its Expression and Concentration in the Buffalo (Bubalus bubalis) Cow Corpus Luteum. Reproduction; 127(6):705-715 [ISI Citations: 9] [Impact factor: 3.90]

2. Vijay K. Yadav, P. Muraly and R. Medhamurthy (2004) Identification of Novel Genes Regulated by the Luteinizing Hormone in the Primate Corpus Luteum: Insights into LH-Responsiveness during the Late Luteal Phase. Mol. Human Reprod. ; 10(9):629-639 [ISI Citations: 29] [Impact factor: 4.02]

1. Vijay K. Yadav, Ranga R. Sudhagar, R. Medhamurthy (2002) Apoptosis During Spontaneous and Prostaglandin F2a-Induced Luteal Regression in Buffalo Cow (Bubalus bubalis): Involvement of Mitogen-Activated Protein Kinases. Biology of Reproduction; 67(3): 752-759 [ISI Citations: 56] [Impact factor: 4.28]

Book Chapters

Parminder Singh, Madhu Baghel, Vijay K. Yadav. (2020) “Stomach–Liver Axis in the Regulation of Bone Mass”. Encylopedia of bone biology, 2020 Doi.org/10.1016/B978-0-12- 801238-3.11233-4

Vijay K. Yadav (2013) Serotonin: The Central Link between Bone Mass and Energy Metabolism. Translational Endocrinology of Bone. Elsevier Press.