SEB Research Group

Systems Engineering for Biotechnology

Research Group

Welcome to the blog of the upcoming research group led by Sebastián Espinel Ríos within the School of Chemical and Bioprocess Engineering at University College Dublin (UCD).

Overview

Our group will work to advance bioproduction by developing tailored computational methods for modeling, optimization, and control, enabling and supporting novel biotechnological applications.

This includes mechanistic, AI-based, and hybrid strategies applied across in-cell, external, and multi-scale levels.

To achieve this, we will take a systems-of-systems approach that integrates concepts from Systems Biology and Process Systems Engineering.

Core research areas

We’ll focus on three core areas in the context of bioprocesses and biosystems:

Digital twin technologies, model reduction, and knowledge transfer.

Methods for multi-level optimization and control, including soft sensors.

Software development for bioprocess digitalization and automation.

Systems Engineering for Biotechnology. A unifying framework integrating Systems Biology (SB) and Process Systems Engineering (PSE). Ref: https://doi.org/10.3389/fsysb.2025.1583534.

📢 Join the group!

A fully funded PhD position will be available in my group, and there are also attractive fellowship schemes that may support additional PhD positions.

Prospective postdoctoral researchers interested in contributing to this vision are also encouraged to get in touch. I am happy to discuss potential fellowship opportunities.

Research-driven MSc students are similarly welcome to explore supervised thesis projects.

Students with an entrepreneurial focus on bioprocess software and digitalization are also welcome to reach out.

Ideal candidate profile

The ideal background may vary depending on the specific project, but generally includes:

A degree in chemical/(bio)process engineering, systems biology, computer science, data science, or related fields.

Prior experience, or at least a strong foundation, in one or more of the following areas: process/metabolic modeling, optimization, control, and AI/machine learning.

For the time being, I am receiving expressions of interest. Candidates can send a complete CV, transcripts, and a motivation letter outlining their background and research interests. 📩 s.espinelrios@gmail.com

Launching in early 2026: the Systems Engineering for Biotechnology research group at University College Dublin, School of Chemical and Bioprocess Engineering, in Ireland’s capital city.