Surya P Aryal, PhD

I am a Research Scientist currently leading research and development efforts in the biotechnology industry. My areas of expertise include biomarker discovery, extracellular vesicles, assay development, optical microscopy, atomic force microscopy, analytical chemistry, single-molecule biophysics, and molecular neurobiology. Previously, I also engaged in higher education and academic research, holding a B.Sc. and M.Sc. in Chemistry from Tribhuvan University and a Ph.D. in Biophysical Chemistry from the University of Kentucky.

My current focus revolves around providing innovative solutions to the life science, biotechnology, and chemical industries, leveraging my interdisciplinary knowledge, skills, and experience. My doctoral research primarily concentrated on applying principles from chemical and physical sciences to deepen our understanding of the complexities of the human brain. Additionally, I developed innovative tools that not only found utility in neuroscience but also in immunology and various other branches of the life sciences.

Throughout my career, I advanced the life science field by pioneering single-molecule spectroscopy techniques to probe the structural characteristics of membrane receptors within the brain. This work involved utilizing brain nanovesicles and Total Internal Reflection Fluorescence (TIRF) microscopy methods to investigate the stoichiometry of nicotinic receptors. Additionally, I developed genetic probes based on GCaMP to characterize astrocyte calcium activity in both in vitro and in vivo settings. These GCaMP-based probes played a pivotal role in enabling researchers to unravel the subcellular calcium dynamics within astrocyte populations in the brain.

Besides this, I have also contributed to the fundamental understanding of nanovesicle and exosome/extracellular vesicle biology, employing cutting-edge analytical methodologies. 

I am a strong advocate of research collaborations and enjoy working with researchers in different areas of physical, biological and computational sciences.  Please feel free to reach out to me at aryalpsurya@gmail.com.