Surya P Aryal, PhD

I am a Research Scientist leading R&D efforts in the biotechnology and biopharma industries. With expertise spanning multiple STEM disciplines, I also provide consulting, training, and evaluation services to leading artificial intelligence and large language model developers, with a focus on chemistry, biology, and biotechnology. Alongside my industrial and AI-focused research, I have a strong passion for teaching and have contributed to higher education and academic research.

  My areas of expertise include biomarker discovery, extracellular vesicles, assay development, optical microscopy, analytical chemistry, single-molecule biophysics, and molecular neurobiology. I hold a B.Sc. in Chemistry (with minors in Mathematics and Physics) and an M.Sc. in Chemistry (with a minor in Biochemistry) from Tribhuvan University, as well as a Ph.D. in Analytical and Biophysical Chemistry from the University of Kentucky.

  Currently, my work focuses on delivering innovative solutions to the life sciences, biotechnology, and AI industries by leveraging my interdisciplinary background. My doctoral research applied chemical and physical principles to gain deeper insight into the complexities of the human brain. During this work, I developed innovative experimental tools that advanced molecular neuroscience and demonstrated broader applicability to immunology and other life sciences fields.

 I pioneered single-molecule spectroscopy approaches to examine membrane receptor structure and organization in the brain, utilizing brain-derived nanovesicles and Total Internal Reflection Fluorescence (TIRF) microscopy to study nicotinic receptor stoichiometry. In addition, I developed GCaMP-based genetic probes to characterize astrocyte calcium signaling in both in vitro and in vivo systems, enabling the investigation of subcellular calcium dynamics with high spatial and temporal resolution. I have also contributed to the training and evaluation of machine learning models for applications in image processing and single-molecule data analysis.

  Furthermore, I have advanced the understanding of nanovesicle and extracellular vesicle (exosome) biology through the application of cutting-edge analytical chemistry techniques and bioassay development.

 A strong advocate for collaborative research, I thrive in multidisciplinary environments that integrate physical, biological, and computational sciences. Please feel free to reach out to connect or explore potential collaborations at aryalpsurya@gmail.com.

Disclaimer: The views expressed here, and on any public platform, are my own and do not represent those of any current or former employers, clients, or collaborators.