Surya P Aryal, PhD

I am a Research Scientist leading R&D efforts in the biotechnology and biopharma industries. With expertise across various STEM fields, I also provide consulting, training, and evaluation services to leading artificial intelligence and large language model developers, specializing in chemistry, biology, and biotechnology. Alongside my industrial and AI research, I have a strong passion for teaching and have contributed to higher education and academic research.

My areas of focus include biomarker discovery, extracellular vesicles, assay development, optical microscopy, analytical chemistry, single-molecule biophysics, and molecular neurobiology. I hold a B.Sc. in Chemistry (with minors in Mathematics and Physics) and an M.Sc. in Chemistry (with a minor in Biochemistry) from Tribhuvan University, as well as a Ph.D. in Analytical and Biophysical Chemistry from the University of Kentucky.

 Currently,  my work aims to provide innovative solutions to the life sciences, biotechnology, and AI industries by leveraging my interdisciplinary expertise. My doctoral research applied chemical and physical principles to gain a deeper insight into the complexities of the human brain. I also developed innovative tools that advanced molecular neuroscience and had applications in immunology and other life sciences fields.

 I have pioneered single-molecule spectroscopy techniques to examine membrane receptor structures in the brain, using brain nanovesicles and Total Internal Reflection Fluorescence (TIRF) microscopy to study nicotinic receptor stoichiometry. Additionally, I developed GCaMP-based genetic probes to characterize astrocyte calcium activity in both in vitro and in vivo settings, which have been critical for exploring subcellular calcium dynamics in astrocytes. I was also involved in the training and evaluation of machine learning models with applications in image processing and single-molecule data analysis. 

Furthermore, I have advanced the understanding of nanovesicle and exosome/extracellular vesicle biology using cutting-edge analytical and bioassay methods. I was also involved in coll

A strong advocate for research collaboration, I thrive in multidisciplinary teams across physical, biological, and computational sciences. Please feel free to reach out to me at aryalpsurya@gmail.com.