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MICRONEEDLES FOR DRUG DELIVERY & TISSUE REPAIR
Electroconductive Microneedle Patch
An wearable MN patch for the directional delivery of potent therapeutic agents to deep cutaneous tissue for antimicrobial therapy. The conductive MNs fabricated using carbon nano-tube (CNT) and Gelatin Methacrylate (GelMA) can allow directional transportation of small molecules into the deep tissue facilitated by electric stimulation.
Biomaterials 314 (2025): 122908.
Dual-Responsive Dissolvable Microneedles
A dissolvable microneedle dressing loaded with novel copper complex containing an Azo-Schiff base (Cu-Azo@DMN). This system demonstrates oxidative stress-mediated antimicrobial activity and enables pH-responsive Cu2+ release in the acidic polymicrobial infection microenvironment. Furthermore, Cu-Azo@DMN also exhibits enhanced antimicrobial efficacy through photo-responsive Cu2+ release. Following pathogen clearance, the system autonomously tunes down Cu2+ release to resolve inflammation and promote angiogenesis, thereby facilitating tissue regeneration.
Materials Today Bio (2025): 102219.
PIEZOELECTRIC BIOMATERIALS FOR TISSUE REGENERATION
Bioactive Electrospun Nanofibrous Bandage for Wound Healing
A Piezoelectric, bioactive Cellulose Acetate (CA) electrospun nanofibrous mat incorporated zinc oxide (ZnO). The incorporation of ZnO into the cellulose acetate nanofibers exhibits a superior mechanical, porous, piezoelectrical, thermally stable, biocompatible, nanofibrous which can modulate the wound microenvironment, enhances the cell adhesion and faster cells migration which are essential for the wound healing.
Frontiers in Immunology 14 (2023): 1245343.
Osteoconductive Nanofibrous Coatings for Orthopedic Implants
An electrospun nanofibrous coating for Ti-implants using piezoelectric Polyvinylidene fluoride (PVDF) polymer reinforced with osteoconductive nanofiller Zinc oxide (ZnO). We have found that by varying the ZnO content in the PVDF matrix, we can modulate the mechanical, thermal, physicochemical stability, and piezoelectric characteristics of the electrospun coating. Using the biomimetic mechanical bioreactor, we have investigated the piezoelectricity-mediated increased focal adhesion and enhanced F-actin production under the physiologically relevant (i.e., 1%) mechanical strain in bone cells.
Journal of Biomedical Materials Research Part A, 113(8), 2025 e37971.
NEXT-GENERATION WOUND CLOSURE DEVICES
Bioinspired, Bioabsorable Surgical Staple for Faster Efficient Wound Closure
Manti's foreleg-inspired biodegradable polymer-based surgical staples, which can elicit suitable mechanical strength, and metal-like ductility, with excellent biocompatibility and also can prevent secondary surgical infections for efficient wound closing. The economical, biodegradable surgical staple composed of CA + PLLA FRP-based polymer composite to meet benchmarks of an ideal wound closure system with other clinical needs like prevention of secondary infection, radiography compatibility, etc.
International Journal of Biological Macromolecules 248 (2023): 126477.
SMART BIOMATERIALS
pH and Light-responsive antimicrobials
Dual-responsive Cu(II) complex containing biphenyl-based Azo-Schiff base (Cu-Azo) was synthesized, which exhibited on-demand release of Cu2+ upon internal (pH) and external (light) stimulus. The presence of amide (-CONH-) and Schiff base (-C=N-) linkages enabled pH-responsive cleavage in the acidic infection environment, while the light-sensitive azo (-N=N-) moieties exhibited photo-degradation under external light stimulation. This dual responsiveness enabled precise control over Cu2+-release at different stages of infection healing.
Advances in Colloid and Interface Science (2025): 103607.
Materials Today Bio (2025): 102219.
Immunomodulatory Hydrogels for Osteoarthitis Treatment
An ECM mimetic, injectable hydrogel combining thermo-responsive polymers, i.e., Pluronic F-127 (PF-127) and Poloxamer 407 (P-407), and loaded with diclofenac sodium to modulate the chronic inflammatory conditions by inhibiting the expression of several pro-inflammatory genes for the treatment of RA.
BMC biotechnology 24.1 (2024): 26.
Magnetic Nanoparticles for Anticancer Therapy
Magnetic nanoparticles conjugated with carbon quantum dots (M-CQDs) for dual magnetic hyperthermia and photodynamic therapy for cancer. The dual acting M-CQDs was prepared by combining Fe-magnetic nanoparticles combined with amine-carbon quantum dots. The localized M-CQDs combined with MHT and PDT effects exhibit the highest anti-tumorigenicity.
Nanotheranostics 8.4 (2024): 442.
INTERVENING NEURO-IMMUNO CROSSTALKS
Direct Stimulation of Sensory Nerves via Electroconductive Microneedles
The application of electric-stimulated microneedles not only facilitated the delivery of therapeutic agent to deeper tissue level to eliminate C. albicans but also stimulated the subcutaneous neuro-immune axis to induce protective immunity against fungal infection mediated by dermal dendritic and γδ-T cells.
Biomaterials 314 (2025): 122908.
Suppression of Sensory Nerves modulates Pain and Infection Healing
Other Interests
Porous Silicon Microparticles
Biosensor
Biosensor
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