List of Publications

BRIC 한빛사 논문 (Highlighted papers)

Peer-reviewed articles (* Equal contribution) 

2024

• Park SS, Lee Y-K, Kim YH, Park SH, Kang HY, Kim JC, Kim DH, Lim SB, Yoon G, Kim J-H, Choi YW, Park TJ. Distribution and Impact of p16INK4A+ Senescent Cells in Elderly Tissues: A Focus on Senescent Immune Cell and Epithelial Dysfunction. submitted

• Hong J, Jin H, Choi M, Lim DWT, Park JE, Kim YS, Lim SB. Matrisomics: Beyond the Extracellular Matrix for Unveiling Tumor Microenvironment. submitted

• Prazanowska K, Kim T-H, Kang JW, Jin Y-H, Kwon S, Lim SB. A Single-Cell RNA-Seq Dataset of Peripheral Blood Cells in Long COVID Patients on Herbal Therapy. submitted

• Go Y*, Ng J*, Lim DWT, Lim SB. HepScope: CNN-based single-cell discrimination of malignant hepatocytes. submitted 

• Yoon JH, Kim HS, Yoon MG, Baek GO, Weon JH, Kim S, Kang M, Choi J, Jang S, Go Y, Ng J, Lim SB, Nam SW, Jeong JY, Cho HJ, Kim SS, Cheong JY, Eun JW. GULP1 Acts as a Predominant Mediator of Metastasis and an Independent Predictor of Recurrence in Hepatocellular Carcinoma. submitted

• Junaid M, Bae Y, Choe HK,  Kondoh K, Lee EJ*, Lim SB*. Deciphering molecular inputs to CRH-PVN neurons from POMC-ARC neurons. in revision

• Ahn HR, Kim S, Baek GO, Yoon MG, Kang M, Ng J, Go Y, Lim SB, Han JE, Kim SS, Cheong JY, Eun JW, Cho HJ. Sortilin1 promotes angiogenesis and systemic metastasis in hepatocellular carcinoma by activating the Notch signaling pathway and increasing CD133 expression. in revision

• Lim SB and Cho HJ. Correspondence on Editorial regarding “Unveiling etiology-specific blood biomarkers in hepatocellular carcinoma: a gateway to personalized medicine”. Clinical and Molecular Hepatology, accepted (invited)

• Junaid M, Lee EJ*, Lim SB*. Single-cell and spatial omics: exploring hypothalamic heterogeneity, Neural Regeneration Research, accepted, 2024 (invited)

• Hong JW*, Eun JW,* Baek GO, Park S, Cho HJ*, Lim SB*. Multi-omics Profiling of Buffy Coat and Plasma Unveils Etiology-specific Signatures in Hepatocellular Carcinoma. Clinical and Molecular Hepatology, accepted, 2024

• Park SS, Lee Y-K, Choi YW, Lim SB, Park SH, Kim HK, Shin JS, Kim YH, Kim J-H, Park TJ. Cellular Senescence is Associated with the Spatial Evolution Towards a Higher Metastatic Phenotype in Colorectal Cancer. Cell Reports 43(3), 113912, 2024

• Hong SM, Lee A-Y, Ha Y-J, Ng JT, Yoon G, Lim SB, Morgan MJ, Cha J-H, Lee D, Kim Y-S. NAMPT-driven M2 polarization of tumor-associated macrophages leads to an immunosuppressive microenvironment in colorectal cancer. Advanced Science, 2303177, 2024. 

• Kim C-L, Lim S-B, Choi S-H, Kim DH, Sim YE, Kim K, Jo E-H, Lee K, Park H-S, Lim SB, Kang L-J, Lee Y, Jung H-S, Hansen C, Mo J-S. The LKB1/TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway. Cell Death & Disease, 15, 76, 2024 

2023

• Hong J, Min S, Yoon G*, Lim SB*. SRSF7 downregulation induces cellular senescence through generation of MDM2 variants. Aging (15), 24, 2023.  

• Lim SB*, Choi J-I*, Go Y, Ha Y-J, Yang MJ, Park S-H, Kim S, Kim Y-S*, Lee D*. Macrophage-derived TNF-enriched tumor microenvironment shapes pancreatic ductal adenocarcinoma into the basal-like molecular phenotype through upregulating TAp63. Clinical and Translational Medicine (13), 12, 2023 *한빛사논문

• Junaid M, Choe HK,  Kondoh K, Lee EJ*, Lim SB*. Unveiling Hypothalamic Molecular Signatures via Retrograde Viral Tracing and Single-Cell Transcriptomics. Scientific Data, 10, 861, 2023 *한빛사논문

• YH Kim, YK Lee, SS Park, SH Park, SY Eom, YS Lee, WJ Lee, J Jang, D Seo, HY Kang, JC Kim, SB Lim, G Yoon, HS Kim, JH Kim, TJ Park. Mid-Old Cells are Potential Target for Anti-aging Interventions in the Elderly. Nature Communications, 14, 7619, 2023.

• K Prazanowska, J Hong, SB Lim. Single-cell insights into the dynamic tumor microenvironment changes during immunotherapy of non-small cell lung cancer. Translational Lung Cancer Research 12(8):1816-1821, 2023. 

• O’Connor LM, O’Connor BA, Lim SB, Zeng J, Lo CH. Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective. Journal of Pharmaceutical Analysis 13(8):836-850, 2023. 

• K Jiang, SB Lim, JW Xiao, DS Jokhun, ML Shang, X Song, P Zhang, LF Liang, BC Low, GV Shivashankar, CT Lim. Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance. Advanced Science 10(22), 2201663, 2023.

• K Prazanowska and SB Lim. An integrated single-cell transcriptomic dataset for non-small cell lung cancer. Scientific Data 10, 167, 2023 *한빛사논문

• JW Eun, JH Yoon, HR Ahn, S Kim, YB Kim, SB Lim, W Park, TW Kang, GO Baek, MG Yoon, JA Son, JH Weon, SS Kim, HJ Cho, JY Cheong. Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib. Cancer Communications, 43 (4), p.455-479, 2023.

• SS Park, Y-K Lee, SH Park, SB Lim, YW Choi, JS Shin, YH Kim, J-H Kim, TJ Park. p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer. Heliyon e13170, 2023. 

2022 

• AHP Loh, C Angelina, MK Wong, SH Tan, SA Sukhatme, T Yeo, SB Lim, YT Lee, SY Soh, W Leung, KTE Chang, YW Chua, SMF Alkaff, TKH Lim, CT Lim, ZX Chen. Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse. Frontiers in Oncology, 2022 

• S Min, SM Kwon, J Hong, YK Lee, TJ Park, SB Lim*, G Yoon*. Mitoribosomal deregulation drives senescence via TPP1-mediated telomere deprotection. Cells 2022, 11, 2079. 

• M Junaid*, A Lee*, J Kim, TJ Park, SB Lim. Transcriptional heterogeneity of cellular senescence in cancer. Molecules and Cells, 2022 

• C Sun, S Kannan, IY Choi, HT Lim, Hao Zhang, GS Chen, N Zhang, SH Park, C Serra, SR Iyer, TE Lloyd, C Kwon, RM Lovering, SB Lim, P Andersen, KR Wagner, G Lee. Human pluripotent stem cell-derived myogenic progenitor cells engraft to become quiescent functional satellite cells in vivo. Cell Stem Cell , Vol. 29 Issue 4 Pages 610-619, 2022 

• KY Goh, KW Lau, TYD Cheng, SC Tham, CT Lim, NG Iyer, SB Lim*, DWT Lim*. Matrisomal genes in squamous cell carcinoma of head and neck influence tumor cell motility and response to cetuximab treatment. Cancer Communications 42 (4), p.355-359, 2022 http://doi.org/10.1002/cac2.12279 *한빛사논문

2021 

• Lee HJ, Lee JJ, Park NY, Dubey SK, Kim TY, Ruan K, Lim SB, Park SH, Ha SW, Kovlyagina I, Kim YT, Kim SJ, Oh YH, Kim HS, Kang SU, Song MR, Lloyd TE, Maragakis NJ, Hong YB, Eoh HJ, Lee G, Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nature Neuroscience 24, pages1673–1685, 2021 

• Y Bellotti, SB Lim, NG Iyer, WT Lim, CT Lim. Prognostic matrisomal gene panel and its association with immune cell infiltration in head and neck carcinomas. Cancers, 13 (22), 5761, 2021.

• J Kim*, SY Kim*, SX Ma, SM Kim*, SJ Shin, YS Lee, HJ Chang, HS Chang, CS Park, SB Lim*, PPARγ targets-derived diagnostic and prognostic index for papillary thyroid cancer, Cancers, 13 (20), 5110, 2021  

• Z Pan*, SB Lim*, J Kuan, CT Weng, LB Chuan, CT Lim.  Distinct mRNAs in cancer extracellular vesicles activate angiogenesis and alter transcriptome of vascular endothelial cells, Cancers 13 (9):2009, 2021 

• SX Ma and SB Lim. Single-cell RNA sequencing in Parkinson's disease, Biomedicines 9 (4), 368, 2021 

• Y Gao, D Nguyen, T Yeo, SB Lim, WX Tan, L Jin, JYK Long, FAB Aloweni, YJA Liew, SY Ang, SD/O Maniya, I abdelwahab, KP Loh, CH Chen, D Leavesley, SYJ Ho, CT Lim. A flexible multiplexed immunosensor for point-of-care in situ wound monitoring, Science Advances 7 (21), eabg9614, 2021

• M Shang, SB Lim, J Kuan, YS Yap, BL Khoo, J Han, CT Lim.  Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells, Lab on a Chip 21, 746-754, 2021

2017-2020 (Publications during PhD and Postdoc)

• SB Lim, VL Dawson, TM Dawson, SU Kang.  ACE2-expressing endothelial cells in aging mouse brain, Journal of Brain Research 3 (3), 1-5, 2020

• SB Lim, NV Menon, CT Lim. Microfluidic tools for probing micro‐culprits: Opportunities and challenges in microfluidic diagnostics, EMBO Reports 21 (2), e49749, 2020

• SB Lim, SJ Tan, WT Lim, CT Lim. Compendiums of cancer transcriptomes for machine learning applications, Scientific Data 6, 194, 2019 

• SB Lim, W Di Lee, J Vasudevan, WT Lim, CT Lim. Liquid biopsy: one cell at a time, npj Precision Oncology 3, 23, 2019 *Featured in Nature’s Leading Cancer Research collection, 2020

• SB Lim, CT Lim, DWT Lim. Matrisomal abnormality: a predictive biomarker for cancer immunotherapy, Annals of Oncology 30 (Supplement_6), mdz338. 057, 2019

• NV Menon, SB Lim, CT Lim. Microfluidics for personalized drug screening of cancer, Current Opinion in Pharmacology 48, 155-161, 2019

• SB Lim, CT Lim, WT Lim. Single-cell analysis of circulating tumor cells: why heterogeneity matters, Cancers 11 (10), 1595, 2019

• SB Lim, T Yeo, W Di Lee, AAS Bhagat, SJ Tan, DSW Tan, WT Lim, CT Lim. Addressing cellular heterogeneity in tumor and circulation for refined prognostication, Proceedings of the National Academy of Sciences 116 (36), 17957-17962, 2019  *한빛사논문

• SB Lim, MLK Chua, JPS Yeong, SJ Tan, WT Lim, CT Lim. Pan-cancer analysis connects tumor matrisome to immune response, npj Precision Oncology 3, 15, 2019 *Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Members,  *한빛사논문

• BL Khoo, G Grenci, JSY Lim, YP Lim, J Fong, WH Yeap, SB Lim, SL Chua, SC Wong, YS Yap, SC Lee, CT Lim, J Han. Low-dose anti-inflammatory combinatorial therapy reduced cancer stem cell formation in patient-derived preclinical models for tumour relapse prevention, British Journal of Cancer 120 (4), 407, 2019

• SB Lim, SJ Tan, WT Lim, CT Lim. A merged lung cancer transcriptome dataset for clinical predictive modeling, Scientific Data 5, 180136, 2018

• SB Lim, SJ Tan, LIM Wan-Teck, CT Lim. An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer, Nature Communications 8 (1), 1-11, 2017 *한빛사논문

• KR Mun, SB Lim, Z Guo, H Yu. Biomechanical effects of body weight support with a novel robotic walker for over-ground gait rehabilitation, Medical & Biological Engineering & Computing 55 (2), 315-326, 2017