SYSTEMS APPROACHES TO STUDY CANCER METASTASIS AND GENE REGULATION

ABOUT US

Welcome to the Dasgupta Lab Homepage. Our lab is based in the Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, Buffalo, NY, a National Cancer Institute (NCI) designated comprehensive cancer center. We also have adjunct affiliation with Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, and located in the heart of Buffalo Niagara Medical Campus (BNMC). Our laboratory focusses on defining the underlying mechanisms that promote tumor progression and metastasis. We take a systems biology approach investigating metabolic pathways, genetic and epigenetic regulation, and immune evasion mechanisms that selectively sustain the growth and progression of metastatic tumors. State of art facilities such as proteomics, genomics, and metabolomics along with molecular biology techniques are widely used in multiple model systems of Genetically Engineered Mouse Models (GEMMs), Patient-Derived Xenograft (PDX), and syngeneic tumor models.

RESEARCH DIRECTIONS

DISCOVERING METABOLIC DYSREGULATION IN CANCER

DEFINING TRANSCRIPTIONAL AND EPIGENETIC REGULATION

DECODING TUMOR MICROENVIRONMENT AND IMMUNE RESPONSE 

SELECTED PUBLICATIONS

RECENT LAB NEWS

PUBLICATION                       December 2022

BUFFALO, N.Y. — Metastasis, or the spread of cancer cells from a primary tumor to distant organs, lacks effective treatment options and remains a major cause of cancer-related deaths. To better understand....

RESEARCH                           January 2021

While prostate cancer originates within the prostate, metastasis, or the spread of a tumor from the site of origin to other organs, remains a leading cause of death ....