Publications

Portillo JC, Yu JS, Vos S, Bapputty R, Lopez Corcino Y, Hubal A, Daw J, Arora S, Sun W, Lu ZR, Subauste CS. Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells. Diabetologia. 2022 Dec;65(12):2157-2171. doi: 10.1007/s00125-022-05775-6. Epub 2022 Aug 3. PMID: 35920844; PMCID: PMC9630214.

Yu JS, Daw J, Portillo JC, Subauste CS. CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X7 in the Diabetic Retina. Invest Ophthalmol Vis Sci. 2021 Sep 2;62(12):22. doi: 10.1167/iovs.62.12.22. PMID: 34546322; PMCID: PMC8458989.

Subauste CS. Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications. Front Cell Dev Biol. 2021 Jun 9;9:673813. doi:10.3389/fcell.2021.673813. PMID: 34179003; PMCID: PMC8220159.

Subauste CS. The CD40-ATP-P2X ₇ Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells. Front Immunol. 2019 Dec 17;10:2958. doi: 10.3389/fimmu.2019.02958. PMID: 31921199; PMCID: PMC6928124.

Portillo JC, Yu JS, Hansen S, Kern TS, Subauste MC, Subauste CS. A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion. FASEB J. 2021 Mar;35(3):e21412. doi: 10.1096/fj.201903203RR. PMID: 33675257; PMCID: PMC8101361.

Lopez Corcino Y, Gonzalez Ferrer S, Mantilla LE, Trikeriotis S, Yu JS, Kim S, Hansen S, Portillo JC, Subauste CS. Toxoplasma gondii induces prolonged host epidermal growth factor receptor signalling to prevent parasite elimination by autophagy: Perspectives for in vivo control of the parasite. Cell Microbiol. 2019 Oct;21(10):e13084. doi: 10.1111/cmi.13084. Epub 2019 Jul 17. PMID: 31290228; PMCID: PMC6771541.

Subauste CS. Interplay Between Toxoplasma gondii, Autophagy, and Autophagy Proteins. Front Cell Infect Microbiol. 2019 May 1;9:139. doi: 10.3389/fcimb.2019.00139. PMID: 31119109; PMCID: PMC6506789.

Portillo JC, Van Grol J, Saffo S, Lopez Corcino Y, Rodriguez M, Fox BA, Bzik DJ, Ward NL, Dubyak GR, Rojas RE, Toosi Z, Subauste CS. CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii. Infect Immun. 2019 Jul 23;87(8):e00868-18. doi: 10.1128/IAI.00868-18. PMID: 31109947; PMCID: PMC6652775.

Corcino YL, Portillo JC, Subauste CS. Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii. Sci Rep. 2019 Jan24;9(1):669. doi: 10.1038/s41598-018-36724-2. PMID: 30679495; PMCID: PMC6345933.

Portillo JC, Muniz-Feliciano L, Lopez Corcino Y, Lee SJ, Van Grol J, Parsons SJ, Schiemman WP, Subauste CS. Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy.PLoS Pathog. 2017 Oct 16;13(10):e1006671. doi: 10.1371/journal.ppat.1006671. PMID: 29036202; PMCID: PMC5658194.

Subauste CS. CD40, a Novel Inducer of Purinergic Signaling: Implications to the Pathogenesis of Experimental Diabetic Retinopathy. Vision (Basel). 2017 Aug 12;1(3):20. doi: 10.3390/vision1030020. PMID: 31740645; PMCID: PMC6835793.

Portillo JC, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern TS, Dubyak GR, Subauste CS. CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. Diabetes. 2017 Feb;66(2):483-493. doi: 10.2337/db16-0051. Epub 2016 Jul 29. PMID: 27474370; PMCID: PMC5248988.

Samuels IS, Portillo JC, Miao Y, Kern TS, Subauste CS. Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects. Vis Neurosci. 2017 Jan;34:E009.doi: 10.1017/S0952523817000074. PMID: 28965505; PMCID: PMC8893597.

Portillo JC, Lopez Corcino Y, Dubyak GR, Kern TS, Matsuyama S, Subauste CS. Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6278-6286. doi: 10.1167/iovs.16-20301. PMID: 27893093; PMCID: PMC5119488.

Liu E, Lopez Corcino Y, Portillo JA, Miao Y, Subauste CS. Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages. Infect Immun. 2016 Aug 19;84(9):2616-26. doi: 10.1128/IAI.00101-16. PMID: 27354443; PMCID: PMC4995900.

Greene JA, Portillo JA, Lopez Corcino Y, Subauste CS. CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells. PLoS One. 2015 Dec 28;10(12):e0144133. doi: 10.1371/journal.pone.0144133. PMID: 26710229; PMCID: PMC4692437.

Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27;290(48):29035-44. doi: 10.1074/jbc.M115.682310. Epub 2015 Oct 14. PMID: 26468292; PMCID: PMC4661415.

Liu E, Van Grol J, Subauste CS. Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells. Microbes Infect. 2015 Apr;17(4):275-84. doi: 10.1016/j.micinf.2014.12.008. Epub 2015 Jan 8. PMID: 25578385; PMCID: PMC4385469.

Portillo JA, Greene JA, Schwartz I, Subauste MC, Subauste CS. Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells. Immunology. 2015 Jan;144(1):21-33. doi: 10.1111/imm.12361. PMID: 25051892; PMCID: PMC4264907.

Portillo JA, Schwartz I, Zarini S, Bapputty R, Kern TS, Gubitosi-Klug RA,Murphy RC, Subauste MC, Subauste CS. Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling. Invest Ophthalmol Vis Sci. 2014 Dec 4;55(12):8590-7. doi: 10.1167/iovs.14-15340. PMID: 25477319; PMCID: PMC4280881.

Portillo JA, Greene JA, Okenka G, Miao Y, Sheibani N, Kern TS, Subauste CS. CD40 promotes the development of early diabetic retinopathy in mice. Diabetologia. 2014 Oct;57(10):2222-31. doi: 10.1007/s00125-014-3321-x. PMID: 25015056; PMCID: PMC4291184.

Cheng L, Bu H, Portillo JA, Li Y, Subauste CS, Huang SS, Kern TS, Lin F. Modulation of retinal Müller cells by complement receptor C5aR. Invest Ophthalmol Vis Sci. 2013 Dec 17;54(13):8191-8. doi: 10.1167/iovs.13-12428. PMID: 24265019; PMCID: PMC3867184.

Muniz-Feliciano L, Van Grol J, Portillo JA, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS. Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite. PLoS Pathog. 2013;9(12):e1003809. doi: 10.1371/journal.ppat.1003809. Epub 2013 Dec 19. PMID: 24367261; PMCID: PMC3868508.

Van Grol J, Muniz-Feliciano L, Portillo JA, Bonilha VL, Subauste CS. CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins. Infect Immun. 2013 Jun;81(6):2002-11. doi: 10.1128/IAI.01145-12. Epub 2013 Mar 18. PMID: 23509150; PMCID: PMC3676008.

Ogolla PS, Portillo JA, White CL, Patel K, Lamb B, Sen GC, Subauste CS. The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen. PLoS Pathog. 2013;9(8):e1003557. doi: 10.1371/journal.ppat.1003557. Epub 2013 Aug 22. PMID: 23990781; PMCID: PMC3749959.

Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A. Autophagy protects the retina from light-induced degeneration. J Biol Chem. 2013 Mar 15;288(11):7506-7518. doi: 10.1074/jbc.M112.439935. Epub 2013 Jan 22. PMID: 23341467; PMCID: PMC3597791.

Subauste C. Animal models for Toxoplasma gondii infection. Curr ProtocImmunol. 2012 Feb;Chapter 19:19.3.1-19.3.23. doi: 10.1002/0471142735.im1903s96. PMID: 22314833.

Portillo JA, Feliciano LM, Okenka G, Heinzel F, Subauste MC, Subauste CS. CD40 and tumour necrosis factor-α co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology. 2012 Feb;135(2):140-50. doi: 10.1111/j.1365-2567.2011.03519.x. PMID: 22044243; PMCID: PMC3277716.

Subauste CS, Ajzenberg D, Kijlstra A. Review of the series "Disease of the year 2011: toxoplasmosis" pathophysiology of toxoplasmosis. Ocul Immunol Inflamm. 2011 Oct;19(5):297-306. doi: 10.3109/09273948.2010.605198. PMID: 21970661.

Mehlotra RK, Cheruvu VK, Blood Zikursh MJ, Benish RL, Lederman MM, Salata RA, Gripshover B, McComsey GA, Lisgaris MV, Fulton S, Subauste CS, Jurevic RJ, Guillemette C, Zimmerman PA, Rodriguez B. Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race- specific influence on virologic success. J Infect Dis. 2011 Jul 15;204(2):291-8. doi: 10.1093/infdis/jir262. PMID: 21673041; PMCID: PMC3114473.

Tu Z, Portillo JA, Howell S, Bu H, Subauste CS, Al-Ubaidi MR, Pearlman E, Lin F. Photoreceptor cells constitutively express functional TLR4. J Neuroimmunol. 2011 Jan;230(1-2):183-7. doi: 10.1016/j.jneuroim.2010.07.022. PMID: 20801528; PMCID: PMC3019248.

Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS. The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One. 2010 Dec 31;5(12):e14472. doi: 10.1371/journal.pone.0014472. PMID: 21217818; PMCID: PMC3013095.

Van Grol J, Subauste C, Andrade RM, Fujinaga K, Nelson J, Subauste CS. HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS One. 2010 Jul 22;5(7):e11733. doi: 10.1371/journal.pone.0011733. PMID: 20661303; PMCID: PMC2908694.

Subauste CS. Autophagy as an antimicrobial strategy. Expert Rev Anti Infect Ther. 2009 Aug;7(6):743-52. doi: 10.1586/eri.09.41. PMID: 19681702; PMCID: PMC3280690.

Portillo JA, Okenka G, Kern TS, Subauste CS. Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry. Mol Vis. 2009 Jul 17;15:1383-9. PMID: 19626134; PMCID: PMC2713733.

Subauste CS. CD40 and the immune response to parasitic infections. Semin Immunol. 2009 Oct;21(5):273-82. doi: 10.1016/j.smim.2009.06.003. Epub 2009 Jul 18. PMID: 19616968; PMCID: PMC2758065.

Subauste CS. Autophagy in immunity against Toxoplasma gondii. Curr Top Microbiol Immunol. 2009;335:251-65. doi: 10.1007/978-3-642-00302-8_12. PMID: 19802569.Subauste CS. CD40, autophagy and Toxoplasma gondii. Mem Inst Oswaldo Cruz. 2009 Mar;104(2):267-72. doi: 10.1590/s0074-02762009000200020. PMID: 19430652.

Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carlson EC, Kern TS, Subauste CS. CD40 mediates retinal inflammation and neurovascular degeneration. J Immunol. 2008 Dec 15;181(12):8719-26. doi: 10.4049/jimmunol.181.12.8719. PMID: 19050292.

Subauste CS, Andrade RM, Wessendarp M. CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages. Autophagy. 2007 May-Jun;3(3):245-8. doi: 10.4161/auto.3717. Epub 2007 May 15. PMID: 17224624.

Subauste CS, Subauste A, Wessendarp M. Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients. J Immunol. 2007 Feb 1;178(3):1645-53. doi:10.4049/jimmunol.178.3.1645. PMID: 17237414.

Subauste CS. Primary immunodeficiencies and susceptibility to parasitic infections. Parasite Immunol. 2006 Nov;28(11):567-75. doi:10.1111/j.1365-3024.2006.00890.x. PMID: 17042928.

Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest. 2006 Sep;116(9):2366-77. doi: 10.1172/JCI28796. PMID: 16955139; PMCID: PMC1555650.

Subauste CS, Wessendarp M. CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon. Infect Immun. 2006 Mar;74(3):1573-9. doi: 10.1128/IAI.74.3.1573-1579.2006. PMID: 16495528; PMCID: PMC1418638.

Andrade RM, Portillo JA, Wessendarp M, Subauste CS. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005 May;73(5):3115-23. doi: 10.1128/IAI.73.5.3115-3123.2005. PMID: 15845519; PMCID:PMC1087328.

Andrade RM, Wessendarp M, Portillo JA, Yang JQ, Gomez FJ, Durbin JE, BishopGA, Subauste CS. TNF receptor-associated factor 6-dependent CD40 signalingprimes macrophages to acquire antimicrobial activity in response to TNF-alpha. JImmunol. 2005 Nov 1;175(9):6014-21. doi: 10.4049/jimmunol.175.9.6014. PMID:16237096.

Subauste CS, Wessendarp M, Portilllo JA, Andrade RM, Hinds LM, Gomez FJ, Smulian AG, Grubbs PA, Haglund LA. Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients. J Infect Dis. 2004 Jan 1;189(1):61-70. doi: 10.1086/380510. Epub 2003 Dec 23. PMID: 14702154.

Andrade RM, Wessendarp M, Subauste CS. CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism. J Immunol. 2003 Dec 15;171(12):6750-6. doi: 10.4049/jimmunol.171.12.6750. PMID: 14662879.

Subauste CS. CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection. J Infect Dis. 2002 Feb 15;185 Suppl1:S83-9. doi: 10.1086/338003. PMID: 11865444.

Subauste CS, Wessendarp M, Smulian AG, Frame PT. Role of CD40 ligand signaling in defective type 1 cytokine response in human immunodeficiency virus infection. J Infect Dis. 2001 Jun 15;183(12):1722-31. doi: 10.1086/320734. Epub 2001 May 17. PMID: 11372024.

Subauste C, Remington J. Animal models for Toxoplasma gondii infection. Curr Protoc Immunol. 2001 May;Chapter 19:Unit 19.3. doi: 10.1002/0471142735.im1903s28. PMID: 18432754.

Subauste CS, Wessendarp M. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that  controls IL-12-dependent and -independent T cell production of IFN-gamma. J Immunol. 2000 Aug 1;165(3):1498-505. doi: 10.4049/jimmunol.165.3.1498. PMID: 10903756.

Subauste CS, Wessendarp M, Sorensen RU, Leiva LE. CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer. J Immunol. 1999 Jun 1;162(11):6690-700. PMID: 10352287.

Subauste CS, Fuh F, de Waal Malefyt R, Remington JS. Alpha beta T cell response to Toxoplasma gondii in previously unexposed individuals. J Immunol. 1998 Apr 1;160(7):3403-11. PMID: 9531300.

Subauste CS, de Waal Malefyt R, Fuh F. Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen. J Immunol. 1998 Feb 15;160(4):1831-40. PMID: 9469444.

Hunter CA, Suzuki Y, Subauste CS, Remington JS. Cells and cytokines in resistance to Toxoplasma gondii. Curr Top Microbiol Immunol. 1996;219:113-25. doi: 10.1007/978-3-642-51014-4_11. PMID: 8791694.

Montoya JG, Lowe KE, Clayberger C, Moody D, Do D, Remington JS, Talib S, Subauste CS. Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells. Infect Immun. 1996 Jan;64(1):176-81. doi: 10.1128/iai.64.1.176-181.1996. PMID: 8557337; PMCID: PMC173743.

Subauste CS, Chung JY, Do D, Koniaris AH, Hunter CA, Montoya JG, Porcelli S, Remington JS. Preferential activation and expansion of human peripheral blood gamma delta T cells in response to Toxoplasma gondii in vitro and their cytokine production and cytotoxic activity against T. gondii-infected cells. J Clin Invest. 1995 Jul;96(1):610-9. doi: 10.1172/JCI118076. PMID: 7615835; PMCID:PMC185236.

Hunter CA, Candolfi E, Subauste C, Van Cleave V, Remington JS. Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunology. 1995 Jan;84(1):16-20. PMID: 7890300; PMCID: PMC1415199.

Beaman MH, Subauste CS, Wong SY, Remington JS. Toxoplasma-macrophage interactions. Immunol Ser. 1994;60:475-93. PMID: 8251588.

Hunter CA, Subauste CS, Van Cleave VH, Remington JS. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect Immun. 1994 Jul;62(7):2818-24. doi: 10.1128/iai.62.7.2818-2824.1994. PMID: 7911785; PMCID: PMC302887.

Hunter CA, Subauste CS, Remington JS. The role of cytokines in toxoplasmosis. Biotherapy. 1994;7(3-4):237-47. doi: 10.1007/BF01878489. PMID: 7865354.

Subauste CS, Remington JS. Immunity to Toxoplasma gondii. Curr Opin Immunol. 1993 Aug;5(4):532-7. doi: 10.1016/0952-7915(93)90034-p. PMID: 8216929.

Subauste CS, Dawson L, Remington JS. Human lymphokine-activated killer cells are cytotoxic against cells infected with Toxoplasma gondii. J Exp Med. 1992 Dec 1;176(6):1511-9. doi: 10.1084/jem.176.6.1511. PMID: 1460415; PMCID: PMC2119447.

Subauste CS, Koniaris AH, Remington JS. Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells. J Immunol. 1991 Dec 1;147(11):3955-9. PMID: 1940378.

Subauste CS, Remington JS. Role of gamma interferon in Toxoplasma gondii infection. Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):58-67. doi:10.1007/BF01964408. PMID: 1907542.

Subauste CS, Mikell FL, Kulkarni PS, Parcon JP. Tocainide-induced pulmonary toxicity. IMJ Ill Med J. 1988 Nov;174(5):287-9. PMID: 2906924.