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Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences, costing $224 billion annually. Altered metabolic status and subsequent changes in neuroendocrine signaling have recently been recognized for their ability to regulate the intake and reinforcing properties of alcohol. Importantly, problematic alcohol consumption induces malnutrition, and therefore, dysregulation in the neuroendocrine signaling as a result of compromised nutritional status may contribute to escalated alcohol intake and various behavioral impairments observed in alcoholics. However, nutrition and diet are often overlooked as an important treatment component in alcohol dependence. Therefore, one of the current projects aims to determine how access to a nutritionally complete palatable diet impacts alcohol intake in non-dependent conditions and if a similar approach would attenuate negative emotional state and escalated alcohol consumption in alcohol-dependent state. An integrative behavioral, pharmacological, biochemical, and molecular approach is employed throughout.
Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences, costing $224 billion annually. Altered metabolic status and subsequent changes in neuroendocrine signaling have recently been recognized for their ability to regulate the intake and reinforcing properties of alcohol. Importantly, problematic alcohol consumption induces malnutrition, and therefore, dysregulation in the neuroendocrine signaling as a result of compromised nutritional status may contribute to escalated alcohol intake and various behavioral impairments observed in alcoholics. However, nutrition and diet are often overlooked as an important treatment component in alcohol dependence. Therefore, one of the current projects aims to determine how access to a nutritionally complete palatable diet impacts alcohol intake in non-dependent conditions and if a similar approach would attenuate negative emotional state and escalated alcohol consumption in alcohol-dependent state. An integrative behavioral, pharmacological, biochemical, and molecular approach is employed throughout.
We are currently funded by National Institutes of Health (NIH) - National Institute of General Medical Sciences (NIGMS- 5SC3GM127173-02).
We are currently funded by National Institutes of Health (NIH) - National Institute of General Medical Sciences (NIGMS- 5SC3GM127173-02).
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