Srinivas Bathini, Ph.D.

Srinivas Bathini is currently working as a MEMS Product Engineer/Scientist at Teledyne Technologies Incorporated, Bromont, Canada. He obtained his Ph.D. from the Department of Mechanical Engineering at Concordia University, Montreal, Canada in 2021. His Ph.D. research focuses on the design, fabrication, and testing of various microfluidic/lab-on-a-chip devices for the capture, detection, and isolation of extracellular vesicles for the early diagnosis of cancer. Prior to his Ph.D., he worked in the Indian Space Research Organization (ISRO), Bangalore, India as an Intern and then MEMS Engineer on the design, fabrication of MEMS Gyroscope and MEMS Seismometer. His current research interests include micro-fabrication, LOC/microfluidics, biosensing, synthesis of gold nanoparticles, early diagnosis of cancer, and liquid biopsy.

Professional Experience:

• January 2021 - Present MEMS Product Engineer/Scientist, Teledyne Technologies Incorporated, Bromont, Canada

• January 2016 - April 2020 Teaching Assistant, Concordia University, Montreal, Canada

• May 2015 - April 2021 Research Assistant, Concordia University, Montreal, Canada

• October 2013 - December 2014 MEMS Engineer, Laboratory for Electro-Optics Systems (LEOS-ISRO), Bangalore, India

• June 2012 - July 2013 Internship, Laboratory for Electro-Optics Systems (LEOS-ISRO), Bangalore, India

Education:

• Ph.D. (2021) Concordia University, Montreal, Canada

Thesis: Lab-on-Chips for Capture, Detection, and Isolation of Cancerous Extracellular Vesicles

• M.Tech (2013) National Institute of Technology Karnataka (NITK), Mangalore, India

Thesis: Design, Fabrication, and Calibration of MEMS Inertial sensors

• B.Tech (2010) Jawaharlal Nehru Technological University (JNTU), Hyderabad, India

Thesis: Character/Number recognition by Template matching using Correlation

Awards:

• Ph.D. Seminar Award from Dept. of Mechanical, Industrial, and Aerospace Engg. for the best presentation, Concordia University - April 2019

• Best Paper Award at International Conf. of Theoretical and Applied Nanoscience and Nanotechnology (TANN'18), Niagara Falls – June 2018

• Best Paper Award at 20th International Conf. on Mechanical Engineering (ICME), Montreal – May 2018

• Conference and Exposition Award from Concordia University - 2018

• Conference and Exposition Award from Concordia University - 2017

• Concordia International Tuition Award of Excellence (ENCS, Concordia University) – 2015

Publications:

PATENTS

1. S. Bathini, M. Packirisamy, “Methods for Detecting, Isolation and Quantifying an Analyte in a Sample Based on Colloidal Suspension of Plasmonic Metal Nanoparticles” (US provisional (63,084,960) filed in September 2020)

JOURNALS

1. S. Bathini, S. Pakkiriswami, R. J. Ouellette, A. Ghosh, M. Packirisamy, "Magnetic Particle-Based Liquid Biopsy Chip for Isolation of Extracellular Vesicles and Characterization by Gene Amplification", Biosensors and Bioelectronics, 2021, 113585

2. S. Bathini, D. Raju, S. Badilescu, M. Packirisamy, "Effect of Cross-linking and Thermal Budget on Plasmonic Sensing and Sub-Surface Segregation of In-Situ Synthesized Gold in Polymer-Nano Composite", J. Nanopart Res., 2021, 23, Article 21

3. S. Bathini, S. Pakkirisami, D. Raju, S. Badilescu, R. J. Ouellette, A. Ghosh, M. Packirisamy, “Microfluidic Isolation of Extracellular Vesicles and Validation through AFM and DNA Amplification”, Eur. J. Extr. Ves., 2020, Vol. 1, 3-10

4. S. Badilescu, D. Raju, S. Bathini, and M. Packirisamy, “Gold Nano-Island Platforms for Localized Surface Plasmon Resonance Sensing: A Short Review", Mol., 2020, 25(20), 4661

5. D. Raju, S. Bathini, S. Badilescu, R.J. Ouellette, A. Ghosh, M. Packirisamy, “Study of Detection and Capture of Exosomes by Using the Morphologies of Ex Situ and In Situ Nanostructures", J. Elec. Soc., 2019, 166 (9), B3001-B3006

6. S. Bathini, D. Raju, S. Badilescu, A. Kumar, R.J. Ouellette, A. Ghosh, M. Packirisamy, “Nano–Bio Interactions of Extracellular Vesicles with Gold Nanoislands for Early Cancer Diagnosis,” Research, vol. 2018, Article ID 3917986

7. S. Bathini, R Duraichelvan, S Badilescu, M Packirisamy, “Microfluidic Plasmonic Bio-Sensing of Exosomes by Using a Gold Nano-Island Platform”, Intl. J. of Biomed. Biol. Engg (WASET). 2018, Vol. 12, No. 5, 226 – 229

8. D. Raju, S. Bathini, S. Badilescu, R.J. Ouellette, A. Ghosh, M. Packirisamy, “LSPR Detection of Extracellular vesicles using a silver-PDMS nano-composite platform suitable for sensor networks”, Ent. Info. Sys., 2018, Vol. 14, 532-541

9. D. Raju, S. Bathini, S. Badilescu, R.J. Ouellette, A. Ghosh, M. Packirisamy, “Comparison of Ex-Situ and In-Situ Nano Plasmonic Platforms for Capture and Detection of Exosomes”, ECS Trans. 2018, Vol. 85, Issue 13, 1407-1414

10. D. Raju, S. Bathini, S. Badilescu, R.J. Ouellette, A. Ghosh, M. Packirisamy, “Exosomes Detection by a Label-free Localized Surface Plasmonic Resonance Method”, ECS Trans. 2016, Vol. 75, Issue 17, 11-17

CONFERENCES

1. S. Bathini, D. Raju, S. Badilescu, S. Pakkiriswami, A. Ghosh, R. J. Ouellette, M. Packirisamy, "Genetic Validation of Physical Modeling of Nano-Bio Interactions between Extracellular Vesicles and Different Morphologies of Gold Nano Particles", MRS-ISEV Conference on Extracellular Vesicles in Cancer, August 2019, Nashville, USA

2. D. Raju, S. Bathini, S. Badilescu, S. Pakkiriswami, A. Ghosh, R. J. Ouellette, M. Packirisamy, "Plasmonic biosensing of exosomes using a microfluidic device (lab-on-a-chip) and its validation using droplet digital PCR", MRS-ISEV Conference on Extracellular Vesicles in Cancer, August 2019, Nashville, USA

3. S. Bathini, D. Raju, S. Badilescu, R.J.Ouellette, A. Ghosh, M. Packirisamy, "Comparison of Extracellular vesicles detection by microfluidic plasmonics of gold nano-island and nanocomposite platforms", International Society for Extracellular Vesicles (ISEV), April 2019, Kyoto, Japan

4. S. Bathini; R Duraichelvan; S Badilescu; A Ghosh; M Packirisamy, “Gold nano-island platform for the microfluidic plasmonic detection of exosomes”, International Conference of Theoretical and Applied Nanoscience and Nanotechnology (TANN'18), June 2018, Niagara Falls, Canada

5. S. Bathini; R Duraichelvan; S Badilescu; M Packirisamy, “Microfluidic Plasmonic Bio-Sensing of Exosomes by Using a Gold Nano-Island Platform”, 20th International Conference on Mechanical Engineering (ICME), May 2018, Montreal, Canada

6. R. Duraichelvan, B. Srinivas, S. Badilescu, A. Ghosh, M Packirisamy, “Comparison of Ex-Situ and In-Situ Nano Plasmonic Platforms for Capture and Detection of Exosomes”, 233rd ECS Meeting, May 2018, Seattle, USA

7. D. Raju, S. Bathini, S. Badilescu, A. Ghosh, RJ. Ouellette, M. Packirisamy, “Gold Nanoparticle Ring and Hole Structures-Based Platforms for Capture and Label-free Detection of Exosomes”, International Society for Extracellular Vesicles (ISEV2018) Annual Meeting, May 2018, Barcelona, Spain

8. A. Ghosh, S. Bathini, D. Raju, S. Badilescu, A. Kumar, R. J. Ouellette, M. Packirisamy, “Capture and label-free detection of extracellular vesicles on gold-nano-island based microfluidic Lab-on-a-CHIP device using synthetic-peptide Vn96”, ISEV2018 Annual Meeting, May 2018, Barcelona, Spain

9. S. Bathini; R Duraichelvan; S Badilescu; M Packirisamy, “Plasmonic detection of Extracellular vesicles in a microfluidic environment using synthetic-peptide (Vn96) based affinity capture”, International Society for Extracellular Vesicles (ISEV2017), May 2017, Toronto, Canada

10. R Duraichelvan; S. Bathini; S Badilescu; M Packirisamy, “Label-free Detection of Extracellular Vesicles Using Plasmonic Platforms”, TEXPO 2016 Conference, October 2016, Montreal, Canada

11. R Duraichelvan; S. Bathini; S Badilescu; M Packirisamy, “Exosomes Detection by a Label-free Localized Surface Plasmonic Resonance Method”, ECS Conference, October 2016, Hawaii, USA

12. R Duraichelvan; S. Bathini; S Badilescu; M Packirisamy, “Label-free Detection of Extracellular Vesicles Using Nanocomposite Platform”, Keystone Symposia Conference, June 2016, Colorado, USA

13. J John, S. Bathini, “Design and Fabrication of Silicon microstructure for Seismometer”, International Conference on Smart Materials, Structures and Systems (ISSS), July 2014, Bangalore, India