modeling and Analysis

Many of my projects involved the development of modeling and analysis techniques for a variety of problems.

1. A non-dimensional, two-parameter mechanical model for nucleus morphology - The model could predict molecular mechanisms causing differences in nuclear mechanics by merely analyzing the changes in nuclear morphology.
2. Automated 3D image processing algorithm for measuring nuclear morphology from confocal stacks - Adapted an optimization technique to processes the entire confocal stack and obtain the boundary surface of the nucleus.
3. Automated analysis of AFM indentation curves - Developed an automated routine for fitting Hertzian contact model to AFM indentation curves to estimate the apparent modulus of elasticity of single cells and nuclei.
4. A computational model for replication and translation of Coxsackie Virus RNA - Simulated the kinetics of viral translation and replication by modeling the interaction of viral RNA with host-cell proteins.