Publications
43. De Silva P, Saad M, Swain J, Mai Z, Kidd M, Choe J, Camargo A, Sanjay A, Chandrasekhara V, Pogue B, Wang K, Spring BQ, Maytin E, Hasan T. "Photodynamic priming with red light triggers adaptive immune responses in a pancreatic cancer mouse model". (Submitted).
42. Zahid MU, Waguespack M, Harman RC, Kercher EM, Nath S, Hasan T, Rizvi I, Spring BQ, Enderling H. "Fractionated photoimmunotherapy to stimulate an anti-tumor immune response". (Submitted).
41. Zhang K, Ducourthial G, Sharan T, Mohan A, Hou J, Timilsina S, Liang R, Louradour F, Spring BQ. "Video-rate two-photon microendoscopy using second harmonic resonance fiber scanning". (Submitted).
40. Spring BQ, Palanisami A, Kercher EM, Saad MA, Lang RT, Sutin J, Mai Z, Hasan T. "Sparse-spectral microendoscopy for real-time visualization of tumor cell phenotype and microenvironment spatial heterogeneity in vivo". (Under review; bioRxiv preprint).
39. Spring BQ, Watanabe K, Ichikawa M, Mallidi S, Matsudaira T, Timerman D, Swain JWR, Mai Z, Wakimoto H, Hasan T. "Red light-activated depletion of drug-refractory glioblastoma stem cells and chemosensitization of an acquired-resistant mesenchymal phenotype" Photochemistry and Photobiology (2024) Download PDF
38. Wu X, Ishrak R, Reihanisaransari R, Verma Y, Spring BQ, Singh K, Reddy R. "High-speed forward-viewing OCT probe based on Lissajous sampling and sparse reconstruction". Optics Letters (2024) 49, 3652-3655 Download PDF
37.Timilsina S, Saad MA, Lang RT, Hasan T, Spring BQ. "Methods for assessing and removing non-specific photoimmunotherapy damage in patient-derived tumor cell culture models" Photochemistry and Photobiology (2024) Download PDF
36. Kercher EM, Tatz J, Palanisami A, Fang Q, Spring BQ. "Video-rate hyperspectral unmixing for multiplexed microscopy and microendoscopy". Sci Rep. (Accepted).
35. Lang RT, Saad MA, Palanisami A, Kercher EM, Price L, Spring BQ. "Micro-image mosaicking of video-rate multiplexed microendoscopy enables analysis of tumor heterogeneity". J Biomed Opt. (Accepted).
34. Sadiki A, Liu S, Vaidya SR, Kercher EM, Lang RT, McIsaac J, Spring BQ, Auclair JR, Zhou ZS. "Site-specific conjugation of native antibody: transglutaminase-mediated modification of conserved glutamine while maintaining the primary sequence and core Fc glycan via trimming with an endoglycosidase".Bioconjugate Chem. DOI: 10.1021/acs.bioconjchem.4c00013 Download PDF
33. Hasan T, Spring BQ, Palanisami A, inventors. The General Hospital Corporation (DBA Massachusetts General Hospital), assignee. "Methods of treating and imaging tumor micrometastases using photoactive immunoconjugates". United States patent US 11,547,300. 2023 Jan 10.
32. Price L, Tatz J, Sutin J, Spring BQ. "Multi-objective optimization of custom compound prism arrays for multiplexed optical imaging". Optics Express 2023; 31(6), 9739–49. Download PDF
31. Zhang K, Timilsina S, Waguespack M, Kercher EM, Spring BQ. "An open-source LED array illumination system for automated multiwell plate cell culture photodynamic therapy experiments". Scientific Reports 2022; 12, 19341. Download PDF
30. Harman RC, Lang RT, Kercher EM, Leven P, Spring BQ. "Denoising multiplexed microscopy images in n-dimensional spectral space". Biomed Opt Exp 2022; 13(8), 4298–4309. Download PDF
29. Bekker RA, Zahid MU, Binning JM, Spring BQ, Hwu P, Pilon-Thomas S, Enderling H. "Rethinking the immunotherapy numbers game". J Immunother Cancer 2022; 10, e005107. Donwload PDF
28. Lang RT, Spring BQ. "Two-photon peak molecular brightness spectra reveal long-wavelenth enhancements of multiplexed imaging depth and photostability". Biomed Opt Exp 2021; 12(9), 5909–19. Download PDF
27. Kercher EM, Zhang K, Lang RT, Olmos A, Waguespack M, Spring BQ. "High-power light-emitting diode array design and assembly for practical photodynamic therapy research". J Biomed Opt 2020; 25(06), 1. Download PDF
26. Sadiki A, Kercher EM, Lu H, Lang RT, Spring BQ, Zhou ZS. "Site-specific bioconjugation and convergent click chemistry enhances antibody–chromophore conjugate binding efficiency". Photochem Photobiol 2020; 96, 596–603. Download PDF
25. Kercher EM, Spring BQ. "Photodynamic treatments for disseminated cancer metastases using fiber-optic technologies". In Photodynamic Therapy: Methods and Protocols, Methods in Molecular Biology. M Broekaarden, editor. Springer Science+Business Media, New York, 2022. Download PDF
24. Kercher EM, Nath S, Rizvi I, Spring BQ. "Cancer cell-targeted and activatable photoimmunotherapy spares T cells in a 3D co-culture model". Photochem Photobiol 2019; 96(2), 295–300. Download PDF
23. Lang RT, Tatz J, Kercher EM, Palanisami A, Brooks DH, Spring BQ. "Multi-channel correlation improves the noise tolerance of real-time hyperspectral micro-image mosaicking". J Biomed Opt 2019; 24(12): 126002. Download PDF
22. Zhang K, Davoudzadeh N, Ducourthial G, Spring BQ. "Low-cost custom fabrication and mode-locked operation of an all-normal-dispersion femtosecond fiber laser for multiphoton microscopy". J Vis Exp 2019; 153: e60160. Download PDF
21. Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H. "Illuminating the numbers: Integrating mathematical models to optimize photomedicine dosimetry and combination therapies". Front Phys 2019; 7: 46 Download PDF
20. Davoudzadeh N, Ducourthial G, Spring BQ. "Custom fabrication and mode-locked operation of a femtosecond fiber laser for multiphoton microscopy". Sci Rep 2019; 9: 4233. Download PDF
19. Spring BQ, Kessel D. "3D culture models of malignant mesothelioma reveal a powerful interplay between photodynamic therapy and kinase suppression offering hope to reduce tumor recurrence". Photochem Photobiol 2019; 95: 462–3. Download PDF
18. Obaid G, Spring BQ, Bano S, Hasan T. "Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery". J Biomed Opt 2017; 22(12): 121607. Download PDF
17. Spring BQ, Sears RB, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T. "A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways." Nature Nanotechnol 2016; 11: 378–87. Download PDF
16. Tangutoori S, Spring BQ, Mai Z, Mensah L, Palanisami A, Hasan T. "Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic cancer." Nanomedicine: NBM 2016; 12: 223–234. Download PDF
15. Spring BQ, Rizvi I, Xu N, Hasan T. "The role of photodynamic therapy in overcoming cancer drug resistance." Photochem Photobiol Sci 2015; 14: 1476–91. Download PDF
14. Mallidi S, Spring BQ, Chang SK, Vakoc BJ, Hasan T. "Optical imaging, photodynamic therapy and optically-triggered combination treatments." The Cancer Journal 2015; 21(3): 194–205. Download PDF
13. Spring BQ, Palanisami A, Hasan T. "Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy." J Biomed Opt 2014; 19(6): 066006. Download PDF
12. Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T. "Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates." Proc Natl Acad Sci USA 2014; 111(10): E933–42. Download PDF
11. Spring BQ, Palanisami A, Zheng LZ, Blatt AE, Sears RB, Hasan T. "Efficient measurement of total tumor microvascularity ex vivo using a mathematical model to optimize volume subsampling." J Biomed Opt 2013; 18(9): 096015. Download PDF
10. Chen YC, Spring BQ, Clegg RM (2012). "Fluorescence Lifetime Imaging Comes of Age: How to Do It and How to Interpret It." In Spectroscopic Methods of Analysis: Methods and Protocols, Methods in Molecular Biology. WM Bujalowski, editor. Springer Science+Business Media, New York: Volume 875, Chapter 1, 1–22.
9. Kolossov VL, Spring BQ, Clegg RM, Henry JJ, Sokolowski A, Kenis PJ, Gaskins HR. "Development of a high-dynamic range, GFP-based FRET probe sensitive to oxidative microenvironments." Exp Biol Med 2011; 236: 681–91. Download PDF
8. Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe, K, Verma S, Pogue BW, Hasan T. "Imaging and Photodynamic Therapy: Mechanisms, Monitoring and Optimization." Chem Rev 2010; 110(5): 2795–2838. Download PDF
7. Zhong W, Celli JP, Rizvi I, Mai Z, Spring BQ, Yun SH, Hasan T. "In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring." Br J Cancer 2009; 101: 2015–22. Download PDF
6. Spring BQ, Clegg RM. "Image analysis for denoising full-field frequency-domain fluorescence lifetime images." J Microsc 2009; 235(Pt 2): 221–37. Download PDF
5. Spring BQ, Clegg RM (2009). "Frequency-Domain FLIM." In FLIM Microscopy in Biology and Medicine. A Periasamy and RM Clegg, editors. Chapman & Hall/CRC, Boca Raton, FL: Chapter 5, 117–144.
4. Chen YC, Spring BQ, Buranachai C, Tong B, Malachowski G, Clegg RM (2009). "General Concerns of FLIM Data Representation and Analysis: Frequency-Domain Model-Free Analysis." In FLIM Microscopy in Biology and Medicine. A Periasamy and RM Clegg, editors. Chapman & Hall/CRC, Boca Raton, FL: Chapter 11, 291–339.
3. Kolossov VL, Spring BQ, Sokolowski A, Conour JE, Clegg RM, Kenis PJ, Gaskins HR. "Engineering redox-sensitive linkers for genetically encoded FRET-based biosensors." Exp Biol Med 2008; 233: 238–48. Download PDF
2. Spring BQ, Clegg RM. "Fluorescence measurements of duplex DNA oligomers under conditions conducive for forming M-DNA (a metal-DNA complex)." J Phys Chem B 2007; 111: 10040–52. Download PDF
1. Knox RS, Spring BQ. "Dipole strengths in the chlorophylls." Photochem Photobiol 2003; 77: 497–501. Download PDF
