Publications

29. Palanisami A, Spring BQ, Kercher EM, Lang RT, Sutin J, Hasan T. "Sparse-spectral microendoscopy for real-time visualization of tumor cell phenotype and microenvironment spatial heterogeneity in vivo". Nat Biomed Eng. (Submitted).

28. Kercher EM, Zhang K, Lang RT, Olmos A, Waguespack M, Spring BQ. "High-power light-emitting diode array design and assembly for practical photodynamic therapy research". J Biomed Opt 2020; 25(06), 1. Download PDF

27. Kercher EM, Tatz J, Palanisami A, Fang Q, Spring BQ. "Video-rate hyperspectral unmixing for multiplexed microscopy and microendoscopy". Sci Rep. (Accepted pending revisions).

26. Sadiki A, Kercher EM, Lu H, Lang RT, Spring BQ, Zhou ZS. "Site-specific bioconjugation and convergent click chemistry enhances antibody–chromophore conjugate binding efficiency". Photochem Photobiol 2020; [Epub ahead of print]. Download PDF

25. Kercher EM, Spring BQ. "Photodynamic treatments for disseminated cancer metastases using fiber-optic technologies". In Photodynamic Therapy: Methods and Protocols, Methods in Molecular Biology. M Broekaarden, editor. Springer Science+Business Media, New York. (In press).

24. Kercher EM, Nath S, Rizvi I, Spring BQ. "Cancer cell-targeted and activatable photoimmunotherapy spares T cells in a 3D co-culture model". Photochem Photobiol 2019; 96(2), 295-300. Download PDF

23. Lang RT, Tatz J, Kercher EM, Palanisami A, Brooks DH, Spring BQ. "Multi-channel correlation improves the noise tolerance of real-time hyperspectral micro-image mosaicking". J Biomed Opt 2019; 24(12): 126002. Download PDF

21. Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H. "Illuminating the numbers: Integrating mathematical models to optimize photomedicine dosimetry and combination therapies". Front Phys 2019; 7: 46 Download PDF

17. Spring BQ, Sears RB, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T. "A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways." Nature Nanotechnol 2016; 11: 378–87. Download PDF

15. Spring BQ, Rizvi I, Xu N, Hasan T. "The role of photodynamic therapy in overcoming cancer drug resistance." Photochem Photobiol Sci 2015; 14: 1476–91. Download PDF

14. Mallidi S, Spring BQ, Chang SK, Vakoc BJ, Hasan T. "Optical imaging, photodynamic therapy and optically-triggered combination treatments." The Cancer Journal 2015; 21(3): 194–205. Download PDF

13. Spring BQ, Palanisami A, Hasan T. "Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy." J Biomed Opt 2014; 19(6): 066006. Download PDF

12. Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T. "Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates." Proc Natl Acad Sci USA 2014; 111(10): E933–42. Download PDF

11. Spring BQ, Palanisami A, Zheng LZ, Blatt AE, Sears RB, Hasan T. "Efficient measurement of total tumor microvascularity ex vivo using a mathematical model to optimize volume subsampling." J Biomed Opt 2013; 18(9): 096015. Download PDF

10. Chen YC, Spring BQ, Clegg RM (2012). "Fluorescence Lifetime Imaging Comes of Age: How to Do It and How to Interpret It." In Spectroscopic Methods of Analysis: Methods and Protocols, Methods in Molecular Biology. WM Bujalowski, editor. Springer Science+Business Media, New York: Volume 875, Chapter 1, 1–22.

9. Kolossov VL, Spring BQ, Clegg RM, Henry JJ, Sokolowski A, Kenis PJ, Gaskins HR. "Development of a high-dynamic range, GFP-based FRET probe sensitive to oxidative microenvironments." Exp Biol Med 2011; 236: 681–91. Download PDF

8. Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe, K, Verma S, Pogue BW, Hasan T. "Imaging and Photodynamic Therapy: Mechanisms, Monitoring and Optimization." Chem Rev 2010; 110(5): 2795–2838. Download PDF

7. Zhong W, Celli JP, Rizvi I, Mai Z, Spring BQ, Yun SH, Hasan T. "In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring." Br J Cancer 2009; 101: 2015–22. Download PDF

5. Spring BQ, Clegg RM (2009). "Frequency-Domain FLIM." In FLIM Microscopy in Biology and Medicine. A Periasamy and RM Clegg, editors. Chapman & Hall/CRC, Boca Raton, FL: Chapter 5, 117–144.

4. Chen YC, Spring BQ, Buranachai C, Tong B, Malachowski G, Clegg RM (2009). "General Concerns of FLIM Data Representation and Analysis: Frequency-Domain Model-Free Analysis." In FLIM Microscopy in Biology and Medicine. A Periasamy and RM Clegg, editors. Chapman & Hall/CRC, Boca Raton, FL: Chapter 11, 291–339.

3. Kolossov VL, Spring BQ, Sokolowski A, Conour JE, Clegg RM, Kenis PJ, Gaskins HR. "Engineering redox-sensitive linkers for genetically encoded FRET-based biosensors." Exp Biol Med 2008; 233: 238–48. Download PDF

1. Knox RS, Spring BQ. "Dipole strengths in the chlorophylls." Photochem Photobiol 2003; 77: 497–501. Download PDF