Principal Investigator

Bryan Q. Spring, Ph.D.

Assistant Professor

Department of Physics

Northeastern University

Interdisciplinary Science & Engineering Complex (ISEC), Room 314

805 Columbus Ave, Boston, MA 02120

Bryan Q. Spring is an Assistant Professor of Biomedical Physics and an Affiliated Faculty of Bioengineering (Northeastern University, Boston), and a Visiting Scientist at the Wellman Center for Photomedicine (Massachusetts General Hospital and Harvard Medical School). As an undergraduate NSF fellow, he contributed to characterizing one of the intricate photophysical parameters of Förster resonance energy transfer (FRET) under the guidance of Robert S. Knox (Department of Physics, University of Rochester, NY). His doctoral work with Robert M. Clegg (Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign) focused on developing fluorescence lifetime and quantitative FRET imaging. He developed patent pending technology for molecular imaging and selective treatment of cancer micrometastases during his postdoctoral fellowship in Tayyaba Hasan’s laboratory (Wellman Center for Photomedicine).

Postdoctoral Fellows

Dr. Nima Davoudzadeh

Ph.D., Southern Illinois University (Carbondale), 2014

Nima's research interests include lasers, photonic circuit design and fabrication, and imaging systems. He joined the Spring Lab as a postdoctoral fellow in 2016 to design and implement fiber-based femtosecond lasers suitable for two and three photon imaging of microscopic disease. These innovative lasers are characterized by their multi-wavelength, femtosecond pulses that propagate entirely within a fiber ring and are ideal for low-cost and compact multiphoton endoscopy.

Previously, Nima was a postdoctoral scholar at the Photonic Systems Lab (University of Illinois at Urbana-Champaign), where he focused on utilizing both the thermal bi-stability of Si3N4 and the Kerr Effect nonlinearity of LiNbO3 micro-ring resonators to implement an optical clock pulse generator and an optical analog to digital (A/D) converter. One highlight of these novel schemes was a significant enhancement of the micro-ring resonator quality factor (Q).

Nima's Ph.D. dissertation focused on the design and implementation of an Optical Binary Delta Sigma Modulator (OBDSM) system, suitable for modulating high frequency signals (RF) with high modulation depth. This research resulted in the invention of an all-optical reverse Schmitt triggering technique for compensating delays (e.g., feedback delay or switching relaxation time) in photonic systems, while cancelling out hysteretic behavior.

While completing his Master’s degree, he designed a custom Plasma Enhanced Chemical Vapor Deposition (PECVD) system for growing carbon nanotubes (CNTs) vertically. This fully automated PECVD enables user selectable temperature, gas flow, and plasma power, which reduces operational error and produces more consistent processed materials. The PECVD also operates at a lower growth temperature (around 350°C), which directly increases product quality and better CNT alignment.

Graduate Students

Eric Kercher

Doctoral Candidate, Physics, Northeastern University

B.S. Physics, Rose-Hulman Institute of Technology, 2015

Eric's interdisciplinary research career led him to join the Spring Lab in 2016, where he has been involved in many projects, and is currently spearheading our efforts to learn about and characterize specific phenotypes within a heterogeneous culture of cancer cells. Eric is primarily interested in developing translatable cancer therapies by combining his experience in fundamental photophysics, medical imaging, and cancer biology. Eric will also receive a Certificate in Nanomedicine through the Nanomedicine Academy as part of his doctoral training, and hopes to use these concepts to create new nanomedicines later in his career. In 2015, Eric completed the Pediatric Oncology Education (POE) program at St. Jude Children's Research Hospital where he worked on hepatic iron quantification using MRI in the Diagnostic Imaging Department. He enjoys running, cycling, and watching sports in his spare time.

Rebecca Harman

Doctoral Candidate, Physics, Northeastern University

B.S. Physics, Harvey Mudd College, 2017

Rebecca joined the Spring Lab in early 2019. She is investigating new approaches to tumor-targeted, activatable photomedicine and precision microsurgery that address heterogenous deposits of cancer cells missed by standard therapies. As an undergraduate at Harvey Mudd College, she completed a senior thesis project applying single-molecule super-resolution microscopy to study the huntingtin protein aggregation associated with the genetic mutation that causes Huntington's disease. Rebecca aims to become a professor and to pursue a research career in interdisciplinary biomedical physics and biophysical microscopy.

Ryan Lang

Doctoral Candidate, Physics, Northeastern University

B.S. Physics, Worcester Polytechnic Institute, 2016

Ryan joined the Spring Lab in 2017 via the graduate summer fellowship program hosted by the Physics Department. His projects include characterizing multi-photon cross-sections of many common fluorophores to fill in gaps in the literature (particularly beyond 1000 nm). He is also developing mosaicking algorithms for real-time hyperspectral imaging systems. He completed his B.S. program in Physics at Worcester Polytechnic Institute in 2016, where he focused his studies in Optics, Photonics, and Lasers. His work culminated in his Major Qualifying Project "Listening to Light" in which he worked with another student to design and implement a device to distinguish an objects color and relay the color aurally.

Kai Zhang

Doctoral Candidate, Physics, Northeastern University

B.S. Physics, University of Minnesota, 2015

Kai is a recipient of the Physics Department's graduate summer fellowship and joined the Spring lab in 2017 with a primary focus on multi-channel, gigahertz data acquisition and signal processing using state-of-the-art FPGA technology, with applications to hyperspectral and fluorescence lifetime-resolved microscopy. After receiving his undergraduate degree from the University of Minnesota in 2015, he returned to China for a year to teach high school physics. He began Northeastern's Ph.D. program in 2016 and aspires to become a professor after graduation.

Matthew Waguespack

Doctoral Candidate, Physics, Northeastern University

B.S. Physics, East Carolina University, 2016

Matt joined the Spring Lab in 2018 with a focus on tumor cell ablation and the feasibility of femtosecond microsurgery. He is also creating a Monte Carlo program for mapping photon delivery in the tumor microenvironment. Matt graduated with a B.S in Physics from East Carolina University in 2016 where he studied optically stimulated luminescence leading to the development of a device to detect absorbed radiation within teeth.

Arvind Mohan

M.S. Student in Bioengineering, Northeastern University

B.E. in Electrical and Electronics Engineering, BITS Pilani, 2016

Arvind joined the Spring Lab in the spring of 2018 as an instrumentation specialist. He will be working on the development of a laser-scanning, multi-photon, and microendoscopic probe for his masters thesis project. He completed his Bachelors of Engineering in Electrical and Electronics Engineering at Birla Institute of Technology and Science Pilani, India in 2016 where he worked on imaging malarial parasite detection in stained blood smear images. Arvind is a recipient of the KVPY Scholarship, a fellowship bestowed by the Government of India for Excellence in Science. Arvind wishes to work in research regarding imaging techniques for cancer and diabetes in the future. In his free time Arvind enjoys playing the violin and is an avid football fan.

Co-op Students

Alejandro Olmos

Northeastern University, Health Sciences, 2022

Alejandro is a third year undergraduate majoring in Health Sciences and following a pre-medicine track. He joined the Spring Lab in the Fall of 2018 and his work has focused on preclinical tumor culture models. Presently, Alejandro is exploring several resistance mechanisms of cancer cells in two- and three-dimensional culture models to create new models of chemoresistant ovarian cancer. In his spare time, he enjoys piloting small planes, exploring new restaurants, and traveling.

Undergraduate Students

Anna McIntyre

Northeastern University, Biochemistry, 2020

Anna is currently pursuing her bachelor’s in Biochemistry at Northeastern University. She plays a critical role in advancing our cell culture lab. In addition to volunteering in the Spring Lab, she is also involved in a research project at JFK Medical Center working in the Sleep Medicine department. In her spare time she enjoys swimming, running, and teaching fitness classes. Anna hopes to pursue a career in medicine following her undergraduate career.

Lauren Herschelman

Northeastern University, Bioengineering, 2020

Lauren joined the Spring lab after receiving the Undergraduate Women in Physics award for undergraduate research. She presently contributes to the cell culture team to develop and characterize new models of chemoresistant disease. Lauren plans to attend medical school after graduation. Outside of the lab, she enjoys running and eating lots of food.

Sophia Renauld

Northeastern University, Physics, 2021

Sophia is a first year Biomedical Physics major at Northeastern University. She joined the lab in winter of 2018 as member of our cell culture team. She plans to leverage this research experience to guide her future career path in medicine. In her free time, she works as a ski instructor and soccer coach.

Jen Selingo

Northeastern University, Physics, 2020

Jen is a second year Applied Physics major who has been a member our PDT team since January 2018. She has contributed to the design and implementation of a high-power LED array, central to the lab's low-cost PDT system. Jen aims to attend graduate school to pursue a career as a medical physicist. Some of her hobbies include playing the guitar and listening to her vinyl record collection.

Julia Tatz

Northeastern University, Physics, 2019

Ji Tae Park

Northeastern University, Pharmacy, 2022

Ji Tae is a fourth year undergraduate student in the six-year Pharmacy Doctorate (PharmD) program who is also minoring in physics. Having always been interested in applying physics to pharmacology/medicine, he joined the Spring Lab in the Summer of 2019. Currently, he is working with our graduate students (Kai and Arvind) to explore the applicability of femtosecond fiber laser to microendoscopy in clinical settings. He plans to attend graduate school upon graduation to further study biophysics. He is also a breakdancer and a passionate fan of Chelsea, an English Premier League soccer team.

Jiasen Hou

Northeastern University, Applied Physics, 2020


Dr. Guillaume Ducourthial

Ph.D. in Photonics Systems, University of Limoges, France, 2014

Guillaume brought his expertise in photonic and fiber-optic systems to our lab in 2016 to lead development of a low-cost, all-fiber multi-photon imaging device. This miniaturized fiber scanning probe is designed to simultaneously deliver femtosecond pulses for multi-photon excitation and collect hyperspectral fluorescence emission at rates of 15 frames per second or greater (i.e., video rate acquisition).

Formerly, Guillaume's Ph.D. work at XLIM concerned the development of new fiber-optic imaging tools based on multi-photon responses. He successfully verified the feasibility of a fiber-optic multi-photon microscope with characteristics on par with those of a commercial device, and continued on to miniaturize this microscope in order to obtain a flexible multi-photon microendoscope compatible with in vivo imaging. Guillaume also held a postdoctoral position at the Laboratoire d’Optique et Bioscience (Palaiseau, France), where he implemented a fast polarization modulation system to study the effect of mechanical stresses on biological tissues using Second Harmonic Generation microscopy in living samples.

Gabby Brauner

Northeastern University, Health Science, 2018

Gabby joined the Spring Lab as a co-op student through the CaNCURE program, and was instrumental in setting up our lab and helping perform our cell culture experiments. After her co-op, she continued her work characterizing chemo-resistant ovarian cancer cell lines for her senior capstone project. She is a pre-med student who is starting medical school in the Fall of 2018. Previously, she worked at Brigham and Women’s Hospital in the Comprehensive Breast Center as a medical assistant. Outside of the lab, Gabby enjoys running and taking spin classes.