Miles was born to an African-American father and a Puerto Rican mother. Miles was born and raised in Brooklyn and has a aptitude for science much like his predecessor, Peter Parker. Miles, after being awarded the final spot in a Charter School Lottery, visited his Uncle Aaron, against his parents' wishes. While they discussed the opportunities that the school could open to him, the Oz-enhanced spider emerged from Aaron's bag and bit Miles on his hand, causing him to pass out and foam at the mouth. Later, when Miles awoke, Aaron was confronted by Miles' father. During a brief confrontation, Miles fled from Aaron's apartment. While hiding from his father on the street, Miles realized that he was starting to become invisible.