Training and Education
2018 - till date Postdoctoral Fellow in Evolutionary Biophysics, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
Advisor: Prof. Eugene. I. Shakhnovich, Professor of Chemistry & Chemical Biology
Tenure: August 2018, till date
July 2022 - till date Associate Fellow, Harvard Program in Therapeutic Sciences, Harvard Medical School, Longwood, Boston, Massachusetts, USA.
2019 Ph.D. in Biochemistry/Bio-physical Chemistry, CSIR-Indian Institute of Chemical Biology, Kolkata, India
Thesis: Dynamics and Conformational Study of Beta Sheet Model Proteins in vitro and in cultured cells.
Thesis Advisor: Prof. Krishnananda Chattopadhyay, Head, Structural Biology and Bio- informatics division, CSIR-IICB
Ph.D. tenure: Aug 2013 to May 2018 (Thesis submitted); April 2019 (Degree Awarded)
2012 M.Sc. Biotechnology, Department of Biotechnology Fellow, Utkal University, Bhubaneswar, India
Department of Biotechnology, Govt. of India, Course Program
Selected through JNU (Jawaharlal Nehru University) All India Combined Entrance Examination for Biotechnology, CEEB 2010
First Class
2010 B.Sc. Microbiology (Honors), University of Calcutta, India
First Class
Awards
Research Excellence award for outstanding research activity in Ph.D. CSIR-Indian Institute of Chemical Biology, March 2018
Best Poster Award, International Conference on Intrinsically Disordered Proteins, IDP 2017, Centre for Protein Science, Design and Engineering, Indian Institute of Science Education and Research, Mohali. Dec 2017
Carl Storm International Diversity Award Fellowship, Gordon Research Conference (Protein Folding and Dynamics Session), Jan 2018
Finalist Speaker award, 3Rs in Biophysics MAWA (medical advances in Bio- physics) at 19th IUPAB and 11th EBSA congress, July 2017
Travel Awards
IUPAB Early Career Young Scientist Travel Award for attending and presenting at 19th IUPAB & 11th EBSA congress, Edinburgh, UK, 2017
Department of Biotechnology (DBT), Govt. Of India, International Travel Grant for presenting works at the 19th IUPAB and 11th EBSA congress at Edinburgh, UK. July 2017
Fellowships
NIH Post-Doctoral Fellowship, Faculty of Arts and Science, Harvard University, USA
UGC Senior Research Fellowship (Ph.D. studies) 2015
UGC Junior Research Fellowship (Ph.D. studies) 2013
DBT Fellowship (M.Sc. studies) 2010-2012
DBT BCIL Fellowship (Post M.Sc. internship) 2012-2013
PRESENTATIONS
Invited Lectures
An Evolution and Structure Guided Framework to Interpret the Intracellular Mechanism of Action of Prospective Drug Candidates for Neurodegenerative Disease, Lab of Systems Pharmacology, HiTS (Harvard Program in Therapeutic Sciences), Harvard Medical School, Longwood. November 18, 2022.
Evolution and Structure guided Framework to identify molecular off-targets for prospective drug candidates for neurodegenerative diseases, Massachusetts General Hospital and Partners Talk Series. June 22nd, 2022.
Lightening Talk. “Interpreting the intracellular mechanism of action of prospective drug candidates for neurodegenerative diseases using an evolution and structure guided framework”. Lab of Systems Pharmacology, HiTS (Harvard Program in Therapeutic Sciences), Harvard Medical School, Longwood. May 13th, 2022.
A native chemical chaperone in human lens, Center for nano-scale systems (CNS), Harvard University, April 1, 2022 (co presented with Dr. Eugene Serebryany)
Development of evolution-informed antibacterial compounds that block pathways to resistance, Beth Israel Deaconess Medical Center, Harvard Medical School, February 17, 2022
Lightening Talk. “An Evolution and Structure guided approach to demystify the “off-target identification” problem of prospective drug candidates for neurodegenerative diseases”. Lab of Systems Pharmacology, Harvard Medical School, Longwood. December 3rd, 2021.
From Folding Landscape to Evolutionary Fitness Landscape, Massachusetts General Hospital Partners Meet, Harvard Medical School, July 14, 2021
Challenges in research during the pandemic & a mechanistic insight into the evolutionary trail & the structural facets of spike receptor binding domain of SARS-COV-2, web-seminar, University Grants Commission, Govt. of India and HMM College, West Bengal State University, July 6, 2020
Frontiers of Protein Folding, Outreach Talk (DBT, Govt. of India Session for Igniting young M.Sc. minds), Post Graduate Department of Biotechnology, Utkal University, Bhubaneswar. February 2018.
Unraveling metal induced orchestration of conformational landscape of Cu/Zn SOD with its implications in ALS. Young investigators talk, International Conference on “Neurodegenerative Disorders: Current and Future Perspective.” Hosted jointly by Institute of Neurosciences, Newcastle University and University of Calcutta, February 2017
Life through the prism of Evolution, Post Graduate Department of Biotechnology, Utkal University, Bhubaneshwar, Odisha, India, February 26, 2022
Conference Talks
Development of evolution drugs - antibacterial compounds that block pathways to resistance and a systems-guided approach to explore its intracellular targeting. Annual Symposium Full Research Talk, Department of Chemistry and Chemical Biology, Faculty of Arts and Science, Harvard University, Cambridge, MA, USA May 18, 2021
A synergy of in-silico and in-vitro probation to unravel the seeding events of SOD1 aggregation with implications in ALS 3Rs and Biophysics, MAWA (medical advances without animals) session, 19th IUPAB and 11th EBSA congress, Edinburgh, UK, July 2017
Exploring the hidden trails of Beta sheet proteins CSIR-Indian Institute of Chemical Biology Research Festival 2016
Exploring the Effect of Membrane Microdomain on Lipid Binding Protein-Ligand Association- A FCS and Confocal Microscopic Study, Annual Meet of Society of Biological Chemists (India), Kolkata chapter and Symposium on Recent Trend in Biological Chemistry, Sankarpur, West Bengal, India, April 2015.
Posters & Abstracts
Session member Crystallin-Biophysics Workshop, BPS February 2021
International Conference on Intrinsically Disordered Proteins, IDP2017 at Indian Institute of Science Education and Research, IISER, Mohali. Dec 2017.
Gordon Research Conference on Protein Folding and Dynamics, Galveston, Texas, USA. January 2018
Session member: “Bio-physics in 21st Century” 19th IUPAB satellite session. Edinburgh, Scotland, UK. July 2017
19th International Union for Pure and Applied Biophysics and 11th EBSA Congress at Edinburgh, UK. July 2017
3rd International Conference on Protein Folding and Dynamics, November 2016, National Centre for Biological Sciences (TIFR-NCBS), Bangalore, India
CSIR Indian Institute of Chemical Biology Translational Research Unit of Excellence inaugural scientific session February 2016
14th International FAOBMB Congress and 84th Annual Meeting of SBC (India), November 2015, CCMB Hyderabad and BITS Hyderabad
National Workshops on Fluorescence and Raman Techniques, FLUORA 2014, at Indian Institute of Science Education and Research, IISER, Pune
Public Outreach talks
Covid 19 vaccination and immune escape variants- Bringing Darwinism to all, Uttor Kolkata Baulana Folk Welfare Society, Registered with NITI AYOG , June 6th 2021
Honors and Competitive Examinations
Joint CSIR (Council of Scientific and Industrial Research, Ministry of Human Resource Development, Govt. of India) -UGC (University Grants Commission) NET (National Eligibility Test) December 2012. All India Rank: UGC JRF 66 . Ph.D. fellowship 2013 to 2018
Graduate aptitude test of Engineering (GATE) 2013 conducted by Indian Institute of Technology, Bombay. Percentile: 98.18 (Life Science).
Joint CSIR (Council of Scientific and Industrial Research, Ministry of Human, Govt. Of India) -UGC (University Grants Commission) NET (National Eligibility Test) June 2012. All India Rank: Lectureship (Ls.) 36
Joint CSIR (Council of Scientific and Industrial Research, Ministry of Human Resource Development, Govt. Of India) -UGC (University Grants Commission) NET December 2011. All India Rank: Lectureship (Ls.) 28
Graduate aptitude test of Engineering (GATE) 2012 conducted by Indian Institute of Technology, Madras. Percentile: 97.88 (Life Science).
Reviewer:
Nature Communication Biology
Nature Scientific Reports
Entropy
International Journal of Molecular Sciences
Microorganisms
Catalysts