A few details

The development of the brain is a very complex process that requires a  highly regulated sequences of steps and precise modulation of gene expression. In our lab we use the fruit fly, Drosophila melanogaster as a model to  understand the contribution of post-transcriptional regulation of gene expression during neurodevelopment and, in particular, the role of the epitranscriptomic mark N6-methyladenosine (m6A) .

Lifespan and aging are modulated by serveral genetic and environmental conditions and the specific mechanisms underlying this process are still largely unknown.  The fruit fly is a perfect model to investigate aging, due to the conservation of genetic and molecular pathways and short lifespan. In the lab we are particularly interested in understanding the connection between transcriptomic changes and healthy aging and the involvement of the epitranscriptomic mark N6-methyladenosine (m6A).

Alzheimer’s disease is the most common form of dementia, characterized by extensive neuronal death, synapse loss and cognitive deficits.  Despite the extensive research, the pathological mechansisms underlying this disease are still elusive and a cure is still lacking. Our lab is interested in studying the role of neuroinflammation in Alzheimer's disease, by using different Drosophila genetic models that will allow us to understand how neuroinflammation develops in vivo and the signalings involved in this process.