2023

Austin C. Boese*, JiHoon Kang*, Jung Seok Hwang*, Jaehyun Kim, Kiyoung Eun, Courteney M. Malin, Kelly R. Magliocca, Chaoyun Pan, Lingtao Jin, and Sumin Kang. (2023) Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis. Proc Natl Acad Sci USA 120(23), e2217332120. doi: 10.1073/pnas.2217332120.

2022

JiHoon Kang, Jaemoo Chun, Jung Seok Hwang, Chaoyun Pan, Jie Li, Austin C. Boese, Isabelle Young, Courteney M. Malin, Yibin Kang, Don L. Gibbons, Gabriel Sica, Haian Fu, Suresh S. Ramalingam, Lingtao Jin, and Sumin Kang. (2022) EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer. Cell Reports  41(11), 111827. doi: 10.1016/j.celrep.2022.111827.

Austin C. Boese*, Jung Seok Hwang*, Isabelle Young*, Courteney M. Malin, Vanessa Avalos, JiHoon Kang, and Sumin Kang. (2022) Metabolic inhibitor screening identifies dihydrofolate reductase as an inducer of the tumor immune escape mediator CD24. ImmunoMedicine  2(2):e1041. doi: 10.1002/imed.1041.

2021

Chaoyun Pan, JiHoon Kang, Jung Seok Hwang, Jie Li, Austin C. Boese, Xu Wang, Likun Yang, Titus J. Boggon, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Lingtao Jin, and Sumin Kang. (2021) Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1. Nature Communications  2(1):4960. doi: 10.1038/s41467-021-24845-8.

Austin C. Boese and Sumin Kang. (2021) Mitochondrial metabolism-mediated redox regulation in cancer progression. Redox Biology  42, 101870. https://doi.org/10.1016/j.redox.2021.101870

2020

Jie Li, Chaoyun Pan, Austin C. Boese, JiHoon Kang, Anna D. Umano, Kelly R. Magliocca, Wenqing Yang, Yu Zhang, Sagar Lonial, Lingtao Jin and Sumin Kang. (2020) DGKA provides platinum resistance in ovarian cancer through activation of cJUN-WEE1 signaling. Clin Cancer Res  26(14), 3843-3855. 

Austin C. Boese and Sumin Kang. (2020) Tumor progression of breast cancer during hyperinsulinemic obesity. Trends Mol Med  26(4),354-356.

2019

Chaoyun Pan, Jaemoo Chun, Dan Li, Austin C. Boese, Jie Li, JiHoon Kang, Anna Umano, Yunhan Jiang, Lina Song, Kelly R. Magliocca, Zhuo G. Chen, Nabil F. Saba, Dong M. Shin, Taofeek K. Owonikoko, Sagar Lonial, Lingtao Jin, and Sumin Kang. (2019) Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteasomal degradation. J Clin Invest  129(10), 4110-4123

Chaoyun Pan, Lingtao Jin, Xu Wang, Yuancheng Li, Jaemoo Chun, Austin C. Boese, Dan Li, Hee-Bum Kang, Guojing Zhang, Lu Zhou, Georgia Z. Chen, Nabil F. Saba, Dong M. Shin, Kelly R. Magliocca, Taofeek K. Owonikoko, Hui Mao, Sagar Lonial, and Sumin Kang. (2019) Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest  129(6), 2431-2445

Fang Ni, Wen-Mei Yu, Zhiguo Li, Douglas K. Graham, Lingtao Jin, Sumin Kang, Michael R. Rossi, Shiyong Li, Hal E. Broxmeyer, and Cheng-Kui Qu. (2019) Critical role of ASCT2-mediated amino acid metabolism in promoting leukemia development and progression. Nature Metabolism 1, 390-403

2018

Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. Boise, Taofeek K. Owonikoko, Fadlo R. Khuri, Kelly R. Magliocca, Dong M. Shin, Sagar Lonial, and Sumin Kang. (2018) MAST1 drives cisplatin resistance in human cancers by rewiring cRaf independent MEK activation. Cancer Cell  34(2), 315-330

Preview: Pulling a MAST1 on cisplatin resistance. Ankita B. Jaykumar, Aroon S. Karra, Melanie H. Cobb (2018) Cancer Cell  34 (2),183-185

Research Highlights: Synthetic lethality with cisplatin. Leslie K. Ferrarelli (2018) Sci Signal 11 (544), e1294

*Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Avi Kumar, Guojing Zhang, Youna Ha, Dan Li, Gina N. Alesi, Yibin Kang, Lu Zhou, Wen-Mei Yu, Kelly R. Magliocca, Fadlo R. Khuri, Cheng-Kui Qu, Christian Metallo, Taofeek K. Owonikoko, and *Sumin Kang. (2018) The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Molecular Cell  69(1), 87-99

Research Watch: Glutaminolysis drives lung cancer metastasis via the PLAG1-GDH1 axis (2018) Cancer Discovery [published online]

Preview: Glutamate dehydrogenase to the rescue. Jonathan L. Coloff (2018) Molecular Cell 69 (1), 1-2

Hong Zheng, Wen-Mei Yu, Jinhua Shen, Sumin Kang, Dolores Hambardzumyan, Jaems Y. Li, Yuxian Shen, Anna M. Kenney, Jing Chen, and Cheng-Kui Qu. (2018) Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development. Science Advances 4(10), eaat2681

Lijun Wang, Caterina Iorio, Kevin Yan, Howard Yang, Sunao Takeshita, Sumin Kang, Benjamin Neel, and Wentian Yang. (2018) A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI-3 kinase/AKT activation in macrophages. FASEB J  32(2), 875-887 

2017

Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Gina N. Alesi, Dan Li, Kelly R. Magliocca, Yibin Kang, Zhuo G. Chen, Dong M. Shin, Fadlo R. Khuri, Jun Fan and Sumin Kang. (2017) Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumor metastasis. Oncogene 36(27), 3797-3806  

2016

Gina N. Alesi, Lingtao Jin, Dan Li, Kelly R. Magliocca, Yibin Kang, Zhuo G. Chen, Dong M. Shin, Fadlo R. Khuri, and Sumin Kang. (2016) RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis. Oncogene 35(41), 5412-5421

Lingtao Jin, Gina N. Alesi, and Sumin Kang. (2016) Glutaminolysis as a target for cancer therapy. Oncogene  35(28), 3619-3625   

Jun Fan, Ruiting Lin, Siyuan Zia, Dong Chen, Shannon E. Elf, Shuangping Liu, Yaozhu Pan, Haidong Xu, Zhiyu Qian, Mei Wang, Changliang Shan, Lu Zhou, Qun-Ying Lei, Yuancheng Li, Hui Mao, Benjamin H. Lee, Jessica Sudderth, Ralph J. DeBeradinis, Guojing Zhang, Taofeek Owonikoko, Manila Gaddh, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Sumin Kang, Paul W. Doetsch, Sagar Lonial, Titus J. Boggon, Walter J. Curran and Jing Chen. (2016) Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth. Molecular Cell 64(5), 859-874

2015

Lingtao Jin, Dan Li, Gina N. Alesi, Jun Fan, Hee-Bum Kang, Zhou Lu, Titus Boggon, Peng Jin, Hong Yi, Elizabeth R. Wright, Duc Duong, Nicholas T. Seyfried, Robert Egnatchik, Ralph J. DeBerardinis, Kelly M. Magliocca, Chuan He, Martha L. Arellano, Hanna J. Khoury, Dong M. Shin, Fadlo R. Khuri, and Sumin Kang. (2015) Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell  27(2), 257-270

Ruiting Lin, Shannon Elf, Changliang Chan, Hee-Bum Kang, Quanjiang Ji, Lu Zhou, Taro Hitosugi, Liang Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Matthew Mitsche, Ralph DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng Chen, Dongsheng Wang, Zhuo Georgia Chen, Sagar Lonial, Martha Arellano, Hanna Khoury, Fadlo Khuri, Benjamin Lee, Daniel Brat, Keqiang Ye, Titus Boggon, Chuan He, Sumin Kang*, Jun Fan*, and Jing Chen* (2015) 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol  17(11), 1484-1496 *Corresponding authors

Hee-Bum Kang, Jun Fan, Luiting Lin, Shannon Elf, Quanjiang Ji, Jae Ho Seo, Jack Arbiser, Cynthia Cohen, Daniel Brat, Henry M. Miziorko, Eunhee Kim, Omar Abdel-Wahab, Taha Merghoub, Stefan Fröhling, Claudia Scholl, Pablo Tamayo, David A. Barbie, Lu Zhou, Brian P. Pollack, Kevin Fisher, Ragini R. Kudchadkar, David H. Lawson, Michael Rossi, Sagar Lonial, Hanna Khoury, Fadlo Khuri, Benjamin H. Lee, Titus J. Boggon, Chuan He, Sumin Kang* and Jing Chen* (2015) Oncogenic BRAF V600E requires ketone body acetoacetate to enhance MEK1 activation. Molecular Cell  59(3), 552-565 *Corresponding authors

Research highlights: Mutant BRAF feels the burn. Nicola McCarthy. (2015) Nat Rev Cancer 15, 454-455

Preview: Addicted to AA (Acetoacetate): A point of convergence between metabolism and BRAF signaling. Sebastian Trousil and Bin Zheng. Molecular Cell 59(3), 333-334

Research Watch: Ketogenesis drives BRAF-MEK1 signaling in BRAFV600E-positive cancers (2015) Cancer Discovery [published online]

2014

Jun Fan, Hee-Bum Kang, Changliang Shan, Shannon Elf, Ruiting Lin, Jianxin Xie, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Tae-Wook Chung, Martha Arellano, Hanna J. Khoury, Dong M. Shin, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, and Jing Chen (2014) Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect. J Biol Chem 289(38), 26533-26541

Changliang Shan, Shannon Elf, Quanjiang Ji, Hee-Bum Kang, Lu Zhou, Taro Hitosugi, Lingtao Jin, Liang Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng Chen, Dongsheng Wang, Georgia Zhuo Chen, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, and Jing Chen. (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth Molecular Cell  55(4), 552-565

Fan, J., Shan, C., Kang, H.-B., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. (2014) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell  53(4), 534-548

2013

Dan Li, Lingtao Jin, Jun Fan, Jae Ho Seo, Dongsheng Wang, Meghan Tucker, Ting-Lei Gu, Benjamin H. Lee, Zhou G. Chen, Jack Taunton, Dong M. Shin, Fadlo R. Khuri, and Sumin Kang. (2013) The pro-metastatic Ribosomal S6 Kinase 2-cAMP Response Element-binding Protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein Fascin-1 to promote tumor metastasis. J Biol Chem 288(45), 32528-32538

Lingtao Jin, Dan Li, Jong Seok Lee, Shannon Elf, Gina N. Alesi, Jun Fan, Hee-Bum Kang, Dongsheng Wang, Titus Boggon, Haian Fu, Jack Taunton, Meghan Tucker, Ting-Lei Gu, Zhou G. Chen, Dong M. Shin, Fadlo R. Khuri, and Sumin Kang. (2013) p90RSK2 mediates anti-anoikis signals by both transcription-dependent and -independent mechanism. Mol Cell Biol  33(13), 2574-2585 Pubmed Link

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H.B., Seo, J.H., Shan, C., Dai, Q., Xie, J., Gu, T,-L., Jin, P., Alecovic, M., LeRoy, G., Kang, Y., Sudderth, J.A., DeBerardinis, R.J., Luan, C., Lonial, S., Arellano, M.L., Khoury, H.J., Khuri, F.R., Lee, B.J.,Ye, K., Boggon T.J., Kang, S., Chuan, H., and Chen, J. (2013) Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation Nat Commun 4(1790), doi:10.1038/ncomms2759 

2012

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H.B., Seo, J.H., Shan, C., Dai, Q., Xie, J., Gu, T,-L., Jin, P., Alecovic, M., LeRoy, G., Kang, Y., Sudderth, J.A., DeBerardinis, R.J., Luan, C., Lonial, S., Arellano, M.L., Khoury, H.J., Khuri, F.R., Lee, B.J.,Ye, K., Boggon T.J., Kang, S., Chuan, H., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis by controlling intracellular levels of 3-phosphoglycerate and 2-phosphoglycerate. Cancer Cell  22(5), 585-600

Nathan N. Gushwa, Sumin Kang, Jing Chen, and Jack Taunton. (2012) Selective targeting of distinct active site nucleophiles by irreversible src-familiy kinase inhibitors. J Am Chem Soc 134(50), 20214-20217

2011

Hitosugi, T., Fan, J., Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S.*, and Chen, J*. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell  44(6), 864-877 *Corresponding  authors Pubmed Link

Preview: Flinking the Warburg Switch-Tyrosine Phosphorylation of Pyruvate dephydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells. Schulze, A. and Downward, J. (2011) Molecular Cell  44(6), 846-848 

Fan, J., Hitosugi, T., Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumour growth. Mol Cell Biol  31(24), 4938-4950 Pubmed Link 

Benjamin H. Lee and Sumin Kang. (2011) Targeting RSK2 in myeloid leukemia: right for FLT3 but wrong for BCR-ABL. Cell Cycle 10(21), 3611-3612 Pubmed Link

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor Williams, Benjamin Lee, Warren Leonard, Jack Taunton, Hanna J. Khoury, and Sumin Kang*. (2011) p90RSK2 is essential for FLT3-ITD-, but dispensable for BCR-ABL-induced myeloid leukemia. Blood  117(25), 6885-6894 Pubmed Link   

Sumin Kang and Jing Chen. (2011) Targeting RSK2 in human malignancies. Expert Opin  Ther Targets 15(1), 11-20 PubMed Link PDF 

Masayasu Otsuka, Masao Mizuki, Jiro Fujita, Sumin Kang, and Yuzuru Kanakura. (2011) Constitutive Active FGFR3 with Lys650Glu Mutation Enhances  the Bortezomib Sensitivity in Plasma Cell in malignancy. Anticancer Research 31(1), 113-122 PubMed Link

2010 

Oh, Y., Liu, X., Yue, P., Kang, S., Chen, J., Taunton, J., Khuri, F.R., and Sun, S.Y. (2010) ERK/RSK signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem  285(53), 41310-41319 PubMed Link 

Sumin Kang*, Shannon Elf, Katherine Lythgoe, Taro Hitosugi, , Jack Taunton, Wei Zhou, Li Xiong, Dongsheng Wang, Susan Muller, Ting-Lei Gu, Roberto D.  Polakiewicz, Zhuo (Georgia) Chen, Fadlo R. Khuri, Dong M. Shin, and Jing Chen*. (2010) RSK2 promotes head and neck cancer cell invasion and tumor  metastasis. J Clin Invest 120(4), 1165-1177  *Corresponding authors Pubmed Link 

2009 

Taro Hitosugi, Sumin Kang, Tae-Wook Chung, Matthew G. Vander Heiden, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus J. Boggon, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, and Jing Chen. (2009) Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumour growth. Science Signaling 2(97), Ra73 PubMed Link

Preview: PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a different View of the Warburg Effect. Dang, C.V. (2009) Science Signaling 2(97), pe75 

Sumin Kang, Shannon Elf, Shaozhong Dong, Taro Hitosugi, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Jean Khoury, Ifor R. Williams, Benjamin H. Lee, Johannes L. Roesel,  Gerard Karsenty, André Hanauer, Ting-Lei Gu, and Jing Chen. (2009) FGFR3 associates with and tyrosine-phosphorylates p90RSK2, leading to RSK2 activation that mediates  hematopoietic transformation. Mol Cell Biol  29(8), 2105-2117 PubMed Link 

CB Chan, X Liu, S-W Jang, SI-H Hsu, I Williams, S Kang, J Chen, and K Ye. (2009) NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 asscoiation. Oncogene 28(43), 3825-3836 PubMed Link 

Sumin Kang, Seong-Jun Kim, Jung-Hee Kim, Wooseong Lee, Geon-Woo Kim, Kee-Ho Lee, Kang-Yell Choi, and Jong-Won Oh. (2009) Interaction of Hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis. Cancer Lett 279(2), 230-237  PubMed Link

2008 

Sumin Kang, Shaozhong Dong, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Jean Khoury, Ting-Lei Gu, and Jing Chen. (2008) EGF stimulates RSK2 activation through activation of  the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529. J Biol Chem 283(8), 4652-4657 PubMed Link

Shaozhong Dong, Sumin Kang, Sagar Lonial, Hanna Jean Khoury, Jean Viallet, Jing Chen. (2008) Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070. Leukemia 22(3), 572-577 PubMed Link

2007 

Sumin Kang, Shaozhong Dong, Ting-lei Gu, Ailan Guo, Michael S. Cohen, Sagar Lonial, Hanna Jean Khoury, Doriano Fabbro, D. Gary Gilliland, P. Leif Bersagel, Jack Taunton, Roberto D. Polakiewicz, and Jing Chen. (2007) FGFR3 activates RSK2 to mediate hematopoietic transformation through both tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell 12(3), 201-214 PubMed Link

Preview: New Insights into RSK activation and Hematopoietic Cancer. Cuadrado, A. and Nebreda, A.R. (2007) Cancer Cell 12(3), 187-188  

Shaozhong Dong, Sumin Kang, Tinglei Gu, Sean Kardar, Haian Fu, Sagar Lonial, Hanna Jean Khoury, Fadlo Khuri, and Jing Chen. (2007) 14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells. Blood 110(1), 360-369 PubMed Link 

Xia Liu, Zhixue Liu, Sung-Wuk Jang, Zhiyong Ma, Kazuya Shinmura, Sumin Kang, Shaozhong Dong, Norman E. Sharpless, Jing Chen, Kenji Fukasawa, and Keqiang Ye. (2007) Sumoylation of nucleospin/B23 regulates its subcellular localization, mediating cell proliferation and survival. Proc Natl Acad Sci U S A 104(23), 9679-9684 PubMed Link