Time-lapse imaging of cardiomyocyte cell division in culture. Video by Alex Payumo.
Catecholamines are released from sympathetic nerves to modulate cardiomyocyte contractile responses by activating adrenergic receptors. We are interested in understanding how adrenergic signaling influences cardiomyocyte cell-cycle activity and ploidy.
Cardiomyocyte metabolism shifts towards mitochondrial fatty acid oxidation during postnatal development. We are interested in understanding how mitochondrial homeostasis and function impact cardiomyocyte cell-cycle regulation.
Cardiomyocyte cell-cycle resolution is complex and conventional proliferative marker analyses can be misleading. We are employing a non-invasive long-term live-cell imaging approach to monitor cardiomyocyte behavior in 3D space.