About Us

Welcome to the laboratory of Saurabh Sinha at Georgia Tech.

Our research lies in the interdisciplinary field of bioinformatics, which provides the computational foundation for modern molecular biology as it rapidly develops into a quantitative science. Our current research centers on spatial omics, spatial multi-omics, and single-cell analysis, while also investigating the regulatory mechanisms underlying molecular and cellular behavior. Our goal is to understand how molecular states, cellular interactions, and tissue organization vary across biological conditions.

Our research spans multiple spatial scales, from the organization of RNA molecules within individual cells, to communication between neighboring cells, to coordinated transcriptomic and metabolic patterns across tissues. We develop rigorous and interpretable methods for comparative spatial analysis, subcellular RNA organization, cell–cell communication, spatial multi-omics integration, and the computational integration of microscopy with molecular measurements.

Our work draws on machine learning, causal inference, probabilistic modeling, spatial statistics, and optimization. Students in the lab work at the interface of bioinformatics, data science, and quantitative biology, developing new computational frameworks and applying them to real biological problems in close collaboration with experimental researchers.

We welcome students who are excited to formulate fundamental computational questions, develop broadly useful methods and open-source tools, and use emerging single-cell and spatial technologies to investigate biological systems in health and disease.

Principal Investigator: Saurabh Sinha.