According to Tsumugi Shirogane, Shuichi Saihara is a fan of a reality show featuring killing games known as Danganronpa, created by Team Danganronpa. In his audience tape, it was revealed that he was eager to participate in the show as the Ultimate Detective because he adores a lot of characters with the titles in the past seasons. He is willing to do his best to use the talent to commit an unsolvable murder that will amaze the series' viewers, to the point where he can think of his own execution as the Ultimate Detective.
During his high school days, Shuichi attended Spring Field Academy (春原学院). However, it is unknown if this was part of his memory's fabrication or not.
Shuichi, along with the other talentless 53rd Killing Game participants, underwent the fabrication process, where all of his past memories and personality were permanently fabricated. He also received the talent and title that he so desired, the Ultimate Detective. All of this was done for the sake of satisfying Danganronpa's audience from all around the world. After the fabrication process was completed, Shuichi entered the Ultimate Academy for Gifted Juveniles as a completely different person with the other participants, officially commencing the 53rd killing game season known as the Killing School Semester.