Publication

1. Nam, Y. R., Kang, M., Kim, M., Seok, M. J., Yang, Y., Han, Y. E., ... & Lee, S. H. (2024). Preparation of human astrocytes with potent therapeutic functions from human pluripotent stem cells using ventral midbrain patterning. Journal of Advanced Research.

2. Yang, Y., Seok, M. J., Kim, Y. E., Choi, Y., Song, J. J., Sulistio, Y. A., ... & Lee, S. H. (2022). Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology. Molecular Psychiatry, 1-16.

3. Yang, Y., Song, J. J., Choi, Y. R., Kim, S. H., Seok, M. J., Wulansari, N., ... & Lee, S. H. (2022). Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease. Proceedings of the National Academy of Sciences, 119(29), e2110746119.

4. Pieknell, K., Sulistio, Y. A., Wulansari, N., Darsono, W. H. W., Chang, M. Y., Ko, J. Y., ... & Lee, S. H. (2022). LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming. Cell Death & Differentiation, 29(3), 540-555.

5. Kim, S. W., Woo, H. J., Kim, E. H., Kim, H. S., Suh, H. N., Kim, S. H., ... & Lee, S. H. (2021). Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson’s disease: midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment. Progress in neurobiology, 204, 102086.

6. Wulansari, N., Darsono, W. H. W., Woo, H. J., Chang, M. Y., Kim, J., Bae, E. J., ... & Lee, S. H. (2021). Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson’s disease-linked DNAJC6 mutations. Science Advances, 7(8), eabb1540.

7. Wulansari, N., Sulistio, Y. A., Darsono, W. H. W., Kim, C. H., & Lee, S. H. (2021). LIF maintains mouse embryonic stem cells pluripotency by modulating TET1 and JMJD2 activity in a JAK2-dependent manner. Stem Cells, 39(6), 750-760.

8. Murti, H., Pieknell, K., Bachtiar, I., Sari, S. Y., Sulistio, Y. A., & Lee, S. H. (2021). Establishment human induced pluripotent stem cell line from idiopathic non-familial Parkinson’s disease patient using self-replicating RNA vector. Stem Cell Research, 50, 102137.

9.  Murti, H., Pieknell, K., Bachtiar, I., Sulistio, Y. A., & Lee, S. H. (2020). Generation of human induced pluripotent stem cell line from Alzheimer’s disease patient with PSEN2 N141I mutation using integration-free non-viral method. Stem Cell Research, 47, 101892.

10. Chang, M. Y., Oh, B., Choi, J. E., Sulistio, Y. A., Woo, H. J., Jo, A., ... & Park, J. (2019). LIN28A loss of function is associated with Parkinson's disease pathogenesis. The EMBO journal, 38(24). 

11. Rhee, Y. H., Puspita, L., Sulistio, Y. A., Kim, S. W., Vidyawan, V., Elvira, R., ... & Lee, S. H. (2019). Efficient Neural Differentiation of hPSCs by Extrinsic Signals Derived from Co-cultured Neural Stem or Precursor Cells. Molecular Therapy, 27(7), 1299-1312. 

12. Song JJ, Oh SM, Kwon OC, Wulnansari N, Lee HS, Chang MY, Lee E, Sun W, Lee SE, Chang S, An H, Lee CJ, Lee SH (2017).Correction of hostile brain environment by co-grafting astrocytes improves cell therapeutic outcomes in a Parkinson’s disease animal model. Journal of Clinical Investigation, 128(1):463-482.

13. Wulansari N, Kim EH, Sulistio YA, Song JJ, Rhee YH, Lee SH (2017). Vitamin C-induced Epigenetic Modifications in Donor NSCs Establish Midbrain-Specific Marker Expressions Critical for Cell-Based Therapy in Parkinson’s Disease. Stem cell Reports, 9(4): 1192-1206.

14. Kim T, Song JJ, Puspita L, Valiulahi P, Shim JW, Lee SH (2017). In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns. Exp. Mol. Med. 49(3):e300.

15. Rhee YH, Kim TH, Jo AY, Chang MY, Park CH, Kim SM, Song JJ, Oh SM, Yi SH, Kim HH,  You BH, Nam JW, and Lee SH (2016). Lin28a enhances the therapeutic potential of cultured neural stem cells in a Parkinson’s disease model. Brain, 139: 2722-2739..

16. Rhee YH, Yi SH, Kim JY, Chang MY, Jo AY, Kim J, Park CH, Cho JY, Choi YJ, Sun W, and Lee SH (2016). Neural stem cells secrete factors facilitating brain regeneration upon constitutive Raf-Erk activation. Scientific Reports, 6:32025.

17. Lim MS, Chang MY, Kim SM, Yi SH, Suh-Kim H, Jung SJ, Kim MJ, Kim JH,Lee YS, Lee SY, Kim DW, Park CH, Lee SH (2015). Generation of dopamine neurons from rodent fibroblasts through the expandable neural precursor cell stage. Journal of Biological Chemistry, 290(28), 17401-14.

18. Oh SM, Chang MY, Son JJ, Rhee YH, Joe EH, Lee HS, Yi SH, Lee SH (2015). Combined Nurr1 and Foxa2 roles in the therapy of Parkinson’s disease. EMBO molecular medicine, 7(5):510-25

19. He XB, Kim M, Kim SY, Yi SH, Rhee YH, Kim T, Lee EH, Park CH, Dixit S, Harrison FE, Lee SH (2015). Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through Tet1- and Jmjd3-dependent epigenetic control manner. Stem Cells, 33(4), 1320-32.

20. Chang MY, Rhee YH, Yi SH, L SJ, Kim RK, Kim H, Park CH, and Lee SH (2014) Doxycycline enhances survival and self-renewal of human pluripoteint stem cells. Stem cell Reports, 3. 353-364.

21. Yi SH, He XB, Rhee YH, Park CH, Takizawa T, Nakashima K, and Lee SH (2014) Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation. Development, 141(4), 761-72. 

22. Rhee YH, Choi M, Lee HS, Park CH, Kim SM, Yi SH, Oh SM, Cha HJ, Chang MY, Lee SH (2013). Insulin concentration is critical in culturing human neural stem cells and neurons. Cell Death & Disease. 4, e766, 1-10 

23. Park CH, Lim MS, Rhee YH, Yi SH, Kim BK, Shim JW, Kim YH, Jung SJ, and Lee SH (2012). In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1. Development, 139, 2447-51. 

24. He X, Yi SH, Rhee YH, Kim H, Han YM, Lee SH, Lee H, Park CH, Lee YS, Richardson E, Kim BW, Lee SH (2011). Prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications. Stem Cells, 29: 1861-1873. 

25. Rhee YH, Ko JY, Chang MY, Yi SH, Kim D, Kim CH, Shim JW, Jo AY, Kim BW, Lee H, Lee SH, Suh W, Park CH, Koh HC, Lee YS, Lanza R, Kim KS, Lee SH (2011). Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkionson disease. J. Clinical Investigation, 121(6), 2326-2335. 

26. Lee HS, Bae EJ, Yi SH, Shim JW, Jo AY, Kang JS, Yoon EH, Rhee YH, Park CH, Koh HC, Kim HJ, Choi HS, Han JW, Lee YS, Kim J, Li JY, Brundin P, and Lee SH (2010). Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. Stem Cells, 28: 501-512. 

27. Jo AY, Kim MY, Lee HS, Rhee YH, Lee JE, Baek KH, Park CH, Koh HC, Shin I, Lee YS, Lee SH (2009). Generation of Dopamine Neurons With Improved Cell Survival And Phenotype Maintenance Using A Degradation-Resistant Nurr1 Mutant. Stem Cells, 27(9): 2238-2246. 

28. Ko JY, Lee HS, Park CH, Koh HC, Lee YS, Lee SH (2009).Conditions for Tumor-free and Dopamine Neuron-enriched Grafts After Transplanting Human ES Cell-derived Neural Precursor Cells. Molecular Therapy, 17(10): 1762-1710. 

29. Bae EJ, Lee HS, Park CH, and Lee SH (2009). Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism. FEBS Letters, 583(9):1505-10 

30. Yi SH, Jo AY, Park CH, Koh HC, Park RH, Suh-Kim H, Shin I, Lee YS, Kim J, Lee SH (2008). Mash1 and Neurogenin2 enhance survival and differentiation of neural precursor cells after transplantation to rat brains via distinct modes of action. Molecular Therapy, 16(11), 1873-1882 

31. Park CH, Kang JS, Yoon EH Shim JW, Kim-Suh H and Lee SH (2008). Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro. FEBS Letters 582,537-542 

32. Jo AY, Park CH, Aizawa S, and Lee SH (2007). Contrasting and Brain Region-specific Roles of Neurogenin2 and Mash1 in GABAergic Neuron Differentiation In Vitro. Exp. Cell Res. 313, 4066-4081 

33. Ko JY, Park CH, Koh HC, Cho YH, Kyhm JH, Kim YS, Lee YS and Lee SH (2007). Human embryonic stem cell-derived neural precursors as a continuous, stable and on-demand source for human dopamine neurons. J. Neurochem., 103: 1417-1429 

34. Chang MY, Sun W, Ochiai W, Nakashima K, Kim SY, Park CH, Kang JS, Shim JW, Jo AY, Kang CS, Lee YS, Kim JS, Lee SH (2007). Bcl-XL/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells. Mol Cell Biol. 27(12): 4293-4305 

35. Shim JW, Park CH, Chang MY, Koh HC, Lee HS, Lee YS, Choi CY and and Lee SH (2007). Generation of Functional Dopamine Neurons from Neural Precursor Cells Isolated from the Subventricular Zone and White Matter of Adult Rat Brain using Nurr1 Overexpression. Stem cells, 25(5): 1252-62 

36. Park CH, Kang JS, Chang MY, Chung S, Koh HC, Zhu MH, Oh SB, Lee YS, Panagiotakos G, Tabar V, Studer L and Lee SH (2006). Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons. FASEB J. 20(14), 2553-5 

37. Park CH, Kang JS, Kim JS, Chung S, Koh JY, Yoon EH, Jo AY, Chang MY, Koh HC, Hwang S, Suh-Kim H,  Lee YS, Kim KS and Lee SH (2006) Differential actions of the proneural genes Mash1 and Neurogenins in Nurr1-induced dopamine neuron differentiation. Journal of Cell Science, 119, 2310-2320 

38. Ko JY, Lee JY, Park CH, and Lee SH (2005) Effect of cell-density on in vitro dopaminergic differentiation of mesencephalic precursor cells. NeuroReport, 16, 499-503 

39. Park CH, Minn YK, Lee JY, Choi DH, Chang MY, Shim JW, Ko JY, Koh HC, Kang MJ, Kang JS, Rhie DJ, Lee YS, Son H, Moon SY, Kim KS and Lee SH (2005)  In vitro and in vivo analyses of human embryonic stem  cell-derived dopamine neurons. J. Neurochem., 92, 1265-1276 

40. Chang MY, Park CH, Lee SY, Lee SH (2004) Properties of cortical precursor cells cultured long term are similar to those of precursors at later developmental stages. Developmental Brain Research 153, 89-96 

41. Chang MY, Park CH, Son H, Lee YS, Lee SH (2004) Developmental stage-dependent self-regulation of embryonic cortical precursor cell survival and differentiation by leukemia inhibitory factor. Cell Death and Differentiation. 11(9), 985-996 

42. Shim JW, Koh HC, Chang MY, Roh E, Choi CY, Oh YJ, Son H, Lee YS, Studer L, Lee SH (2004) Enhanced In Vitro Midbrain Dopamine Neuron Differentiation, Dopaminergic function, Neurite Outgrowth, and 1-Methyl-4-Phenylpyridium Resistance in Mouse Embryonic Stem Cell Overexpressing Bcl-XL. J. Neurosci. 24(4): 843-852 

43. Lee JY, Koh HC, Chang MY, Park CH, Lee YS, and Lee SH (2003) Erythropoietin and bone morphogenetic protein 7 mediate ascorbate-induced dopaminergic differentiation from embryonic mesencephalic precursors. Neuroreport 14(10): 1401-1404 

44. Lee JY, Chang MY, Park CH, Kim HY, Kim JH, Son H, Lee YS, and Lee SH (2003) Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes. J. Neurosci. Res. 73:156-165 

45. Chang MY, Park CH, Lee SH (2003) Embryonic cortical stem cells secrete diffusible factors to enhance their survival. Neuroreport 14(9): 1191-5 

46. Kim JY, Koh HC, Lee JY, Chang MY, Kim YC, Chung HY, Lee YS, Studer L, McKay RD, and Lee SH (2003) Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression. J. Neurochem. 85(6): 1443-54 

47. Chang MY, Son H, Lee YS, and Lee SH (2003) Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively. Mol. Cell. Neurosci. 23: 414-426 

48. Kim JS, Kim HY, Kim JH, Shin HK, Lee SH, Lee YS, Son H. (2002) Enhancement of rat hippocampal long-term potentiation by 17 beta-estradiol involves mitogen-activated protein kinase-dependent and -independent components. Neurosci. Lett. 332(1): 65-9 

49. Shin MH, Lee EG, Lee SH, Lee YS, Son H. (2002) Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type. Exp. Mol. Med. 34(6): 401-410 

50. Lee SH, Chang MY, Jeon DJ, Oh DY, Son H, Lee CH, Lee YS, Lee YS (2002) The functional domains of dopamine transporter for cocaine analog, CFT binding. Exp. Mol. Med. 34(1): 90-94 

51. Chang MY, Lee SH, Lee YS (2001) Protein kinase C-mediated functional regulation of dopamine transporter is not achieved by direct phosphorylation of the dopamine transporter protein. J. Neurochem., 77: 1 

52. Lee SH, Kang SS, Son H, and Lee YS (1998) The region of dopamine transporter encompassing the 3rd transmembrane domain in crucial for function. Biochemical Biophysical Research Communications. 246: 347-352 

53. Lee SH, Chang MY, Lee KH, Park BS, Lee YS, Chin HR, and Lee YS (2000) Importance of valine at position 152 for the substrate transport and CFT binding of dopamine transporter. Molecular pharmacology. 57: 12848 

54. Studer L, Csete M, Lee SH, Kabbani N, Walikonis J, Wold B, and McKay RD (2000) Enhanced proliferation, survival and dopaminergic differentiation of CNS precursors in lowered oxygen. J. Neurosci. 20(19): 7377 

55. Panchision DM, Pickel JM, Studer L, Lee SH, Turner PA, Hazel TG, McKay RDG (2001) Sequential actions of BMP receptors control neural precursor cell production and fate. Genes & Development 15: 2094-2110 

56. Kim YC, Shim JW, Oh YJ, Son H, Lee YS, Lee SH (2002) Co-transfection with cDNA encoding the Bcl family of anti-apoptotic proteins improves the efficiency of transfection in primary fetal neural stem cells. J. Neurosci. Methods, 117: 153-158 

57. Kim JH, Lee SH, McKay RD. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature, 418, 50-56, 2002 

58. Lee SH, Lumelsky N, Studer L, Auerbach JM, and  McKay RD (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotech. 18: 675-679