*corresponding author
Shiwaku H*
Autoantibodies and Inflammation in Schizophrenia.
Psychiatry Clin Neurosci. (2025)
Motokawa Y, Sugihara J, Tateishi T, Hosoya T, Yasuda S, Miyazaki Y, Takahashi H, Shiwaku H*
IBRO Neuroscience Reports; 19, 252-256 (2025)
Katayama S, Nayanar G, Suga T, Watanabe M, Takao C, Umezaki Y, Takahashi H, Toyofuku A, Shiwaku H*
Brain, Behavior, & Immunity - Health 47; 101036 (2025)
Toyoda S, Kikuchi M, Abe Y, Tashiro K, Handa T, Katayama S, Motokawa Y, Tanaka KF, Takahashi H, Shiwaku H*.
Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies.
EMBO reports (2025)
Tamura T, Takagi S, Hayakawa A, Oyama J, Fujino J, Shiwaku H, Takahashi H, Sugihara G.
Case report: Recurring and treatment-resistant depression in acquired hepatocerebral degeneration due to a congenital portosystemic shunt. Front Psychiatry. 23;15:1402695 (2024)
Toyoda S, Handa T, Yong H, Takahashi H, Shiwaku H*.
Matsuki H, Mandai S, Shiwaku H, Koide T, Takahashi N, Yanagi T, Inaba S, Ida S, Fujiki T, Mori Y, Ando F, Mori T, Susa K, Iimori S, Sohara E, Takahashi H, Uchida S.
Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging (Albany NY). 25;15(20):10972-10995. (2023)
Shiwaku H*, Katayama S, Gao M, Kondo K, Nakano Y, Motokawa Y, Toyoda S, Yoshida F, Hori H, Kubota T, Ishikawa K, Kunugi H, Ikegaya Y, Okazawa H, Takahashi H.
Kubota M, Takahata K, Matsuoka K, Sano Y, Yamamoto Y, Tagai K, Tarumi R, Suzuki H, Kurose S, Nakajima S, Shiwaku H, Seki C, Kawamura K, Zhang MR, Takahashi H, Takado Y, Higuchi M.
Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia. Schizophr Bull. 49:688-696. (2023)
Tamura T, Sugihara G, Okita K, Mukai Y, Matsuda H, Shiwaku H, Takagi S, Daisaki H, Tateishi U, Takahashi H.
Dopamine dysfunction in depression: application of texture analysis to dopamine transporter single-photon emission computed tomography imaging. Transl Psychiatry. 12:309. (2022)
Shiwaku H*, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H.
Katayama S, Kubota T, Takahashi H, Shiwaku H*.
Anti-rods/rings autoantibodies in a patient with pancreatic injury. Autoimmun Rev. 21(1):102922. (2022)
Jin M, Shiwaku H(co-first), Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H.
Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H.
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 15;4(7):e202101022. (2021)
Matsumoto Y, Fujino J, Shiwaku H, Miyajima M, Doi S, Hirai N, Jitoku D, Takagi S, Tamura T, Maruo T, Shidei Y, Kobayashi N, Ichihashi M, Noguchi S, Oohashi K, Takeuchi T, Sugihara G, Okada T, Fujiwara T, Takahashi H.
Factors affecting mental illness and social stress in hospital workers treating COVID-19: Paradoxical distress during pandemic era. J Psychiatr Res. 137:298-302. (2021)
Shiwaku H, Doi S, Miyajima M, Matsumoto Y, Fujino J, Hirai N, Jitoku D, Takagi S, Tamura T, Maruo T, Shidei Y, Kobayashi N, Ichihashi M, Noguchi S, Oohashi K, Takeuchi T, Sugihara G, Okada T, Fujiwara T, Takahashi H.
Novel brief screening scale, Tokyo Metropolitan Distress Scale for Pandemic (TMDP), for assessing mental and social stress of medical personnel in COVID-19 pandemic. Psychiatry Clin Neurosci. 75(1):24-25. (2021)
Shiwaku H*, Fujita M, Takahashi H.
Benzodiazepines Reduce Relapse and Recurrence Rates in Patients with Psychotic Depression. J Clin Med. 9(6):E1938. (2020)
Shiwaku H*, Nakano Y, Kato M, Takahashi H
Detection of autoantibodies against GABAARα1 in patients with schizophrenia. Schizophr Res. 216:543-546. (2020)
Tamura T, Shiwaku H, Jitoku D, Kurumaji A.
Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness. Prim Care Companion CNS Disord. 21(5):18l02403. (2019)
Shiwaku H, Nishikawa T
Paroxetine ameliorates whole-body allodynia. Eur J Clin Pharmacol., 74(7):979-980. (2018)
Shiwaku H, Kimura Y, Narushima K, Matsuda H, Nishikawa T.
Unilateral Atonia and Asymmetric Cholinergic Dysfunction in Ross Syndrome. Biological psychiatry 83(2):e31-e32 (2018).
Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H.
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. Nat Commun., 8(1):1864. (2017).
Shiwaku H, Umino A, Umino M, Nishikawa T.
Phencyclidine-induced dysregulation of primary cilia in the rodent brain. Brain Res. 1674:62-69. (2017).
Ito H, Shiwaku H (co-first), Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H.
In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry, 20:459-71. (2015).
Shiwaku H, Okazawa H.
Impaired DNA damage repair as a common feature of neurodegenerative diseases and psychiatric disorders. Curr Mol Med., 15:119-28. (2015).
Shiwaku H, Masaki H, Yasugi D, Narushima K.
A Case of a Depressed Patient With Major Titanium Cranial Base Reconstruction Successfully Treated by ECT. Am J Psychiatry., 172:1024-5. (2015)
Barclay SS, Tamura T, Ito H, Fujita K, Tagawa K, Shimamura T, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano S, Okazawa H.
Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Hum Mol Genet., 23:1345-1364.(2014)
Shiwaku H, Yagishita S, Eishi Y, Okazawa H.
Bergmann glia are reduced in spinocerebellar ataxia type 1. Neuroreport, 24:620-625. (2013).
Li C, Ito H, Fujita K, Shiwaku H, Qi Y, Tagawa K, Tamura T, Okazawa H.
Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells. PLoS One, 8(7):e68627. (2013).
Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nat Commun., 4:1816. (2013).
Nakamura Y, Tagawa K, Oka T, Sasabe T, Ito H, Shiwaku H, La Spada AR, Okazawa H.
Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network. Hum Mol Genet., 21:1099-1110. (2012).
Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, Tagawa K, Okazawa H.
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J., 29: 2446-2460. (2010)
Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H.
Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol., 189:425-443. (2010)
Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H.
Neural stem cells express Oct-3/4. Biochem Biophys Res Commun., 388:247-251. (2009)
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y.
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. PLoS One, 4:e4466. (2009)
Takahashi K, Yoshina S, Masashi M, Ito W, Inoue T, Shiwaku H, Arai H, Mitani S, Okazawa H.
Nematode homologue of PQBP1, a mental retardation causative gene, is involved in lipid metabolism. PLoS One, 4:e4104. (2009)