Shifting society’s dependence on petroleum-based fuels, chemicals, and materials to biomass derived products is important not only to reduce our carbon footprint but also to increase the robustness of our energy security and economic stability. There are emerging needs to address some of the societal and sustainability challenges in the food, energy, and water (FEW) nexus. The research areas we are working on under energy conversion and biosystems engineering are well suited to meet the FEW demands. Aligned with these research priorities, our overarching research goal is to understand and develop novel bioprocesses and models to produce biofuels, bioproducts, and renewable materials by exploring the interface between chemistry, engineering and system biology.