History of Issaquena County

Issaquena County is a county located in the state of Mississippi. It lies in the southernmost part of the Mississippi Delta Region with Mayersville as its county seat. The county was created from Washington County in 1844. The name of the county is derived from a Native American name meaning “Deer River.” At the time, the Governor of Mississippi was Albert Brown; John Tyler was the United States President.

Current Communities are:

Incorporated towns:

  • Mayersville

Unincorporated communities:

  • Fitler
  • Grace
  • Tallulah
  • Valley Park