CHE0504

CHE0504 - Analytical Chemistry

Error analysis: Errors - Determinant, constant and indeterminate. Accuracy and precision- Distribution of random errors. Average deviation and standard deviation, variance and confidence limits.

Significant figures and computation rules. Least squares method of analysis.

Methods of sampling: sample size, techniques of sampling of gases, fluids, solids, and particulates.

Chromatographic methods: General principles - classification of chromatographic methods - nature of partition forces. Chromatographic behavior of solutes- column efficiency and resolution.

Gas Chromatography: detector, optimization of experimental conditions. Ion-exchange chromatography, thin layer chromatography, coating of materials, preparative TLC.

Solvents used and methods of detection - Column chromatography: Adsorption and partition methods. Nature of column materials-preparation of the column.

Thermo Gravimetric Analysis and Differential Scanning Calorimetry: Effect of heat on materials, Chemical decomposition and T, G curves, Analysis of T, G. curve to show nature of decomposition reactions, the product and qualities of compounds expelled, applications, instrumentation.

DSC- theory, instrumentation and applications - thermometric titrations and applications.

AAS and ICP: Atomic Absorption Spectroscopy- Introduction, Principle, differences between AAS and FES - Advantages of AAS over FES, advantages and disadvantages of AAS. Instrumentation - single and double beam AAS, detection limit and sensitivity, Interferences - applications.

Inductively coupled Plasma Spectroscopy - Nebulization Torch, Plasma, Instrumentation, Interferences, Applications.

Flame photometry: Principle – instrumentation-applications

Electroanalytical techniques: Cyclic voltammetry: Principles, instrumentation, and analytical applications - Differential pulse voltametry and Square wave voltametry.

Polarography: Introduction, Instrumentation, Ilkovic equation and its verification. Determination of half-wave potential, qualitative and quantitative applications.

Amperometry: Basic principles, instrumentation, nature of titration curves, and analytical applications.

Prescribed Books

1. H. H. Willard, L. L. Merritt, and J. A. Dean, Instrumental Methods of analysis, CBS Publishers & Distributors, Shahdara, Delhi, 6^th edition, 1986.

2. D. Skoog and D.West , Principles of Instrumental Analysis, Cengage Learning; 6^th edition, 2006.

Reference Books

1. Gary D. Christian, Analytical Chemistry, John Wiley & Sons, 6^th edition, 2007.

2. J. M. Bobbitt, Roy Gritter, Introduction to chromatography, Holden Day; 2^nd edition, 1985.

3. Gurdeep R. Chatwal, Sham K. Anand, Instrumental Methods of Analysis, Himalaya Pub., 1979.

4. G. Svehla: Vogel’s qualitative inorganic analysis, 7^th Edition, Prentice Hall, 1996.

5. Howard A. Strobel, William R. Heineman, Chemical Instrumentation: A Systematic approach, Wiley-Interscience; 3 edition, 1989.

6. W.E.Morf, The principles of ion-selective electrodes and membrane transport, Elsevier Science Ltd, 1981.

7. Atkins, P. W.; Paula, J.; Physical Chemistry, Oxford Publications, 8^th edition, 2009.

8. I.M. Kolthoff , Treatise on Analytical Chemistry, Wiley Interscience, Vol I to VII .