主な研究業績

Tanabe M, Kunisawa K, Saito I, Kosuge A, Tezuka H, Kawai T, Kon Y, Yoshidomi K, Kagami A, Hasegawa M, Kubota H, Ojika H, Fujii T, Tochio T, Hirooka Y, Saito K, Nabeshima T, Mouri A. 

Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine. 

Mol Psychiatry. 2024 Nov 29. doi: 10.1038/s41380-024-02826-9. Epub ahead of print. PMID: 39613916.

Hasegawa M, Niijima M, Kunisawa K, Teshigawara T, Kubota H, Fujigaki S, Fujigaki H, Yamamoto Y, Kim HC, Saito K, Nabeshima T, Mouri A. 

Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta. 

Biochem Biophys Res Commun. 2024 Dec 10;737:150922. doi: 10.1016/j.bbrc.2024.150922. Epub 2024

Oct 28. PMID: 39486137.

Yamamoto Y, Goto N, Kambara K, Fujigaki S, Fujigaki H, Takemura M, Nabeshima T, Tomita A, Saito K.

Usefulness of the 3-hydroxykynurenine/kynurenic acid ratio as a diagnostic biomarker for diffuse larger B-cell lymphoma. 

Ann Clin Biochem. 2025 Mar;62(2):109-117. doi: 10.1177/00045632241297873. Epub 2024 Nov 11. PMID:

39439179.

Kurahashi H, Kunisawa K, Tanaka KF, Kubota H, Hasegawa M, Miyachi M, Moriya Y, Hasegawa Y, Nagai T, Saito K, Nabeshima T, Mouri A. 

Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through

hypo-serotonergic 5-HT_1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid. 

Neuropsychopharmacology. 2025 Apr;50(5):739-750. doi: 10.1038/s41386-024-02004-z. Epub 2024 Oct 11. PMID: 39394255; PMCID: PMC11914464.

Kubota H, Kunisawa K, Hasegawa M, Kurahashi H, Kagotani K, Fujimoto Y, Hayashi A, Sono R, Tsuji T, Saito K, Nabeshima T, Mouri A. 

Soy lysolecithin prevents hypertension and cognitive impairment induced in mice by high salt intake by inhibiting intestinal inflammation. 

Neurochem Int. 2024 Nov;180:105858. doi: 10.1016/j.neuint.2024.105858. Epub 2024 Sep 12. PMID: 39271020.

Ishihara Y, Naruse H, Fujigaki H, Murakami R, Ando T, Sakurai K, Uehara K, Shimomae K, Sakaguchi E, Hattori H, Sarai M, Ishii J, Fujii R, Ito H, Saito K, Izawa H. 

Humoral and Cellular Response Induced by Primary Series and Booster Doses of mRNA Coronavirus Disease 2019 Vaccine in Patients with Cardiovascular Disease: A Longitudinal Study. 

Vaccines (Basel). 2024 Jul 17;12(7):786. doi: 10.3390/vaccines12070786. PMID: 39066424; PMCID: PMC11281625.

Sakaguchi E, Naruse H, Ishihara Y, Hattori H, Yamada A, Kawai H, Muramatsu T, Kitagawa F, Takahashi H, Ishii J, Sarai M, Yanase M, Ozaki Y, Saito K, Izawa H.

Efficacy of CHA₂DS₂-VASc scores in predicting chronic kidney disease risk in patients treated in cardiac intensive care units.

Heliyon. 2024 Jun 5;10(13):e32452. doi: 10.1016/j.heliyon.2024.e32452. PMID: 39044981; PMCID: PMC11263721.

Imaeda M, Tanaka S, Oya-Ito T, Uematsu M, Fujigaki H, Saito K, Ando M, Ozaki N. 

Secondary carnitine deficiency during refeeding in severely malnourished patients with eating disorders: a retrospective cohort study. 

J Eat Disord. 2024 Jul 9;12(1):97. doi: 10.1186/s40337-024-01054-4. PMID: 38982532; PMCID: PMC11232142.

Mizutani A, Nishikawa T, Fujigaki H, Yamamoto Y, Saito K, Hatayama S, Fukuwatari T. 

Chronic Endurance Exercise Impairs Niacin Nutritional Status in Mice. 

J Nutr Sci Vitaminol (Tokyo). 2024;70(3):185-192. doi: 10.3177/jnsv.70.185. PMID: 38945883.

Kosuge A, Kunisawa K, Iida T, Wulaer B, Kawai T, Tanabe M, Saito K, Nabeshima T, Mouri A. 

Chronic social defeat stress induces the down-regulation of the Nedd4L-GLT-1 ubiquitination pathway in the prefrontal cortex of mice. 

J Neurochem. 2024 Sep;168(9):2479-2494. doi: 10.1111/jnc.16100. Epub 2024 Mar 18. PMID: 38497582.

Mizutani A, Goto C, Fujigaki H, Yamamoto Y, Saito K, Hatayama S, Fukuwatari T. 

Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice. 

J Nutr Sci Vitaminol (Tokyo). 2024;70(1):1-8. doi: 10.3177/jnsv.70.1. PMID: 38417847.

Hayashi R, Takami Y, Fujigaki H, Amano K, Akita K, Yamana K, Maekawa A, Saito K, Takagi Y. 

Optimal timing of SARS-CoV-2 vaccination prior to cardiovascular surgery under cardiopulmonary bypass. Int J Artif Organs. 2024 Mar;47(3):147-154. doi: 10.1177/03913988241234475. Epub 2024 Feb 28. PMID: 38415725.

Morishita T, Takemura M, Hayashi M, Saito K, Yamamoto Y, Tsurumi H, Matsunami H. 

Cohort profile: rationale and design of the Resource Center for Health Science (RECHS) project - a study of health hazards and medical cost burden among the Japanese population. 

BMJ Open. 2024 Feb 1;14(2):e077720. doi: 10.1136/bmjopen-2023-077720. PMID: 38307527; PMCID: PMC10836369.

Sakaguchi E, Naruse H, Ishihara Y, Hattori H, Yamada A, Kawai H, Muramatsu T, Tsuboi Y, Fujii R, Suzuki K, Ishii J, Saito K, Sarai M, Yanase M, Ozaki Y, Izawa H. 

Assessment of the renal angina index in patients hospitalized in a cardiac intensive care unit. 

Sci Rep. 2024 Jan 2;14(1):75. doi: 10.1038/s41598-023-51086-0. PMID: 38168588; PMCID: PMC10762003.

Ishikawa M, Yamamoto Y, Wulaer B, Kunisawa K, Fujigaki H, Ando T, Kimura H, Kushima I, Arioka Y, Torii Y, Mouri A, Ozaki N, Nabeshima T, Saito K.

Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. 

FEBS J. 2024 Mar;291(5):945-964. doi: 10.1111/febs.17019. Epub 2024 Jan 2. PMID: 38037233.

Mizutani A, Sato M, Fujigaki H, Yamamoto Y, Saito K, Hatayama S, Fukuwatari T. 

Establishment of Model Mice to Evaluate Low Niacin Nutritional Status. 

J Nutr Sci Vitaminol (Tokyo). 2023;69(5):305-313. doi: 10.3177/jnsv.69.305. PMID: 37940571.

Menjo H, Hasegawa M, Fujigaki H, Ishihara T, Minatoguchi S, Koide S, Hayashi H, Saito M, Takahashi K, Ito H, Yuzawa Y, Saito K, Tsuboi N. 

Comparison of the Serial Humoral Immune Response according to the Immunosuppressive Treatment

after SARS-CoV-2 mRNA Vaccination. 

Intern Med. 2023 Dec 1;62(23):3445-3454. doi: 10.2169/internalmedicine.1949-23. Epub 2023 Sep 29. PMID: 37779074; PMCID: PMC10749798.

Takagi E, Terakura S, Fujigaki H, Okamoto A, Miyao K, Sawa M, Morishita T, Goto T, Ozawa Y, Nishida T, Fukushima N, Ozeki K, Hanajiri R, Saito K, Murata M, Tomita A, Kiyoi H. 

Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts. 

Int J Hematol. 2023 Oct;118(4):462-471. doi: 10.1007/s12185-023-03648-1. Epub 2023 Aug 10. PMID:

37561340.

Sukeda N, Fujigaki H, Ando T, Ando H, Yamamoto Y, Saito K. Identification of 2',4',6'-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity. 

Mol Cancer Ther. 2023 Jun 7:OF1-OF9. doi: 10.1158/1535-7163.MCT-22-0564. Epub ahead of print. PMID:

37294883.

Hidekazu I, Nagasawa H, Yamamoto Y, Doi H, Saito M, Ishihara Y, Fujita T, Ishida M, Kato Y, Kikuchi R, Matsunami H, Takemura M, Ito H, Saito K. 

Dataset dependency of low-density lipoprotein-cholesterol estimation by machine learning. 

Ann Clin Biochem. 2023 Nov;60(6):396-405. doi: 10.1177/00045632231180408. Epub 2023 Jun 5. PMID: 37218090.

Morita N, Hoshi M, Tezuka H, Ando T, Yoshida S, Sato F, Yokoi H, Ito H, Saito K. 

CD8+ Regulatory T Cells Induced by Lipopolysaccharide Improve Mouse Endotoxin Shock. 

Immunohorizons. 2023 May 1;7(5):353-363. doi: 10.4049/immunohorizons.2200074. PMID: 37212786; PMCID: PMC10579971.

Kubota H, Kunisawa K, Wulaer B, Hasegawa M, Kurahashi H, Sakata T, Tezuka H, Kugita M, Nagao S, Nagai T, Furuyashiki T, Narumiya S, Saito K, Nabeshima T, Mouri A. 

High salt induces cognitive impairment via the interaction of the angiotensin II-AT₁ and prostaglandin E2-EP₁ systems. 

Br J Pharmacol. 2023 Sep;180(18):2393-2411. doi: 10.1111/bph.16093. Epub 2023 May 17. PMID: 37076133.

Kondo T, Teramoto A, Watanabe E, Sobue Y, Izawa H, Saito K, Fujita H. 

Prediction of Short-Term Mortality of Cardiac Care Unit Patients Using Image-Transformed ECG Waveforms.

IEEE J Transl Eng Health Med. 2023 Feb 28;11:191-198. doi: 10.1109/JTEHM.2023.3250352. PMID: 36994109; PMCID: PMC10042295.

Mouri A, Hasegawa M, Kunisawa K, Saito K, Nabeshima T. 

[Diagnoses and new therapeutic strategy focused on physiological alteration of tryptophan metabolism].

Nihon Yakurigaku Zasshi. 2023 May 1;158(3):233-237. Japanese. doi: 10.1254/fpj.22139. Epub 2023 Mar 29. PMID: 36990795.

Ando T, Hoshi M, Tezuka H, Ito H, Nakamoto K, Yamamoto Y, Saito K. Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice. 

Mol Med Rep. 2023 Feb;27(2):24. doi: 10.3892/mmr.2022.12911. Epub 2022 Dec 9. PMID: 36484383; PMCID: PMC9813552.

Sakaguchi E, Yamada A, Naruse H, Hattori H, Nishimura H, Kawai H, Muramatsu T, Ishii J, Hata T, Saito K, Izawa H. 

Long-term prognostic value of changes in left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction. 

Heart Vessels. 2023 May;38(5):645-652. doi: 10.1007/s00380-022-02211-y. Epub 2022 Dec 1. PMID: 36450933.

Teramoto A, Tsukamoto T, Michiba A, Kiriyama Y, Sakurai E, Imaizumi K, Saito K, Fujita H. 

Automated Classification of Idiopathic Pulmonary Fibrosis in Pathological Images Using Convolutional Neural Network and Generative Adversarial Networks. 

Diagnostics (Basel). 2022 Dec 16;12(12):3195. doi: 10.3390/diagnostics12123195. PMID: 36553202; PMCID: PMC9777207.

Sakai A, Morishita T, Suzumura K, Hanatate F, Yoshikawa T, Sasaki N, Lee S, Fujita K, Hara T, Araki H, Tagami A, Murayama M, Yamada R, Iwata A, Sobajima T, Kasahara Y, Matsuzawa Y, Takemura M, Yamamoto Y, Fujigaki H, Saito K, Tsurumi H, Matsunami H. 

The Trajectory of the COVID-19 Vaccine Antibody Titers Over Time and the Association of Mycophenolate Mofetil in Solid Organ Transplant Recipients. 

Transplant Proc. 2022 Dec;54(10):2638-2645. doi: 10.1016/j.transproceed.2022.10.023. Epub 2022 Oct 7. PMID: 36372567; PMCID: PMC9537258.

Kubota H, Kunisawa K, Niijima M, Hirakawa M, Mori Y, Hasegawa M, Fujigaki S, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. 

Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by

phencyclidine. 

Biochem Biophys Res Commun. 2022 Nov 12;629:142-151. doi: 10.1016/j.bbrc.2022.09.003. Epub 2022 Sep 11. PMID: 36116377.

Teramoto A, Shibata T, Yamada H, Hirooka Y, Saito K, Fujita H. Detection and Characterization of Gastric Cancer Using Cascade Deep Learning Model in Endoscopic Images. 

Diagnostics (Basel). 2022 Aug 18;12(8):1996. doi: 10.3390/diagnostics12081996. PMID: 36010346; PMCID: PMC9406996.

Toda R, Teramoto A, Kondo M, Imaizumi K, Saito K, Fujita H. 

Lung cancer CT image generation from a free-form sketch using style-based pix2pix for data augmentation. Sci Rep. 2022 Jul 27;12(1):12867. doi: 10.1038/s41598-022-16861-5. PMID: 35896575; PMCID: PMC9329467.

Kunisawa K, Shan J, Lu Q, Yang Y, Kosuge A, Kurahashi H, Saito K, Zou L, Nabeshima T, Mouri A. 

Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice. 

Neurochem Res. 2022 Sep;47(9):2880-2889. doi: 10.1007/s11064-022-03692-z. Epub 2022 Jul 24. PMID:

35871434.

Yang Y, Mouri A, Lu Q, Kunisawa K, Kubota H, Hasegawa M, Hirakawa M, Mori Y, Libo Z, Saito K, Nabeshima T.

Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic

Corticosterone Exposure in Mice. 

Neurochem Res. 2022 Sep;47(9):2865-2879. doi: 10.1007/s11064-022-03694-x. Epub 2022 Jul 24. PMID: 35871433.

Yamazaki K, Hoshi M, Tezuka H, Morita N, Hirayama M, Sato F, Yoshida S, Saito K. 

D‑allose enhances the efficacy of hydroxychloroquine against Lewis lung carcinoma cell growth by inducing autophagy. 

Oncol Rep. 2022 Jun;47(6):117. doi: 10.3892/or.2022.8328. Epub 2022 May 11. PMID: 35543153; PMCID: PMC9115634.

Hayashi R, Takami Y, Fujigaki H, Amano K, Sakurai Y, Akita K, Yamana K, Maekawa A, Saito K, Takagi Y. 

Effects of cardiopulmonary bypass on immunoglobulin G antibody titres after SARS-CoV2 vaccination.

Interact Cardiovasc Thorac Surg. 2022 Aug 3;35(3):ivac123. doi: 10.1093/icvts/ivac123. PMID: 35521991; PMCID: PMC9383986.

Yoshinaga M, Muramatsu T, Fujigaki H, Saito K, Izawa H. 

Antibody testing for COVID-19 in patients with acute coronary syndrome in Aichi Prefecture. 

Fujita Med J. 2022 May;8(2):65-66. doi: 10.20407/fmj.2020-032. Epub 2021 Aug 20. PMID: 35520295; PMCID: PMC9069268.

Ishida H, Yamamoto Y, Saito M, Ishihara Y, Fujita T, Ishida M, Kato Y, Nohisa Y, Matsunami H, Takemura M, Hata T, Ito H, Saito K. 

Validation of the Martin method to estimate low-density lipoprotein cholesterol concentrations in

Japanese populations and a modified method for laboratory information system application. 

Ann Clin Biochem. 2022 Sep;59(5):316-323. doi: 10.1177/00045632221098870. Epub 2022 May 7. PMID: 35443810.

Fujigaki H, Yamamoto Y, Koseki T, Banno S, Ando T, Ito H, Fujita T, Naruse H, Hata T, Moriyama S, Takahashi Y, Suzuki T, Murakami T, Yoshida Y, Yagura Y, Oyamada T, Takemura M, Kondo M, Iwata M, Saito K. 

Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2. 

Microbiol Spectr. 2022 Feb 23;10(1):e0118121. doi: 10.1128/spectrum.01181-21. Epub 2022 Jan 19. PMID:

35044205; PMCID: PMC8768797.

Okamoto A, Fujigaki H, Iriyama C, Goto N, Yamamoto H, Mihara K, Inaguma Y, Miura Y, Furukawa K, Yamamoto Y, Akatsuka Y, Kasahara S, Miyao K, Tokuda M, Sato S, Mizutani Y, Osawa M, Hattori K, Iba S, Kajiya R, Okamoto M, Saito K, Tomita A. 

CD19-positive lymphocyte count is critical for acquisition of anti-SARS-CoV-2 IgG after vaccination in B-cell lymphoma. 

Blood Adv. 2022 Jun 14;6(11):3230-3233. doi: 10.1182/bloodadvances.2021006302. PMID: 35026843;

PMCID: PMC8759802.

Jozuka R, Kimura H, Uematsu T, Fujigaki H, Yamamoto Y, Kobayashi M, Kawabata K, Koike H, Inada T, Saito K, Katsuno M, Ozaki N. 

Severe and long-lasting neuropsychiatric symptoms after mild respiratory symptoms caused by COVID-19: A

case report. 

Neuropsychopharmacol Rep. 2022 Mar;42(1):114-119. doi: 10.1002/npr2.12222. Epub 2021 Dec 10. PMID: 34889531; PMCID: PMC8919122.

Naruse H, Ito H, Izawa H, Sarai M, Ishii J, Sakaguchi E, Murakami R, Ando T, Fujigaki H, Saito K.

Immunogenicity of BNT162b2 mRNA COVID-19 Vaccine in Patients with Cardiovascular Disease. 

J Clin Med. 2021 Nov 24;10(23):5498. doi: 10.3390/jcm10235498. PMID: 34884205; PMCID: PMC8658500.

Teramoto A, Kiriyama Y, Tsukamoto T, Sakurai E, Michiba A, Imaizumi K, Saito K, Fujita H. 

Weakly supervised learning for classification of lung cytological images using attention-based multiple instance learning. 

Sci Rep. 2021 Oct 13;11(1):20317. doi: 10.1038/s41598-021-99246-4. PMID: 34645863; PMCID:

PMC8514584.

Doi Y, Teramoto A, Yamada A, Kobayashi M, Saito K, Fujita H. 

Estimating subjective evaluation of low-contrast resolution using convolutional neural networks. 

Phys Eng Sci Med. 2021 Dec;44(4):1285-1296. doi: 10.1007/s13246-021-01062-7. Epub 2021 Oct 11. PMID: 34633630.

Morita N, Hoshi M, Hara T, Ninomiya S, Enoki T, Yoneda M, Tsurumi H, Saito K. 

Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity. 

Oncol Lett. 2021 Nov;22(5):790. doi: 10.3892/ol.2021.13051. Epub 2021 Sep 17. PMID: 34584567; PMCID: PMC8461759.

Blachier F, Blais A, Elango R, Saito K, Shimomura Y, Kadowaki M, Matsumoto H. 

Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies. 

Amino Acids. 2021 Sep;53(9):1313-1328. doi: 10.1007/s00726-021-03054-z. Epub 2021 Aug 2. PMID: 34338884; PMCID:

PMC8416832.

Ishida H, Takemura M, Suetsugu A, Naiki T, Tanaka T, Eiichi T, Serrero G, Matsunami H, Yamamoto Y, Saito K.

Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents. 

Ann Clin Biochem. 2021 Nov;58(6):605-613. doi: 10.1177/00045632211036723. Epub 2021 Aug 11. PMID: 34284614.

Hoshi M, Kubo H, Ando T, Tashita C, Nakamoto K, Yamamoto Y, Tezuka H, Saito K. 

3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice. 

Immunohorizons. 2021 Jun 28;5(6):523-534. doi: 10.4049/immunohorizons.2100028. PMID: 34183381.

Kosuge A, Kunisawa K, Arai S, Sugawara Y, Shinohara K, Iida T, Wulaer B, Kawai T, Fujigaki H, Yamamoto Y, Saito K, Nabeshima T, Mouri A. 

Heat-sterilized Bifidobacterium breve prevents depression-like behavior and interleukin-1β expression in mice exposed to chronic social defeat stress. 

Brain Behav Immun. 2021 Aug;96:200-211. doi: 10.1016/j.bbi.2021.05.028. Epub 2021 May 29. PMID:

34062230.

Hayakawa T, Teramoto A, Kiriyama Y, Tsukamoto T, Yamada A, Saito K, Fujita H. 

Development of Pathological Diagnosis Support System Using Micro-computed Tomography. 

Acta Histochem Cytochem. 2021 Apr 28;54(2):49-56. doi: 10.1267/ahc.20-00033. Epub 2021 Apr 22. PMID: 34012176; PMCID: PMC8116619.

Fujigaki H, Inaba M, Osawa M, Moriyama S, Takahashi Y, Suzuki T, Yamase K, Yoshida Y, Yagura Y, Oyamada T, Takemura M, Doi Y, Saito K. 

Comparative Analysis of Antigen-Specific Anti-SARS-CoV-2 Antibody Isotypes in COVID-19 Patients. 

J Immunol. 2021 May 15;206(10):2393-2401. doi: 10.4049/jimmunol.2001369. Epub 2021 May 3. PMID: 33941657.

Teramoto A, Yamada A, Tsukamoto T, Kiriyama Y, Sakurai E, Shiogama K, Michiba A, Imaizumi K, Saito K, Fujita H. 

Mutual stain conversion between Giemsa and Papanicolaou in cytological images using cycle generative adversarial network. 

Heliyon. 2021 Feb 24;7(2):e06331. doi: 10.1016/j.heliyon.2021.e06331. PMID: 33718644; PMCID: PMC7921513.

Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T. 

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice. 

Mol Brain. 2021 Feb 28;14(1):43. doi: 10.1186/s13041-021-00760-3. PMID: 33640003; PMCID: PMC7916264.

Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H, Yamamoto Y, Nabeshima T, Saito K. 

Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid. 

Behav Brain Res. 2021 May 7;405:113191. doi: 10.1016/j.bbr.2021.113191. Epub 2021 Feb 16. PMID: 33607168.

Yabe K, Yamamoto Y, Takemura M, Hara T, Tsurumi H, Serrero G, Nabeshima T, Saito K. 

Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells.

Heliyon. 2021 Jan 8;7(1):e05849. doi: 10.1016/j.heliyon.2020.e05849. PMID: 33490663; PMCID: PMC7809376.

Toda R, Teramoto A, Tsujimoto M, Toyama H, Imaizumi K, Saito K, Fujita H. 

Synthetic CT image generation of shape-controlled lung cancer using semi- conditional InfoGAN and its applicability for type classification. 

Int J Comput Assist Radiol Surg. 2021 Feb;16(2):241-251. doi: 10.1007/s11548-021-02308-1. Epub 2021 Jan 11. PMID: 33428062.

Sumitomo M, Takahara K, Zennami K, Nagakawa T, Maeda Y, Shiogama K, Yamamoto Y, Muto Y, Nukaya T, Takenaka M, Fukaya K, Ichino M, Sasaki H, Saito K, Shiroki R. 

Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. Cancer Sci. 2021 Mar;112(3):1038-1047. doi: 10.1111/cas.14797. Epub 2021 Jan 25. PMID: 33410234; PMCID: PMC7935775.

Suento WJ, Kunisawa K, Wulaer B, Kosuge A, Iida T, Fujigaki S, Fujigaki H, Yamamoto Y, Tanra AJ, Saito K, Mouri A, Nabeshima T. 

Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through

inhibition of indoleamine 2,3-dioxygenase 1 expression in mice. 

J Neurochem. 2021 Jun;157(6):1963-1978. doi: 10.1111/jnc.15222. Epub 2020 Nov 13. PMID: 33095942.