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WP 1 - Technological empowering of the Biological Imaging services
WP 1 - Technological empowering of the Biological Imaging services
WP Leader: IEOS-CNR
Operative Units (OU):
IEOS-CNR Naples
IN-CNR Padua
University of Genoa - Laboratory for Advanced Microscopy Bioimaging Spectroscopy
University of Florence - Laboratorio Europeo di Spettroscopie Non Lineari (UNIFI-LENS)
Activities
Empowering the imaging technologies at the Advanced light microscopy (ALM) node of EuroBioimaging (EUBI) - Italy. The ALM node consists of 5 centers of which four located in Napoli, Padova, Genova and Firenze are participating in this call and propose to potentiate the imaging technologies they specialize in. The list of technologies which will be potentiated in each of the 4 centers are as follows:
Napoli: Electron microscopy (EM) specifically Volume EM and array tomography, label-free imaging based on Raman microscopy and Imaging Mass Spectrometry (IMS)
Padova: In vivo functional imaging, STED Super-resolution microscopy and high throughput microscopy
Genova: Super-resolution microscopy and label-free imaging
Firenze: hyperspectral microscopy, high-speed spinning disk confocal microscopy, third order Sum Frequency Generation (TSFG) and vibrationally-resonant SFG (VR-SFG) microscopy and photonic biosensors
WP 2 - Technological empowering of the Medical Imaging services
WP 2 - Technological empowering of the Medical Imaging services
WP Leader: University of Turin - Department of Molecular Biotechnology and Health Sciences
Operative Units (OU):
University of Turin - Department of Molecular Biotechnology and Health Sciences
IBFM-CNR Segrate (Mi)
University of Pisa
IBB-CNR Naples
Activities
The technological empowering of the medical imaging represents the most relevant action in the project with the aim of substantially improving the performance of the instrumentation for preclinical and clinical research within the five EUBI-ITA facilities offering medical imaging services. The main interventions planned are:
the acquisition of a 3 T MRI scanner for preclinical and clinical research, with excellent spatial resolution and sensitivity, and an overall performance not achievable by the scanners currently available in the network. This scanner is very suitable for neuroimaging studies, e.g., for sampling neural activity at the level of different cortical layers, the characterization of functional microcircuitry, offering connectomics studies, thus considerably potentiating services in this very important research field.
The acquisition of a DNP polarizer for hyperpolarized metabolic imaging technology that has opened the unique possibility for non- invasively studying biochemical changes in disease processes by improving the sensitivity of MRI more than 20,000-fold. This system could be integrated with a PET-MRI scanner, thus offering to the national scientific community, for the first time in Italy, the opportunity to have open access to such technology, either for preclinical or clinical applications.
A general, but relevant, strengthening of nuclear imaging technologies, not only directed to highly performant scanners (PET/CT and SPECT/CT), but also on radiotracers production and development through investments specifically dedicated for empowering the radiopharmaceutical activity in several network facilities
A strong implementation of the multimodal imaging capacity of the network through both the acquisition of new state-of-the-art multimodal scanners (e.g., a tetra/penta-modal PET/SPECT/CT/NIRF(BLI) preclinical scanner, unique in Italy, or a SPECT/CT with a 3D autoradiography module) and the upgrade of instruments already at the facilities with new technologies (e.g. the integration of a preclinical PET/SPECT/CT with NIRF/BLI modalities, the implementation of a PET/MRI scanner with EEG technology, or the acquisition of a MRI coil integrated with an ultrasound transducer) to fully exploit the advantages of multimodality and provide the users a wide offer with some hybrid technologies not yet available in Italy.
WP 3 - Implementing integrated services and networking with external infrastructures
WP 3 - Implementing integrated services and networking with external infrastructures
WP Leader: IBFM-CNR Segrate (Mi) - Institute of bioimaging and molecular physiology
Operative Units (OU):
IBFM-CNR Segrate (Mi)
University of Turin - Department of Molecular Biotechnology and Health Sciences
University of Pisa
IFC-CNR Padua
IBB-CNR Naples
IEOS-CNR Naples
Activities
Integration of services and networking with other infrastructures operating in life sciences (LS) landscape have a key role in the strengthening process of any research infrastructure.
WP3 is aimed at achieving two main objectives:
activating synergy between the two complementary communities, i.e. biological and medical imaging scientists, that participate to the life of Eu-BI-ITA network;
finding fruitful connections with other national research networks with expertise and interests in the life sciences to get mutual benefits. The design of tailored use cases where biological (in vitro) and medical (in vivo, preclinical and clinical) imaging can fully exploit their complementarity is likely the most suitable tool to achieve the first objective, and two activities in this WP will be focused on the design of two representative examples of integrated bio-medical imaging services that could be offered to the users.
WP 4 - Empowering of training activity and dissemination
WP 4 - Empowering of training activity and dissemination
WP Leader: University of Genoa - Laboratory for Advanced Microscopy Bioimaging Spectroscopy
Operative Units (OU):
IEOS-CNR Naples
IBFM-CNR Segrate (Mi)
IFC-CNR Padua
IBB-CNR Naples
IN-CNR Pisa
University of Turin - Department of Molecular Biotechnology and Health Sciences
University of Pisa
University of Florence
University of Genoa
Activities
The infrastructure offers state-of-the-art light and electron microscopy, medical imaging, and correlative technologies, including methods not yet commercially available. While rapid technological advancements have accelerated scientific discoveries, access to the latest imaging technologies remains limited due to cost and complexity. The Italian infrastructure provides integrated access to multiple technologies and offers expert guidance and training to scientists, enabling them to utilize these methods effectively. This training facilitates independent application of techniques and protocol development, maximizing the use of available resources in institutes across Italy.
WP 5 - Project Management
WP 5 - Project Management
WP Leader: IEOS-CNR Naples
Operative Units (OU):
IEOS-CNR Naples
Activities
The establishment of the SEE LIFE central office marks the initial phase of the project, aiming to formalize relationships among Euro-bioimaging nodes. This central structure will streamline user access to various services and provide system support throughout the technological service cycle. A dedicated Project Manager, possessing expertise in imaging research and project management, will oversee implementation. The Project Manager will collaborate with CORIS-LS, the coordinating body for Italian life science research infrastructures. Five key activities, including defining website functionality and drafting infrastructure agreements, will ensure transparent service access, operational quality, and engagement with stakeholders for sustainability.
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