Multi-modal Spectroscopic Techniques

In this area, I am working on the usage of lab-assembled spectroscopic tools for the investigation of clinical or clinically relevant samples. A high-performance liquid phase chromatography-laser induced fluorescence system has been explored for the body fluid analysis, particularly for the pap smear analysis of patients with cervical cancer [1]. The same technique was further explored for protein profiling of breast and oral cancer patients [2-3]. Further, by using the multivariate statistical tools, we explored the laser-induced fluorescence technique as a tool for the early detection of colon cancer [4]. Recently, a hybrid laser-induced breakdown spectroscopy-Raman spectroscopy system was used for mineralogical applications which can be extended for biological samples also [5]. Of late, the research is focused on the development of nanoplaforms for biomedical and therapeutical applications [6-9]


1) Proceedings of SPIE, Vol 6441, Imaging, Manipulation and Analysis of Biomolecules, Cells and Tissues, 64410B (2007)

2) Proceedings of SPIE, Vol 6430, Advanced Biomedical Clinical Systems V, 64300 W (2007)

3) Journal of Biomedical Optics, 15, 067007 (2010)

4) Journal of Chemometrics, 22, 408 - 416 (2008)

5) Talanta, 208, 12482 (2020)

6) Langmuir, 35, 31, 10139-10150 (2019

7) Coordination Chemistry Reviews, 419, 213356, (2020)

8) International Journal of Pharmaceutics, 588, 119735 (2020)

9) International Journal of Biological Macromolecules 178, 444 (2021)