understanding & engineerinG

human T cell immunity

Our goal is to understand and engineer human T cell immunity to treat infectious diseases and cancer.

T cells recognize parts of infected cells or tumor cells. To do so, they are equipped with receptors. Every human being has about 100 million different T cell receptors! T cells are like a population inhabiting the human organism and their receptor is their unique finger print. They usually protect you, sometimes they can cause problems and they continuously change.

We aim to understand how T cell populations evolve based on their T cell receptor – and then to use this knowledge therapeutically. For this, we re-program T cells by replacing their T cell receptor through means of genetic engineering.