Publications
# co-corresponding author · * co-first author
Publications
# co-corresponding author · * co-first author
2026
67. Cha S, Kim J, Kim J, Kim D, Song H, Lim KS#, Chae S#. Spatial Transcriptomics for Dissecting Cellular and Molecular Heterogeneity in the Aging and Diseased Brain. Int J Mol Sci. 2026 27(14):6149
66. Bin BH, Brito S, Park SJ, Yoon KB, Heo H, Jo H, Chae S, Weon BM, Cho SK, Kim J. Nitrogen-oxygen plasma induces selective cancer cell death via apoptosis with lipid-peroxidation-associated mechanisms across multiple cancer cell models. Sci Rep. 2026 doi: 10.1038/s41598-026-59131-4
65. Kang M, Song S, Kim B, Kim K, Jeong T, Um S, Chae S#, Kim J#. Lateral habenula 5-HT4 receptor signaling restores social novelty preference after acute isolation. Cell Rep. 2026 45(6):117458 (IF: 7.7)
64. Lee JD, Kim HY, Im JE, Lee H, Park J, Park K, Kang K, Jeong HG, Chae S, Hwang D, Han BS, Cho WS, Kim S, Kim KB. Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice. Arch Toxicol. 2026 doi: 10.1007/s00204-026-04466-0
63. Kim Y, Jeon H, Gwon SY, Chae S#, Mun JY#. Metformin attenuates cuprizone-induced mitochondrial dysfunction and senescence-associated changes in primary neuronal cells. Cell Struct Funct. 2026 51(1):215-226
62. Woo SH, Chae S, Rhie BH, Jo WJ, Park YJ, Choi MJ, Matam V, Ramakrishna S, Hwang D, Kim KS. cP1P Maintains Long-Term Pluripotency in Human Pluripotent Stem Cells. Int J Stem Cells. 2026 19(3):320-330
61. Woo H, Kim SW, Kim S, Chae S#, Kim J#. Entrectinib attenuates LPS-induced neuroinflammation by inhibiting JNK, p38, and AKT pathways and ameliorates cognitive impairment. Arch Pharm Res. 2026 49(3):393-415 (IF: 8.2)
60. Choi SJ, Choi J, Kim J, Kim SH, Cho HG, Lim MY, Chae S, Lim KS, Ha SJ, Kim HO. Advanced Technologies in Extracellular Vesicle Biosensing: Platforms, Standardization, and Clinical Translation. Molecules. 2026 31(2):227
59. Lee HJ, Park JH, Kim DY, Kim DY, Yi MJ, Choi WS, Na HH, Chae S, Oh YT, Kim KC. Copper modulates cell fate through the PLK1-FOXO3a-β-catenin signaling pathway by differentially regulating cuproptosis and EMT. Apoptosis. 2026 31(1):12
2025
58. Lim SY, Kim Y, Han S, Kim HO, Ha SJ, Park JA, Yun J, Chae S, Won YW, Lim KS. CliCAR: A non-genetic CAR engineering strategy to empower NK cells for targeted cancer immunotherapy. Biomed Pharmacother. 2025 193:118691
57. Kim Y, Kwak J, Lim M, Lim SY, Chae S, Ha SJ, Won YW, Kim HO, Lim KS. Advances in PCL, PLA, and PLGA-Based Technologies for Anticancer Drug Delivery. Pharmaceutics. 2025 17(10):1354
56. Lim SY, Kim Y, Kim H, Han S, Yun J, Kim HO, Ha SJ, Chae S, Won YW, Lim KS. Surface Engineering of Natural Killer Cells with Lipid-Based Antibody Capture Platform for Targeted Chemoimmunotherapy. Pharmaceutics. 2025 17(10):1285
55. Kim Y, Lim SY, Kim HO, Ha SJ, Park JA, Won YW, Chae S#, Lim KS#. Combination Strategies with HSP90 Inhibitors in Cancer Therapy: Mechanisms, Challenges, and Future Perspectives. Pharmaceuticals. 2025 18(8):1083
54. Hwang YN, Park JH, Na HH, Kwon TH, Park JS, Chae S, Oh YT, Kim KC. Cannabichromene: integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy. Cell Death Discov. 2025 11(1):377
53. Brito S, Heo H, Kim J, Cha B, Jeong Y, Choi W, Shrestha C, Lee GH, Park SJ, Yoon KB, Hashi KO, Kim ST, Chae S, Cho SK, Weon BM, Kim J, Bin BH. Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control. Dev Cell. 2025 60(9):1304-1320.e7
2024
52. Kyung DS*, Lee E*, Chae S*, Son Y*, Moon YJ, Hwang D, Kim JK, Lee YH, Seong JK. Single-cell transcriptomic analysis identifies dynamic activation of cellular signaling pathways instructing beige adipogenesis. Exp Mol Med. 2024 56(10):2309-2322
(IF: 12.8, Selected as BRIC 한빛사 논문)
51. Choi J, Jung S, Kim J, So D, Kim A, Kim S, Choi S, Yoo E, Kim JY, Jang YC, Lee H, Kim J, Shin HS, Chae S#, Keum S#. ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy. Cell Rep. 2024 43(9):114659 (IF: 8.8)
50. Chae S*, Lee HJ*, Lee HE*, Kim J, Jeong YJ, Lin Y, Kim HY, Leriche G, Ehrlich RS, Lingl SC, Seo MD, Lee YH, Yang J, Kim JI, Hoe HS. The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta. J Neuroinflamm. 2024 21(1):200 (IF: 9.3)
49. Lee HE, Jung M, Choi K, Jang JH, Hwang SK, Chae S, Lee JH, Mun JY. L-serine restored lysosomal failure in cells derived from patients with BPAN reducing iron accumulation with eliminating lipofuscin. Free Radic Biol Med. 2024 221:273-282
48. Yoon JH, Lee D, Lee C, Cho E, Lee S, Gassiot AC, Kim K, Chae S, Dennis EA, Suh PG. Paradigm shift required for translational research on the brain. Exp Mol Med. 2024 56(5):1043-1054
47. Kim J*, Kim TJ*, Chae S*, Ha H, Park Y, Park S, Yoon CJ, Lim SA, Lee H, Kim J, Kim J, Im K, Lee K, Kim J, Kim D, Lee E, Shin MH, Park SI, Rhee I, Jung K, Lee J, Lee KH, Hwang D, Lee KM. Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma. Mol Cancer. 2024 23(1):45
(IF: 37.3, Selected as BRIC 한빛사 논문)
46. Lee S*, Kim H*, Kim BS*, Chae S*, Jung S, Lee JS, Yu J, Son K, Chung M, Kim JK, Hwang D, Baek SH, Jeon NL. Angiogenesis-on-a-chip coupled with single-cell RNA sequencing reveals spatially differential activations of autophagy along angiogenic sprouts. Nat Commun. 2024 15(1):230
(IF: 16.6, Selected as BRIC 한빛사 논문)
45. Lee S*, Choi E*, Chae S*, Koh JH, Choi Y, Kim JG, Yoo SA, Hwang D, Kim WU. Identification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling. Ann Rheum Dis. 2023 82(8):1035-1048
(IF: 27.4, Selected as BRIC 한빛사 논문)
44. Yoo S, Jeong YH, Choi HH, Chae S, Hwang D, Shin SJ, Ha SJ. Chronic LCMV infection regulates the effector T cell response by inducing the generation of less immunogenic dendritic cells. Exp Mol Med. 2023 55(5):999-1012
43. Oh JH, Jo S, Park KW, Lee EJ, Lee SH, Hwang YS, Jeon HR, Ryu Y, Yoon HJ, Chun SM, Kim CJ, Kim TW, Sung CO#, Chae S#, Chung SJ#. Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson’s disease. Exp Mol Med. 2023 55(3):555-564
(IF: 12.8, Selected as BRIC 한빛사 논문)
42. Kim J, Han JY, Lee Y, Kim K, Choi YP#, Chae S#, Hoe HS#. Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson's disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy. Mol Brain. 2023 16(1):7
41. Vadevoo SMP, Gunassekaran GR, Yoo JD, Kwon TH, Hur K, Chae S, Lee B. Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p. Front Immunol. 2022 13:976196
40. Brito S, Heo H, Cha B, Lee SH, Chae S#, Lee MG#, Kwak BM#, Bin BH#. A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins. Sci Rep. 2022 12(1):14478
39. Taleahmad S, Salari A, Samadian A, Chae S, Hwang D, Lee B, Bayarsaikhan D, Bayarsaikhan G, Lee J, Park JH, Hassani SN, Baharvand H, Hosseini Salekdeh G. BMP4 signaling plays critical roles in self-renewal of R2i mouse embryonic stem cells. Biochem Biophys Res Commun. 2022 617(Pt 1):8-15
38. Moon Y*, Chae S*, Yim S*, Yang EG, Choe J, Hyun J, Chang R, Hwang D, Park H. Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia. iScience. 2022 25(7):104517
37. Brito S, Baek JM, Cha B, Heo H, Lee SH, Lei L, Jung SY, Lee SM, Lee SH, Kwak BM, Chae S#, Lee MG#, Bin BH#. Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling. J Dermatol Sci. 2022 106(3):159-169
36. Lee JS, Chae S, Nan J, Koo YD, Lee SA, Park YJ, Hwang D, Han W, Lee DS, Kim YB, Chung SS, Park KS. SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ. Cell Rep. 2022 38(8):110408
35. Lee HE, Jung MK, Noh SG, Choi HB, Chae S#, Lee JH, Mun JY#. Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts. Int J Mol Sci. 2021 22(21):11650
34. Vadevoo SMP, Gunassekaran GR, Lee C, Lee N, Lee J, Chae S, Park JY, Koo JH, Lee B. The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages. Proc Natl Acad Sci U S A. 2021 118(37):e2102434118
33. Lim SM, Hong MH, Ha SJ, Hwang D, Chae S, Koh YW, Choi EC, Kim SH, Kim DH, Yoon SO, Kim HR. Overexpression of poliovirus receptor is associated with poor prognosis in head and neck squamous cell carcinoma patients. J Cancer Res Clin Oncol. 2021 147(9):2741-2750
32. Lim SA, Moon Y, Shin MH, Kim TJ, Chae S, Yee C, Hwang D, Park H, Lee KM. Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways. Cancers. 2021 13(8):1904
31. Lee JB, Hong MH, Park SY, Chae S, Hwang D, Ha SJ, Shim HS, Kim HR. Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma. Sci Rep. 2021 11(1):8551
30. Oh S*, Jang AY*, Chae S*, Choi S, Moon J, Kim M, Spiekerkoetter E, Zamanian RT, Yang PC, Hwang D, Byun K, Chung WJ. Comparative analysis on the anti-inflammatory/immune effect of mesenchymal stem cell therapy for the treatment of pulmonary arterial hypertension. Sci Rep. 2021 11(1):2012
29. Jo H, Jang D, Park SK, Lee MG, Cha B, Park C, Shin YS, Park H, Baek JM, Heo H, Brito S, Hwan HG, Chae S, Yan SW, Lee C, Min CK, Bin BH. Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis. J Ginseng Res. 2021 45(1):126-133
28. Goughnour PC, Park MC, Kim SB, Jun S, Yang WS, Chae S, Cho S, Song C, Lee JH, Hyun JK, Kim BG, Hwang D, Jung HS, Gho YS, Kim S. Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity. J Extracell Vesicles. 2020 10(1):e12029
27. Moon Y, Kim I, Chang S, Park B, Lee S, Yoo S, Chae S, Hwang D, Park H. Hypoxia regulates allele-specific histone modification of the imprinted H19 gene. Biochim Biophys Acta Gene Regul Mech. 2020 1863(11):194643
26. Jo W, Min BS, Yang HY, Park NH, Kang KK, Lee S, Chae S#, Ma ES#, Son WC#. Sappanone A Prevents Left Ventricular Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model. Int J Mol Sci. 2020 21(18):6935
25. Lee BR*, Chae S*, Moon J, Kim MJ, Lee H, Ko HW, Cho BC, Shim HS, Hwang D, Kim HR, Ha SJ. Combination of PD-L1 and PVR determines sensitivity to PD-1 blockade. JCI Insight. 2020 5(14):128633
24. Lee MG*, Chae S*, Nakajima K, Ibi M, Sano H, Hara T, Jo H, Takagishi T, Cha B, Baek JM, Yoshigai E, Ohashi T, Irié T, Sano S, Lee JS, Fukada T, Bin BH. Implication of the zinc-epigenetic axis in epidermal homeostasis. J Dermatol Sci. 2020 98(3):203-206
23. Jo W, Kang KK, Chae S#, Son WC#. Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model. Int J Mol Sci. 2020 21(4):1489
22. Lee JD, Kim HY, Kang K, Jeong HG, Song MK, Tae IH, Lee SH, Kim HR, Lee K, Chae S, Hwang D, Kim S, Kim HS, Kim KB, Lee BM. Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats. Arch Toxicol. 2020 94(3):887-909
21. Lee N, Jae Y, Kim M, Cho T, Lee C, Hong YR, Hyeon DY, Ahn S, Kwon H, Kim K, Jung JH, Chae S, Shin JO, Bok J, Byun Y, Hwang D, Koo J. A pathogen-derived metabolite induces microglial activation via odorant receptors. FEBS J. 2020 287(17):3841-3870
20. Nakajima K, Lee MG, Bin BH, Hara T, Takagishi T, Chae S, Sano S, Fukada T. Possible involvement of zinc transporter ZIP10 in atopic dermatitis. J Dermatol. 2020 47(2):e51-e53
19. Kim K, Lee DH, Park S, Jo SH, Ku B, Park SG, Park BC, Jeon YU, Ahn S, Kang CH, Hwang D, Chae S, Ha JD, Kim S, Hwang JY, Kim JH. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 9(1):19654
18. Choi H, Kim HJ, Yang J, Chae S, Lee W, Chung S, Kim J, Choi H, Song H, Lee CK, Jun JH, Lee YJ, Lee K, Kim S, Sim HR, Choi YI, Ryu KH, Park JC, Lee D, Han SH, Hwang D, Kyung J, Mook-Jung I. Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models. Aging Cell. 2019 19(1):e13081
17. Lee MG*, Choi MA*, Chae S*, Kang MA, Jo H, Baek JM, In KR, Park H, Heo H, Jang D, Brito S, Kim ST, Kim DO, Lee JS, Kim JR, Bin BH. Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy. Sci Rep. 2019 9(1):15042
16. Ahn CH*, Chae S*, Oh TJ, Hwang D, Cho YM. Dynamic Adaptive Changes of the Ileum Transposed to the Proximal Small Intestine in Rats. Obes Surg. 2019 29(8):2399-2408
15. Chae S*, Kim S*, Koo YD*, Lee JW, Kim H, Ahn BY, Ha Y, Kim Y, Jang MG, Koo K, Choi SH, Lim S, Park YJ, Jang HC, Hwang D, Lee S, Park KS. A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles. Exp Mol Med. 2018 50(9):1-14
14. Han H, Chae S, Hwang D, Song J. Attenuating MKRN1 E3 ligase-mediated AMPKα suppression increases tolerance against metabolic stresses in mice. Cell Stress. 2018 Oct 11;2(11):325-328
13. Lee MS, Han HJ, Han SY, Kim IY, Chae S, Lee CS, Kim SE, Yoon SG, Park JW, Kim JH, Shin S, Jeong M, Ko A, Lee HY, Oh KJ, Lee YH, Bae KH, Koo SH, Kim JW, Seong JK, Hwang D, Song J. Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation. Nat Commun. 2018 9(1):3404
12. Park S, Park J, Jung H, Jang J, Ahn S, Kim Y, Suh P, Chae S, Yoon JH, Ryu SH, Hwang D. A secretome profile indicative of oleate induced proliferation of HepG2 hepatocellular carcinoma cells. Exp Mol Med. 2018 50(8):1-14
11. Ghazizadeh Z, Fattahi F, Mirzaei M, Bayersaikhan D, Lee J, Chae S, Hwang D, Byun K, Tabar MS, Taleahmad S, Mirshahvaladi S, Shabani P, Fonoudi H, Haynes PA, Baharvand H, Aghdami N, Evans T, Lee B, Salekdeh GH. Prospective Isolation of ISL1(+) Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy. Stem Cell Reports. 2018 10(3):848-59
10. Kim Y, Kwon OK, Chae S, Jung HJ, Ahn S, Jeon JM, Sung E, Kim S, Ki SH, Chung KW, Chung HY, Jung YS, Hwang DH, Lee S. Quantitative Proteomic Analysis of Changes Related to Age and Calorie Restriction in Rat Liver Tissue. Proteomics. 2018 18(5-6):e1700240
9. Lee S*, Lee J*, Chae S*, Moon Y*, Lee HY, Park B, Yang EG, Hwang D, Park H. Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia. Nucleic Acids Res. 2017 45(20):11643-57
(IF: 11.6, Selected as BRIC 한빛사 논문)
8. Lee H*, Chae S*, Park J, Bae J, Go EB, Kim SJ, Kim H, Hwang D, Lee SW, Lee SY. Comprehensive proteome profiling of platelet identified a protein profile predictive of responses to an antiplatelet agent sarpogrelate. Mol Cell Proteomics. 2016 15(11):3461-3472
7. Jo DH*, Bae J*, Chae S*, Kim JH, Han JH, Hwang D, Lee SW, Kim JH. Quantitative Proteomics Reveals β2 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability. Mol Cell Proteomics. 2016 15(5):1681-91
6. Koo YD, Choi JW, Kim M, Chae S, Ahn BY, Kim M, Oh BC, Hwang D, Seol JH, Kim YB, Park YJ, Chung SS, Park KS. SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. Diabetes. 2015 64(7):2420-31
5. Park H, Bae J, Kim H, Kim S, Kim H, Mun DG, Joh Y, Lee W, Chae S, Lee S, Kim HK, Hwang D, Lee SW, Paek E. Compact variant-rich customized sequence database and a fast and sensitive database search for efficient proteogenomic analyses. Proteomics. 2014 14(23-24):2742-9
4. Koo BK*, Chae S*, Kim KM*, Kang MJ, Kim EG, Kwak S, Jung H, Cho YM, Choi SH, Park YJ, Shin CH, Jang HC, Shin CS, Hwang D, Yi EC, Park KS. Identification of Novel Auto-antibodies in Type 1 Diabetic Patients using a High-density Protein Microarray. Diabetes. 2014 63(9):3022-32
3. Kim SJ*, Chae S*, Kim H*, Mun DG, Back S, Choi HY, Park KS, Hwang D, Choi SH, Lee SW. A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus. Mol Cell Proteomics. 2014 13(3):811-22
2. Chae S*, Ahn BY*, Byun K*, Cho YM, Yu MH, Lee B, Hwang D, Park KS. A systems approach for decoding mitochondrial retrograde signaling pathways. Sci Signal. 2013 6(264): p. rs4
1. Choi HJ, Yoon YJ, Kwon YK, Lee YJ, Chae S, Hwang D, Hwang GS, Kwon TH. Patterns of gene and metabolite define the effects of extracellular osmolality on kidney collecting duct. J Proteome Res. 2012 6;11(7):3816-28