Understanding the role of Alkyltransferases in DNA Repair, Survival, and Antimicrobial Resistance in Mycobacterium.
Microbiology, Molecular Biology, Protein Biochemistry, Understanding Alkyltransferases, Molecular Basis for the Development of Antimicrobial Resistance, DNA Repair and Stress Response in Bacteria.
Hariharan VC
I am interested in investigating the role of chromatin remodelers belonging to the INO80 family in DNA repair using radiation resistant fungus Ustilago maydis as a model organism.
Bhumika Biswas
B.Sc. in Microbiology - 2015
Govt. Holkar Science College
Understanding the role of “SOS”- regulated HNH nucleases of Mycobacterium tuberculosis in latency and reactivation.
Molecular microbiology, Mycobacterial biology, stress response, studying mechanisms of nucleases.
Gokul Raj Mohan
I am particularly interested in exploring the stress response mechanisms of mycobacteria, with a focus on the 'SOS' response. Through my research, I aim to advance our understanding of the regulatory pathways of the 'SOS' response and identify potential novel drug targets. I am also passionate about drug screening and discovering new antibacterial agents, especially as a strategy to address the growing challenges of antimicrobial resistance in mycobacteria and ESKAPE pathogens.
Neha Choudhary
Deciphering the functional Role of Nuclear Actin Related Protein 8 (ARP8) of INO80 Complex - In ribosomal RNA recognition and processing.
My research will unveil the probable role(s) of Actin related protein 8 (ARP8) in rRNA recognition, rRNA processing, ribosome biogenesis and RNA metabolism using Saccharomyces cerevisiae as a model organism and further elucidating its molecular role(s) beyond chromatin remodeling .
Sakshi Keshari
Investigating the Role of “SOS” Response Regulated VapBC40 Toxin-Antitoxin Module in Stress Tolerance and Survival of Mycobacterium tuberculosis.
My research interest is towards the development of novel therapies that are required in the era of expanding antibiotic resistance to target persistent Mycobacterium tuberculosis. The aim of the project is to determine the role of SOS response regulated VapBC40 system (a virulence associated protein complex present in Mtb) and to investigate its molecular, biochemical and biophysical properties.
Kalya Ankeet Rao
Understanding the role of a LexA-like protein in DNA-damage response in nosocomial pathogen Acinetobacter baumannii to combat antimicrobial resistance, SOS response, DNA-damage response, Induced Mutagenesis, molecular biology, genetics, antimicrobial resistance and adaptation, Microbiology, Biochemistry, Protein Biology, Bioinformatics, and Genome Analysis.
Muktesh K Sahu
Investigating the molecular mechanism and biophysical aspects of bacterial biofilm formation and its impact on the host-pathogen interaction & promoting antimicrobial resistance.
Microbiology, Molecular biology, Biophysics, biofilm formation, SOS response, Bacterial motility Host-pathogen interaction, Antimicrobial resistance.
ResearchGate, Google Scholar, ORCID
Swarnali Das
Mycobacterial stress response (SOS response) and antimycobacterial resistance.
Chandan R Chand
B.Sc. in Zoology -2019
Sambalpur UniversityCurrently engaged in research focusing on Anti-microbial Resistance (AMR) and microbial adaptation of Staphylococcus aureus. My work involves the mechanistic, pharmacokinetic, and toxicological evaluation of a patented novel Platinum-NHC complex against MRSA, aimed at future clinical development.
This research explores the molecular mechanisms of action of these novel compounds against different antimicrobial-resistant MRSA strains.
Gouri Saritha Nair
Understanding how chromatin dynamics in microorganisms regulate stress responses and host-pathogen interactions, with a specific focus on the plant pathogen Ustilago maydis.
Exploring how epigenetic and chromatin-level changes may influence pathogenicity and interaction with the host defence.
Nikhat Parveen
Investigating molecular mechanisms and biophysical aspects of Bacillus subtilis biofilm, host-pathogen interactions, antimicrobial resistance, using microbiology, molecular biology, immunology, and biophysics approaches.
Ankur Chattopadhyay
Identification, Functional and Structural Characterization of a novel Extracellular Nuclease from Acinetobacter baumannii, which is one of the members of the WHO recognized 'ESKAPE' group of pathogens.
Jitu Halder
‘ESKAPE’ Pathogens, Roles of different types of Efflux pumps in antimicrobial resistance (MATE or Multi Drug and toxic compound extrusion transporter), Protein Biochemistry, Molecular Biology
Tamonash Debnath
Research Interest:
Exploring in various aspects of host-microbiota interactions, such as how bacterial extracellular vesicles are involved in pathogenesis as well as antimicrobial defence mechanisms against competing species.
Understanding chromatin remodelling complexes in certain species modulate gene expression, biofilm formation, lifestyle switching, and antibiotic resistance.
Dr. Poonam Jangir
Currently exploring different available novel compounds to counter Antimicrobial Resistance (AMR) and Antifungal Resistance (AFR) and enhancing their effectiveness via nanoformulations.
Dr. Abdul Akhir
To explore the therapeutic options against Multidrug resistance (MDR) Acinetobacter baumannii.
M.Sc. in Microbiology - 2024
Periyar University , T.N.
LexA family transcriptional regulator in SOS-induced mutagenesis and antimicrobial resistance (AMR) of multi-drug resistant Acinetobacter baumannii. Isolation and characterization of extracellular vesicles (EVs) from different bacteria and fungi to check therapeutic potential against M. tuberculosis.
M.Sc. in Biotechnology - 2023
Jaypee University , H.P.
My research focuses on identifying small-molecule inhibitors to cripple the mycobacterial “SOS” response mutagenic axis and their potential against antimicrobial resistance (AMR).
M.Sc. in Botany - 2021
Bharathiar University , T.N.
Isolation and characterization of antibiotic-resistant bacteria from natural environments to investigate their adaptive mechanisms. Isolation of plant rhizosphere-associated microbes to evaluate their functional roles and potential in nutrient regulation.
M.Sc. in Bioinformatics - 2023
Sri Krishna Arts and Science College, T.N.
Currently exploring the effect of different small molecules on Mycobacterial SOS response and antimicrobial resistance (AMR).
azizk@iitk.ac.in
Ph.D. Students:
Dr. Prem Anand Murugan: Effect of Chemical Cues on the Regulation of Bacillus subtilis Lifestyle (May 2024)
(Current affiliation: Postdoctoral fellow at Scojen Institute, Herzliya, Tel Aviv, Israel)
Dr. Chitral Chatterjee: Targeting master-regulator LexA to toggle SOS response: tactics to regulate the mutagenic balance in mycobacteria (April 2024)
(Current affiliation: Postdoctoral fellow at Brigham Young University, Utah, USA)
Dr. Akshat Verma: Investigation of Biogeochemical processes governing arsenic release in mixed-oxic state groundwater in the middle-Gangetic plains of India (October 2023)
(Current affiliation: Postdoctoral fellow at Texas A&M University, Texas, USA)
Master (M.Tech) Students:
1. Vasvi Tripathi (2015)
2. Megha Jhanji (2015)
3. Sachin Deshpandey (2015)
4. Monika Sharma (2016)
5. Aekagra Singh (2018)
6. Somya Das (2019)
Master Dissertation Students:
Shreyansh Singh (2025)
Ananya Singh (2025)
Samriddhi Pathak (2023)
Yaseen Nazir (2023)
Debasmita Chatterjee (2019)
Monica Saxena (2018)
Research Project Assistants:
Sathishkumar Lakshmipathy
Rakesh kumar
Hariharan VC
Priyanka Amule
Sonali Puri
Vikas Choudhary
Diwyansh Raj
Rakesh Kumar
Shreyesee
Uthesh Umapathy
Piyush Porwal
Rahul Thangadurai
Post-doctoral Fellows:
1. Dr. Muthu Prasad
2. Dr. Ujjwal Kumar Trivedi
Research Interns:
Abhiraj Nair
Aditi Sharma
Anushka Mishra
Krishnapraneetha Muppana
Maharsh Jayadeep Jayawant
Rishitha L
Sankalp Mishra
Sankeerthana G
Sejal Gupta
Shivangi Shukla
Sushma K
Vaishnavi T
Vedant
Yeshwanth D