Publications and Patents

2025

38. Afjal Ansari, Naveen Kumar Verma, Saravanan Matheshwaran, Nishith Verma,  Selective Conversion of Aqueous Co to Formate Using the Waste Water Isolated Microalage in a Packed Bed Photobioreactor Under Flow Condition, Chemical Engineering Journal, 521, 166894

37. Anupam Halder, Gokul Raj Mohan, Saravanan Matheshwaran*, Shikhar Krishn Jha*. Green synthesis of neem (Azadirachta indica) functionalised zinc oxide with enhanced antimicrobial properties Next Materials, 8, 100725 

36. Santhalingam Gayathri, Manikka Kubendran Aravind, Vykuntaraju K Gowda, Perumal Varalakshmi, Chitral Chatterjee, Saravanan Matheshwaran, Stephanie Efthymiou, Henry Houlden, Balasubramaniem Ashokkumar. Brown-Vialetto-Van Laere syndrome patients with unusual phenotypes from Indian ethnicity: Functional analysis of clinical variants in SLC52A2 and SLC52A3 genes. Brain and Development, 47, 104355 

2024

35. Akshat Verma, Hariharan Vedi Chinnasamy, Bhumika Biswas, Abhas Singh, Saravanan Matheshwaran* Biochemical and steady-state kinetic analyses of arsenate reductases from an arsenic-tolerant strain of Citrobacter youngae IITK SM2. Biochemical and Biophysical Research Communications, 739, 150936.

34. Kalpana Rathore, Dheeraj Upadhyay, Noopur Verma, Ajay Kumar Gupta, Saravanan Matheshwaran, Sandeep Sharma, Vivek Verma. Asymmetric Janus Nanofibrous Agar-Based Wound Dressing Infused with Enhanced Antioxidant and Antibacterial Properties. ACS Applied Bio Materials, 7, 7608–7623.

33. Dhananjay Gautam, Hemlata Meena, Saravanan Matheshwaran, Sivasurender Chandran.  Harnessing density to control the duration of intermittent Lévy walks in bacterial turbulence. Physical Review E, 110, L012601.

32. Prem Anand Murugan, Muktesh Kumar Sahu, Manish Kumar Gupta, T. Sabari Sankar, Sivasurender Chandran*, Saravanan Matheshwaran*.  Deciphering the Influence of NaCl on Social Behaviours of Bacillus subtilis. Royal Society Open Science, 11, 240822.

31. Chitral Chatterjee, Mohan Gokul Raj, Chinnasamy Hariharan V, Bhumika Biswas, Veena Sundaram, Ashutosh Srivastava, Saravanan Matheshwaran*.  Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteria. Journal of Biological Chemistry. 300-9, 107650

30. Kajal Chaudhary, Bhumika Agrahari, Bhumika Biswas, Sidharth Chopra, Santosh Misra, Saravanan Matheshwaran*, Ritika Gautam Singh. Pyridine-2,6-Dicarboxamide Proligands and their Cu(II)/Zn(II) Complexes Targeting Staphylococcus aureus for the Attenuation of In Vivo Dental Biofilm. Advanced Healthcare Materials. 13-20, 2400378

2023

29. Ritu Gupta, Hariharan V. Chinnasamy, Dipak Sahu, Saravanan Matheshwaran*, Chanchal Sow, Prakash Chandra Mondal.  Spin-dependent electrified protein interfaces for probing the CISS effect. Journal of Chemical Physics. 159, 024708

28. Mandeep Kaur, Ritesh Thakare, Arindom Bhattacherya, Prem Anand Murugan, Grace Kaul, Manjulika Shukla, Alok Kr. Singh, Saravanan Matheshwaran*, Sidharth Chopra, Jitendra K. Bera. Antimicrobial efficacy of a hemilabile Pt(II)-NHC compound against drug-resistant S. aureus and Enterococcus. Dalton Transactions. 52, 1876-1884

2022

27. Soneya Majumdar, Umang Gupta, Hariharan Chinnasamy, Sathishkumar Laxmipathy, Saravanan Matheshwaran*.  Zn²⁺ induced conformational change affects the SAM binding in a mycobacterial SAM-dependent methyltransferase. ACS Omega, 7, 35901–35910.

26. Viral Rawat, Sona Tiwari, Shweta Khanna, Umang Gupta, S. N. C. Sridhar, Dharmendra Yadav, Grace Kaul, Abdul Akhir, Deepanshi Saxena, Saravanan Matheshwaran, Sidharth Chopra, Dharmaraja Allimuthu.  Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus targets peptidoglycan biosynthesis. Chemical Communications, 58, 11669–11672.

25. Yaswanth K. Penke, Premanand Murugan, Iram Malik, Saravanan Matheshwaran, Janakarajan Ramkumar, Kamal K. Kar.  Antibacterial and arsenic remediation insights using Cu₀.₅₂Al₀.₁Fe₀.₄₇O₄/rGO hybrid nanomaterials. Environmental Science and Pollution Research. https://doi.org/10.1007/s11356-022-22169-8

24. Akshat Verma, Prem Anand Murugan, Hariharan Vedi Chinnasamy, Abhas Singh, Saravanan Matheshwaran*.  Identification and genome analysis of an arsenic-metabolizing strain of Citrobacter youngae IITK SM2 in Middle Indo-Gangetic Plain Groundwater. Biomed Research International. https://doi.org/10.1155/2022/6384742

23. Prem Anand Murugan, Manish Kumar Gupta, T. Sabari Sankar, Sivasurender Chandran, Saravanan Matheshwaran*. NaCl triggers the sessile-to-motile transition of Bacillus subtilis. bioRxiv. https://doi.org/10.1101/2022.02.15.480532

2021

22. Chitral Chatterjee, Soneya Majumdar, Sachin Deshpande, Deepak Pant, Saravanan Matheshwaran*.  Real-time kinetic studies of Mycobacterium tuberculosis LexA-DNA interaction. Bioscience Reports, BSR20211419. https://doi.org/10.1042/BCJ20210434

2020

21. Irfan Qayoom, Rahul Verma, Prem Anand Murugan, Deepak Bushan Raina, Arun Kumar Teotia, Saravanan Matheshwaran, et al.  A biphasic nanohydroxyapatite/calcium sulphate carrier for sustained antibiotic release and biofilm prevention. Scientific Reports, 10, 14128. https://doi.org/10.1038/s41598-020-70726-3

20. Arjak Bhattacharjee, Anshul Gupta, Madhu Verma, et al.  Effect of Zn and Co doping on antibacterial efficacy and cytocompatibility of spark plasma sintered hydroxyapatite. Journal of the American Ceramic Society. https://doi.org/10.1111/jace.17077

2019

19. Arjak Bhattacharjee, Anshul Gupta, Madhu Verma, et al.  Antibacterial and magnetic response of site-specific cobalt-incorporated hydroxyapatite. Ceramics International, 46(1), 513–522.

18. A. Gayen, D. Kumar, M. Saravanan, et al.  Modulating role of pH on small molecule accumulation in E. coli using nonlinear spectroscopy. Analytical Chemistry, 91, 7662–7671.

17. Sunaina S, Chinchwadkar S, Aher A, Saravanan M, Ravi Manjithaya.  Exocyst subcomplex functions in autophagosome biogenesis by regulating Atg9 trafficking. Journal of Molecular Biology, 431, 2821–2834.

16. Arjak Bhattacharjee, Anshul Gupta, Madhu Verma, et al.  Zinc-substituted hydroxyapatite with antibacterial and cyto/hemo-compatibility. Ceramics International, 45, 12225–12233.

15. Prem Anand Murugan, Hariharan VC, Shankar H, Singh A, Saravanan Matheshwaran.  Genome sequence of Bacillus subtilis subsp. subtilis strain IITK SM1. Microbiology Resource Announcements, 8(6). https://doi.org/10.1128/MRA.01330-18

2017

14. Sellamuthu Karthi, Rajeswari Mohan, Franscisco, Thangaraj K, Saravanan Matheshwaran, Perumal Varalakshmi, Balasubramaniem Ashokkumar. 3’-UTR polymorphism rs2229611 in the human G6PC1 gene affects mRNA stability and its expression and confers risk for GSD-Ia. Clinica Chimica Acta 471, 46–54 (2017). doi:10.1016/j.cca.2017.05.016.

2016

13. Shakambari G, Anand Kumar B, Angelaa Lincy MJ, Rai SK, Ahamed TQ, Ashokkumar B, Saravanan M, Mahesh A, Varalakshmi P. Glutaminase free L-asparaginase from a marine isolate Bacillus tequilensis PV9W: production, purification, characterization and its biological applications. RSC Advances 6, 25943–25951 (2016).

2015

12. Trivedi U, Kaushik S, Kunjadia P, Saravanan M, Nagaraja V, Archana G, Nareshkumar G. Functional expression and purification of Anabaena PCC 7120 XisA protein. Protein Expression and Purification 118, 64–69 (2015). doi:10.1016/j.pep.2015.09.027.

2012

11. Saravanan M, Wuerges J, Bose D, Cook N, Zhang X, Wigley DB. Interactions between the nucleosome histone core and Arp8 in the INO80 Chromatin Remodelling Complex. PNAS 109, 20883–20888 (2012). doi:10.1073/pnas.1214735109.

2011

10. Vasu K, Saravanan M, Nagaraja V. Endonuclease active site plasticity allows DNA cleavage with diverse alkaline earth and transition metal ions. ACS Chemical Biology 6, 934–942 (2011). doi:10.1021/cb200107y.

2010

9. Vasu K, Saravanan M, Rajendra BV, Nagaraja V. Generation of a manganese-specific restriction endonuclease with nicking activity. Biochemistry 49, 8425–8433 (2010). doi:10.1021/bi101035k.

2009

8. Swapna G, Saravanan M, Nagaraja V. Identification and characterization of Mg²⁺ binding residues in transactivator protein C of phage Mu. Biochemistry 48, 2347–2354 (2009). doi:10.1021/bi8022448.

2008

7. Saravanan M, Vasu K, Nagaraja V. Evolution of sequence specificity in a restriction endonuclease. PNAS 105, 10344–10347 (2008). doi:10.1073/pnas.0804974105.

6. Vasu K, Saravanan M, Nagaraja V. Structural integrity of ββα-metal finger motif and its effect on stable protein-DNA complex formation in R.KpnI. Biochimica et Biophysica Acta – Proteins and Proteomics 1784, 32320–32326 (2008).

2007

5. Saravanan M, Vasu K, Ghosh S, Nagaraja V. Two distinct roles for Zn²⁺ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease. Journal of Biological Chemistry 282, 32320–32326 (2007).

4. Saravanan M, Vasu K, Kanakaraj R, Rao DN, Nagaraja V. DNA binding and kinetics with R.KpnI reveal lower degree of discrimination at non-canonical sequences. Nucleic Acids Research 35, 2777–2786 (2007).

2004

3. Saravanan M, Bujnicki JM, Cymerman IA, Rao DN, Nagaraja V. Type II restriction endonuclease R.KpnI is a member of the HNH nuclease superfamily. Nucleic Acids Research 32, 6129–6135 (2004).

2. Chandrashekaran S, Saravanan M, Radha DR, Nagaraja V. Ca²⁺ mediated site-specific DNA cleavage and suppression of promiscuous activity of KpnI restriction endonuclease. Journal of Biological Chemistry 279, 49736–49740 (2004).

2003

1. Saravanan M, Elango K, Chandrashekaran S, Anand N, Nagaraja V. A new type II restriction endonuclease, OfoI from nonheterocystous cyanobacterium Oscillatoria foreaui. Current Science 85, 188–191 (2003). (Cover Page Article)

Reviews & Book Chapters: 

1. Majumdar S, Sing P and Saravanan M* Chapter 1: Functional Genomics Current Developments in Biotechnology and Bioengineering, Book 2: Functional Genomics and Metabolic Engineering Elsevier 

2. Ujwalkumar Trivedi, Sakshi Keshari, Chitral Chatterjee, Saravanan Matheshwaran*, Nagarajan Kayalvizhi, Muthukaligan Khrishnan and Neelamegam Rameshkumar* Recent Advances in Analytical Techniques to Analyse the Purity of Recombinant Proteins. Fundamentals of Recombinant Protein Production, Purification and Characterization. 1st Edition (ELSEVIER 2024) ISBN: 9780323983884 .

Patents:

1. Zhu Z, Nagaraja V and Saravanan Matheshwaran (2010), KpnI Restriction endonuclease with reduced star activity, EP 1 931773 B1, European Patent Office.
   
   

2. Nagaraja V, Saravanan Matheshwaran and Zhu Z (2012), Variant of KpnI restriction endonuclease, US 08119382 B2, US Patent Office.
   
   

3. Misra SK, Singh A, Saravanan Matheshwaran, Chatterjee N, Pandey R and Hariharan VC (2023), A formulation for inhibition of SAR-COV-2 Infection and process for preparation thereof, 460268, Indian Patent.
   
   

4. J.K. Bera, Chopra S, Saravanan Matheshwaran, Kaur M, Thakare R, Bhattacherya A and Murugan PA (2023), Antibacterial platinum N-heterocyclic carbene compounds and process of preparation thereof, 470363, Indian Patent.
   
   

5. Saravanan Matheshwaran, Misra SK, Chatterjee C and Hariharan VC (2024), A Nano-formulation for Inhibition Of Mycobacterial SoS Response and a Process of Preparation Thereof, 557921, Indian Patent.
   
   

6. Gautam R, Chaudhary K, Agrahari B, Saravanan Matheshwaran, Biswas B, Kumar A, Chaudhary A, Sonker H and Dewan S (2024), Zinc(II) based anti-microbial agents for attenuation of Staphylococcus aureus infection, 559438, Indian Patent.
   
   

7. Gautam R, Chaudhary K, Agrahari B, Saravanan Matheshwaran, Misra SK, Biswas B, Chatterjee N, Kumar A, Chaudhary A, Sonker H and Dewan S (2024), Picolonic acid derivatives based antimicrobial agents for attenuation of in-vivo dental biofilm formation, 562353, Indian Patent.
   
   

8. Gautam R, Chaudhary K, Agrahari B, Saravanan Matheshwaran, Misra SK, Biswas B, Chatterjee N, Kumar A, Chaudhary A, Sonker H and Dewan S (2024), Copper(II) based antimicrobial agents for attenuation of in-vivo dental biofilm formation, 554277, Indian Patent.
   
   

9. Rishab Omar, Naveen Kumar Verma, Nishith Verma and Saravanan Matheshwaran (2024), Method and automated apparatus for continuous upflow microbial fuel cell, 560787, Indian Patent.
   
   

10. Afjal Ansari, Naveen Kumar Verma, Nishith Verma and Saravanan Matheshwaran (2024), A Packed Bed Photobioreactor For Continuous Conversion of Aqueous CO₂ Into Starch And Method Thereof, Indian Patent.
    
    

11. Afjal Ansari, Naveen Kumar Verma, Nishith Verma and Saravanan Matheshwaran (2024), Development of a Packed Bed Photobioreactor Operated in Light On-Off Switching Mode for Aqueous CO₂ to Formate Conversion, Indian Patent.
    
    

12. Naveen Kumar Verma, Afjal Ansari, Nishith Verma and Saravanan Matheshwaran (2025), A Dual Electrochemical Cumphotochemical Packed Bed System And method Thereof, Indian Patent.