Dr. Sanghee Lee's research lies at the intersection of nanomedicine, immunoengineering, and translational biomaterials. She develops a functional biomaterials, polymer/polysacharide formulations, nanocatalysts, and gene-/cell-based therapeutics to reshape disease microenvironment and modulate immune responses through innovative delivery systems.

Her contribution spans four major areas:

1) Cancer Immunotherapy & Ablation
e.g. Eletric fields, Cryo-, Magneto-, Hyperthermia, Radio-, Photodynamic, Photothermal etc.

2) Nanomaterials & Medical Devices
e.g. MXene, Metal Oxide, Carbon dots, Silica Nanoparticles, and related platforms.

3) Image-Guided Therapy
e.g. CT/MRI/PET-imagable materials and metabolic diagnostics in obesity and T2DM.

4) Broad Bioapplications
e.g. Orthotopic Cancers, Obesity, Diabetes, Arthritis, and other Immune-related diseases.

A distinctive feature of her work is strong collaboration with hospitals and clinical researchers, ensuring therapeutic strategies are directly informed by medical needs. These collaborations highlight her commitment to bridging laboratory innovations with real-world clinical challenges. 

Her research philosophy follows the principle of "seek-verify-invetigate":

• SEEK novel materials that overcome the limits of current therapies

• VERIFY their biological functions and mechanisms

• INVESTIGATE their translational potential through rigorous preclinical and clinical pathways