We develop biomaterials and biofabrication strategies to advance tissue engineering and regenerative medicine, with a focus on the mechanical, chemical, and structural design of scaffolds that support and guide cellular activity to promote tissue repair and regeneration. Beyond biomaterial development, we also engineer novel biofabrication techniques and instruments to enable the precise fabrication and implantation of these scaffolds. Our work drives the creation of personalized, clinically translatable solutions for a wide range of regenerative applications.

Scaffold-based regenerative medicine: https://doi.org/10.1002/adhm.202401944

We design drug delivery approaches to enhance tissue repair and regeneration by enabling spatiotemporal control over the release of therapeutic agents. Our strategies range from microneedle-based systems to scaffold-integrated delivery platforms, each tailored to the specific needs of target tissues and designed with clinical translation in mind. We are currently focusing on regulating growth factor signaling and modulating immune responses to improve both the rate and quality of tissue regeneration. We further combine the above-mentioned engineered scaffolds with our novel drug delivery systems to boost the regenerative outcomes.
Microneedle-based drug delivery: https://doi.org/10.1002/adhm.202302836

Scaffold-based drug delivery: https://doi.org/10.1016/j.biomaterials.2023.122058

We develop microfluidic and lab-on-a-chip strategies for (i) point-of-care diagnostics and (ii) physiologically relevant tissue modeling. These platforms provide precise control over cellular microenvironments, fluid dynamics, biochemical gradients, and external stimuli, enabling (i) rapid separation of biological components and (ii) the in vitro replication of complex tissue structures and functions. By integrating our biomaterials and biofabrication strategies, we also leverage microfluidic-assisted biofabrication to achieve precise spatial tuning of scaffold architecture and structural cues.
POC diagnosis: https://doi.org/10.1016/j.bios.2023.115789

Tissue modeling: https://doi.org/10.1038/s41598-021-89635-0

Microfluidic-assisted biofabrication: https://doi.org/10.1063/5.0040732