Papers

[2023]

50. Yuka Muraoka, Junya Muramoto, Yu Yasuhara, Mayuko Kawatake, *Takashi Sakamoto, "Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift", Analytical Chemistry, 95(47), 17162–17165 (2023), DOI: 10.1021/acs.analchem.3c04318

[2022]

49. *Takashi Sakamoto, Zehui Yu, “Tripodal Quinone-cyanine Fluorescent Dye as a Tool for Analyzing Structural Dynamics of DNA Guanine-quadruplex”, Chemistry Letters, 51(12), 1139–1142 (2022), DOI: 10.1246/cl.220420

Highlighted as the Front Cover and Inside Cover Image

48. *Takashi Sakamoto, Zehui Yu, Yuto Otani, “Dual-color fluorescence switch-on probe for imaging G-quadruplex and double-stranded DNA in living cells”, Analytical Chemistry, 94(10), 4269–4276 (2022), DOI: 10.1021/acs.analchem.1c04804.

Highlighted as the Supplementary Cover

[2020]

47. *Takashi Sakamoto, Zhiyong Qiu, Miyu Inagaki, *Kenzo Fujimoto, “Simultaneous amino acid analysis based on 19F NMR using a modified OPA-derivatization method”, Analytical Chemistry, 92(2), 1669–1673 (2020), DOI: 10.1021/acs.analchem.9b05311.

Most Read Articles, Analytical Chemistry (Jan. – Feb, 2020)

[2019]

46. *Takashi Sakamoto, Rikuto Yamada, “Label-free in situ monitoring of the DNA hybridization chain reaction by using sequence-selective minor-groove-binding fluorophores”, ChemBioChem, 20(10), 1242–1245 (2019), DOI: 10.1002/cbic.201800738

Selected as Very Important Paper (VIP)

Highlighted as the Front Cover

[2018]

45. *Takashi Sakamoto, Daisaku Hasegawa, *Kenzo Fujimoto, “Disassembly-driven signal turn-on probes for bimodal detection of DNA with 19F NMR and fluorescence”, Organic & Biomolecular Chemistry, 16, 7157–7162 (2018), DOI: 10.1039/C8OB02218F

[2017]

44. Siddhant Sethi, Minako Ooe, Takashi Sakamoto, *Kenzo Fujimoto, “Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside”, Molecular BioSystems, 13, 1152–1156 (2017), DOI: 10.1039/C7MB00082K

43. Hong-Liang Bao, Takumi Ishizuka, Takashi Sakamoto, Kenzo Fujimoto, Tamayo Uechi, Naoya Kenmochi, *Yan Xu, “Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy”, Nucleic Acids Research, 45(9), 5501–5511 (2017), DOI: 10.1093/nar/gkx109

[2016]

42. *Kenzo Fujimoto, Kei Toyosato, Shigetaka Nakamura, Takashi Sakamoto, “RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes”, Bioorganic & Medicinal Chemistry Letters, 26(21), 5312–5314 (2016), DOI: 10.1016/j.bmcl.2016.09.035

41. *Kenzo Fujimoto, Mirei Furusawa, Shigetaka Nakamura, Takashi Sakamoto, “UVA responsive anticancer prodrugs based on photo induced electron injection into oligonucleotide having 5-halouracils”, Chemistry Letters, 45(9), 1078–1080 (2016), DOI: 10.1246/cl.160492

40. *Takashi Sakamoto, Daisaku Hasegawa, *Kenzo Fujimoto, “Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using fluorine-modified bisbenzimide derivative”, Analyst, 141(4), 1214–1217 (2016), DOI: 10.1039/C5AN02389K

Highlighted as the Back Cover

[2015]

39. Takashi Sakamoto, Minako Ooe, *Kenzo Fujimoto, “Critical effect of base pairing of target pyrimidine on the interstrand photo-cross-linking of DNA via 3-cyanovinylcarbazole nucleoside”, Bioconjugate Chemistry, 26(8), 1475–1478 (2015), DOI: 10.1021/acs.bioconjchem.5b00352

38. Vu T. Luyen, Nguyen T. K. Thanh, Shafiul Alam, Takashi Sakamoto, Kenzo Fujimoto, Hitoshi Suzuki, *Toshifumi Tsukahara, “Changing blue fluorescent protein to green fluorescent protein by using chemical RNA editing as a novel strategy in genetic restoration”, Chemical Biology & Drug Design, 86(5), 1242–1252 (2015), DOI: 10.1111/cbdd.12592

37. *Takashi Sakamoto, Daisaku Hasegawa, *Kenzo Fujimoto, “Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19F NMR and fluorescence”, Chemical Communications, 51(42), 8749–8752 (2015), DOI:10.1039/C5CC01995H

Highlighted as the Back Cover.

36. Takashi Sakamoto, Yuya Tanaka, *Kenzo Fujimoto, “DNA photo-cross-linking using 3-cyanovinylcarbazole modified oligonucleotide with threoninol linker”, Organic Letters, 17(4), 936–939 (2015), DOI:10.1021/acs.orglett.5b00035

[2014]

35. *Kenzo Fujimoto, Yu-ki Takematsu, Atsuo Shigeno, Mirei Furusawa, Takashi Sakamoto, “Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner”, Bioorganic & Medicinal Chemistry Letters, 24(16), 3736–3738 (2014), DOI:10.1016/j.bmcl.2014.07.002

34. Takashi Sakamoto, Atsuo Shigeno, Yuichi Ohtaki, *Kenzo Fujimoto, “Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides”, Biomaterials Science, 2(9), 1154–1157 (2014), DOI:10.1039/C4BM00117F

[2013]

33. *Kenzo Fujimoto, Asuka Yamada, Yoshinaga Yoshimura, Tadashi Tsukaguchi, Takashi Sakamoto, “Details of the ultrafast DNA photo-cross-linking reaction of 3‐cyanovinylcarbazole nucleoside: Cis–trans isomeric effect and the application for SNP-based genotyping”, Journal of the American Chemical Society, 135(43), 16161–16167 (2013), DOI:10.1021/ja406965f

32. *Kenzo Fujimoto, Satomi Kishi, Takashi Sakamoto, “Geometric effect on the photocrosslinking reaction between 3-cyanovinylcarbazole nucleoside and pyrimidine base in DNA/RNA heteroduplex”, Photochemistry and Photobiology, 89(5), 1095–1099 (2013), DOI:10.1111/php.12118

31. *Kenzo Fujimoto, Hiroki Yoshinaga, Yasumasa Yoshio, Takashi Sakamoto, “Quick and reversible photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside in a DNA triplex”, Organic & Biomolecular Chemistry, 11(31), 5065–5068 (2013), DOI:10.1039/C3OB40915E

Highlighted as the Inside Front Cover.

30. *Kenzo Fujimoto, Daiki Futamura, Takashi Sakamoto, “Diamine derivatives accelerate photochemical C→U transition in DNA double strand”, Chemistry Letters, 42(3), 289–291 (2013), DOI:10.1246/cl.2013.289

29. *Kenzo Fujimoto, Kaoru Konishi-Hiratsuka, Takashi Sakamoto, “Quick, selective and reversible photocrosslinking reaction between 5-Methylcytosine and 3-cyanovinylcarbazole in DNA double strand”, International Journal of Molecular Science, 14(3), 5765–5774 (2013), DOI:10.3390/ijms14035765

[2012]

28. Atsuo Shigeno, Takashi Sakamoto, Yoshinaga Yoshimura, *Kenzo Fujimoto, “Quick regulation of mRNA functions by a few seconds of photoirradiation”, Organic & Biomolecular Chemistry, 10(38), 7820–7825 (2012), DOI:10.1039/C2OB25883H

27. *Kenzo Fujimoto, Kaoru Hiratsuka-Konishi, Takashi Sakamoto, Tomoko Ohtake, Ken-ichi Shinohara, Yoshinaga Yoshimura, “Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole”, Molecular BioSystems, 8(2), 491–494 (2012), DOI:10.1039/C2MB05422A

26. Takashi Sakamoto, Takehiro Ami, Kenzo Fujimoto, “5-Methylcytosine selective photoligation using photoresponsive oligonucleotides containing various 5-vinyl-2’-deoxyuridines having an aromatic group”, Chemistry Letters, 41(1), 47–49 (2012), DOI:10.1246/cl.2012.47

[2011]

25. Takashi Sakamoto, Hikaru Hayakawa, *Kenzo Fujimoto, “Development of a potassium ion sensor for 19F magnetic resonance chemical shift imaging based on fluorine-labeled thrombin aptamer”, Chemistry Letters, 40(7), 720–721 (2011), DOI:10.1246/cl.2011.720

24. Takashi Sakamoto, Yu-ki Shimizu, Jun Sasaki, Hikaru Hayakawa, *Kenzo Fujimoto, “Signal turn-on probe for nucleic acid detection based on 19F nuclear magnetic resonance”, Bioorganic & Medicinal Chemistry Letters, 21(1), 303–306 (2011), DOI: 10.1016/j.bmcl.2010.11.013

[2010]

23. *Kenzo Fujimoto, Kaoru Konishi-Hiratsuka, Takashi Sakamoto, Yoshinaga Yoshimura, “Site-specific cytosine to uracil transition by using reversible DNA photo-crosslinking”, ChemBioChem, 11(12), 1661–1664 (2010), DOI:10.1002/cbic.201000274

22. *Kenzo Fujimoto, Kaoru Konishi-Hiratsuka, Takashi Sakamoto, Yoshinaga Yoshimura, “Site-specific photochemical RNA editing”, Chemical Communications, 46(40), 7545–7547 (2010), DOI:10.1039/C0CC03151H

[2009]

21. Yousuke Takaoka, Takashi Sakamoto, Shinya Tsukiji, Michiko Narazaki, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, *Itaru Hamachi, “Self-assembling nano-probes displaying off/on 19F NMR signals for protein detection and imaging”, Nature Chemistry, 1, 557–561 (2009), DOI:10.1038/nchem.365

20. Takashi Sakamoto, Masa-aki Inoue, Akio Ojida, *Itaru Hamachi, “Real-time fluorescence monitoring of GSK3beta-catalyzed phosphoryation by use of a BODIPY-based Zn(II)-Dpa chemosensor”, Bioorganic & Medicinal Chemistry Letters, 19(15), 4175–4177 (2009), DOI:10.1016/j.bmcl.2009.05.121

19. Akio Ojida, Takashi Sakamoto, Masa-aki Inoue, Sho-hei Fujishima, Guy Lippens, *Itaru Hamachi, “Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer’s disease patients”, Journal of the American Chemical Society, 131(18), 6543–6548 (2009), DOI:10.1021/ja9008369

18. Takashi Sakamoto, Akio Ojida, *Itaru Hamachi, “Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(II)-Dpa complexes”, Chemical Communications, (2), 141–152 (2009), DOI:10.1039/B812374H

[2008]

17. Takashi Sakamoto, Akio Kobori, *Akira Murakami, “Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe”, Bioorganic & Medicinal Chemistry Letters, 18(8), 2590–2593 (2008), DOI:10.1016/j.bmcl.2008.03.040

[2007]

16. Takashi Sakamoto, Akio Kobori, Masako Shigezawa, Yasutaka Amitani, Maiko Higuchi, *Akira Murakami, “Homogeneous fluorescence assays for RNA diagnosis by pyrene-conjugated 2′-O-methyloligoribonucleotides”, Nucleosides Nucleotides & Nucleic Acids, 26(10-12), 1659–1664 (2007), DOI:10.1080/15257770701615615

15. Ryuji Yokokawa, Soichiro Tamaoki, Takashi Sakamoto, Akira Murakami, *Susumu Sugiyama, “Transcriptome analysis device based on liquid phase detection by fluorescently labeled nucleic acid probes”, Biomedical Microdevices, 9(6), 869–875 (2007), DOI:10.1007/s10544-007-9100-4

14. Tatsuya Munaka, Hirohisa Abe, Masaki Kanai, Takashi Sakamoto, Hiroaki Nakanishi, Shuichi Shoji, Shinya Kimura, Taira Maekawa, *Akira Murakami, “Real-time monitoring of antibody secretion from B-cells on a microchip stimulated with a minute amount of mitogen”, Analyst, 132(6), 512–514 (2007), DOI:10.1039/B701049D

[2006]

13. Tatsuya Munaka, Hirohisa Abe, Masaki Kanai, Takashi Sakamoto, Hiroaki Nakanishi, Tetsuji Yamaoka, Shuichi Shoji, *Akira Murakami, “Monitoring cellular events in living mast cells stimulated with an extremely small amount of fluid on a microchip”, Japanese Journal of Applied Physics, 45, L634–L637 (2006), DOI:10.1143/JJAP.45.L634

12. Tatsuya Munaka, Hirohisa Abe, Masaki Kanai, Takashi Sakamoto, Akio Kobori, Hiroaki Nakanishi, Tetsuji Yamaoka, Shuichi Shoji, *Akira Murakami, “Real-time monitoring of antibody secretion from hybridomas on a microchip by time-resolved luminescence anisotropy analysis”, Analytical Biochemistry, 353, 1–6 (2006), DOI:10.1016/j.ab.2006.03.009

11. Takashi Sakamoto, Akio Kobori, *Akira Murakami, “Solid-phase detection of RNA using bispyreme-modified RNA probe”, Nucleic Acids Symposium Series, 50, 215–216 (2006), DOI:10.1093/nass/nrl107

10. Maiko Higuchi, Takashi Sakamoto, Akio Kobori, *Akira Murakami, “Properties of novel antisense oligonucleotides containing 2′-O-modified adenosine with a photo-reactive group”, Nucleic Acids Symposium Series, 50, 301–302 (2006), DOI:10.1093/nass/nrl150

[2005]

9. Takashi Sakamoto, Atsushi Mahara, Koichi Yamagata, Reiko Iwase, Tetsuji Yamaoka, *Akira Murakami, “Evaluation of dynamic features of Escherichia coli 16S ribosomal RNA in homogeneous physiological solution”, Biophysical Journal, 89, 4122–4128 (2005), DOI:10.1529/biophysj.105.062455

8. Takashi Sakamoto, Atsushi Mahara, Reiko Iwase, Tetsuji Yamaoka, *Akira Murakami, “Analytical method for estimation of kinetics of oligonucleotide/RNA hybridization using fluorescence depolarization spectroscopy”, Analytical Biochemistry, 340, 369–372 (2005), DOI:10.1016/j.ab.2004.11.037

7. Takashi Sakamoto, Atsushi Mahara, Akio Kobori, Tetsuji Yamaoka, *Akira Murakami, “Luminescence anisotropy-based detection of nucleic acids and proteins using long-lifetime Ru(II) complex as a luminescent label”, Nucleic Acids Symposium Series, 49, 203–204 (2005), DOI:10.1093/nass/49.1.203

[2004]

6. Takashi Sakamoto, Atsushi Mahara, Tatsuya Munaka, Koich Yamagata, Reiko Iwase, Tetsuji Yamaoka, *Akira Murakami, “Time-resolved luminescence anisotropy-based detection of immunoglobulin G using long-lifetime Ru(II) complex labeled protein A”, Analytical Biochemistry, 329, 142–144 (2004), DOI:10.1016/j.ab.2004.02.006

5. Naohiko Shimada, Atsushi Mahara, Takashi Sakamoto, Tetsuji Yamaoka, *Akira Murakami, “Transcriptome analysis using fluorescence-labeled oligonucleotide”, Nucleic Acids Symposium Series, 48, 301–302 (2004), DOI:10.1093/nass/48.1.301

[2003]

4. Atsushi Mahara, Reiko Iwase, Takashi Sakamoto, Tetsuji Yamaoka, Kazushige Yamana, *Akira Murakami,” Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy”, Bioorganic & Medicinal Chemistry, 11, 2783–2790 (2003), DOI:10.1016/S0968-0896(03)00227-X

3. Atsushi Mahara, Takashi Sakamoto, Tatsuya Munaka, Reiko Iwase, Tetsuji Yamaoka, *Akira Murakami, “Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence-labeled oligonucleotide”, Nucleic Acids Research, Supplement, 3, 73–74 (2003), DOI:10.1093/nass/3.1.73

[2002]

2. Atsushi Mahara, Reiko Iwase, Takashi Sakamoto, Kazushige Yamana, Tetsuji Yamaoka, *Akira Murakami, “Bispyrene-conjugated 2′-O-methyloligonucleotide as a highly specific RNA-recognition probe”, Angewandte Chemie, International Edition, 41, 3648–3649 (2002), DOI:10.1002/1521-3773(20021004)41:19<3648::AID-ANIE3648>3.0.CO;2-Y

[2001]

1. Takashi Sakamoto, Atsushi Mahara, Reiko Iwase, Tetsuji Yamaoka, *Akira Murakami, “Study on structure of ribosomal RNA by time-resolved luminescence anisotropy analysis”, Nucleic Acids Research, Supplement, 1, 143–144 (2001), DOI:10.1093/nass/1.1.143

Other Publications

REVIEW ARTICLEs

4. 坂本隆「核磁気共鳴を用いる生体分子の多成分同時一斉計測」月刊『BIO INDUSTRY』2018年10月号, Vol.35, No.10, 21–27 (2018)

3. 坂本隆、馬原淳、小堀哲生、村上章「蛍光分光法を用いたアンチセンス核酸のターゲット領域検索」Antisense, 9, 75–83 (2005)

2. 村上章、坂本隆、馬原淳「RNAの機能・構造解析に用いる螢光RNAプローブの開発」化学と生物, 41, 549–557 (2003)

1. 村上章、馬原淳、坂本隆「蛍光修飾核酸プローブによるRNAの構造解析」生体の化学, 53, 149–156 (2002)

BOOKs

4. Takashi Sakamoto, Kenzo Fujimoto “Photo-cross-linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-modified Nucleic Acids and Its Photo-induced Gene-silencing Activity in Cells” Synthesis of Therapeutic Oligonucleotides, Ed. Mitsuo Sekine and Satoshi Obika, Springer International Publishing (2018), 08 Dec. 2018, DOI: 10.1007/978-981-13-1912-9_10; ISBN: 978-981-13-1911-2.

3. Takashi Sakamoto, Kenzo Fujimoto “Photo-cross-linking Reaction in Nucleic Acids – Chemistry and Applications” Modified Nucleic Acids, Ed. Kazuhiko Nakatani and Yitzhak Tor, Springer International Publishing (2016), DOI: 10.1007/978-3-319-27111-8_7.

2. 坂本隆「DNAを検出する金ナノ粒子」続・洛中洛外ナノテクばなし, 京都ナノテククラスター(編), 日刊工業新聞社, pp.84–85 (2007)

1. 坂本隆、馬原淳、村上章「時間をキーワードにした遺伝子解析法－アンチセンス核酸の分子設計の試み」新しいDNAチップの科学と応用, 関根光雄(編), 講談社, pp.116–126 (2007)

MISC

10. 坂本隆「和歌山の端っこで核酸化学をつぶやく？」日本核酸化学会誌　Vol. 5, 20–22, (2021)

9. 坂本隆「抗菌作用を見てみよう！」おもしろ科学実験室（工学のふしぎな世界） https://www.mirai-kougaku.jp/laboratory/pages/210305.php (2021)

8. 坂本隆「核磁気共鳴を用いる生体分子の多成分同時一斉計測」月刊BIO INDUSTRY, Vol.35, No.10, 21–27 (2018)

7. 坂本隆「DNA 捕捉・放出能力をもつ多機能性ペプチド・ゲル・リポソームの創出」新学術領域研究「分子ロボティクス」, News Letter No. 17, p16 (2016)

6. 坂本隆「DNA 捕捉・放出能力をもつ新規高分子材料等の開発」新学術領域研究「分子ロボティクス」, News Letter No. 11, p11 (2015)

5. 坂本隆「気になった論文」日本化学会フロンティア生命化学研究会, 生命化学研究レター No.47(February), 28–30 (2015)

4. 坂本隆「分子ロボット創製に向けたDNA・RNAの光操作」新学術領域研究「分子ロボティクス」, News Letter No. 7, p13 (2014)

3. 坂本隆、馬原淳、小堀哲生、村上章「蛍光分光法を用いたアンチセンス核酸のターゲット領域検索」Antisense, 9, 75–83 (2005)

2. 村上章、坂本隆、馬原淳「RNAの機能・構造解析に用いる螢光RNAプローブの開発」化学と生物, 41, 549–557 (2003)

1. 村上章、馬原淳、坂本隆「蛍光修飾核酸プローブによるRNAの構造解析」生体の化学, 53, 149–156 (2002)

PATENTs

12. 坂本隆「＊＊＊＊＊＊＊＊」特許出願：2020-206368（2020.12.11）出願人：国立大学法人和歌山大学

11. 坂本隆「アミノ酸分析法」特許出願：2016–173792（2016.9.6）特許公開：2018-39747（2018.3.15）　出願人：国立大学法人和歌山大学（国立大学法人北陸先端科学技術大学院大学から譲渡 2017.3.14）

10. 坂本隆、藤本健造「含フッ素化合物、それを用いる核酸検出方法」特許出願：2015–44611（2015.3.6）特許公開：2016-164130（2016.9.8）　出願人：国立大学法人北陸先端科学技術大学院大学

9. 藤本健造、坂本隆、大江美成子「核酸中の塩基を変換する方法、及び核酸塩基変換剤」特許出願：2014–073943（2014.3.31）特許公開：2015-195736（2015.11.9）　出願人：国立大学法人北陸先端科学技術大学院大学

8. 藤本健造、坂本隆、田中佑弥「光クロスリンク能を有する光応答性ヌクレオチドアナログ」特許出願：2013–070381（2013.3.28）特許出願：2016-41446（2016.3.3）特許公開：2016-145229（2016.8.12）　出願人：国立研究開発法人科学技術振興機構

7. 寺崎浩司、今野玄理、島津光伸、藤本健造、坂本隆「光を用いた核酸の増幅抑制方法および高感度な選択的核酸増幅方法」特許出願：PCT/JP2011/070579（2011.9.9）出願人：三菱化学メディエンス株式会社

6. 中山雅人、荻野雅之、藤本健造、坂本隆「標的塩基配列の識別方法」特許出願：2010–79023（2010.3.30）特許公開：2011–206009（2011.10.20）出願人：凸版印刷株式会社、国立大学法人北陸先端科学技術大学院大学

5. 浜地格、坂本隆、山内文生「含フッ素化合物、それを用いる生体分子の検出方法」特許出願：2009–58775（2009.03.11）特許公開：2010–53116（2010.3.11）出願人：国立大学法人京都大学、キャノン株式会社

4. 浜地格、王子田彰夫、坂本隆、井上雅晶、山内文生、矢野哲哉、吉村公博「多点リン酸化ペプチド（タンパク）認識化合物、それを用いる検出方法」特許出願：2009–046253（2009.2.27）特許公開：2009–280567（2009.12.3）出願人：国立大学法人京都大学、キャノン株式会社

3. 村上章、坂本隆、繁澤麻紗子「蛍光標識オリゴヌクレオチドプローブ」特許出願：2006–039535 (2006.2.16) 特許公開：2007–215477（2007.8.30）出願人：国立大学法人京都工芸繊維大

2. 村上章、務中達也、阿部浩久、坂本隆「偏光解消法による生体高分子のスクリーニング方法及びそれに用いる反応容器」特許出願：2005–034972 (2005.2.10) 特許公開：2006–220566（2006.8.24）特許第4475525号(P4475525) 出願人：国立大学法人京都工芸繊維大学、株式会社島津製作所

1. 村上章、岩瀬礼子、馬原淳、坂本隆、山名一成、山岡哲二「蛍光ＲＮＡプローブ」特許出願：2002–244724 (2002.8.26) 特許公開：2004–81057（2004.3.18）出願人：関西ティー・エル・オー株式会社