The research work on "Nanoscale Surface Engineering Laboratory" at my Centre of Applied Nanosciences employ various physical as well as chemical methods to tailor the wettability and adhesion behaviour of the surfaces. Such wettability tailored surfaces are then explored for photonics as well as microfluidic applications. In a collaborative with Tata Institute of Fundamental Research, India, we demonstrated that the femtosecond laser patterning can tailor the surface wettability and consequently can control the orientation of biological cells [1]. By chemically and physically modified the surface wettability behaviour, the control over the water and air bubble adhesion behaviour was demonstrated [2-4]. Contrary to conventional wisdom, the superhydrophobic as well as underwater superaerophobic surfaces wwas shown on the same surface via [3]. In a recent work, we showed the utilization of an air-bubble at the liquid-air interface for the transport and assembly of particles [5-6]. Further, we demonstrated that by exploring the advantage of superhydrophobic and plasmonic Raman signal enhancement, it is possible to fabricate superhydrophobic SERS substrate that allow femtomolar detection of analyte molecules [7]. Further work in exploring the biological and spectroscopic applications of wettability tailored surfaces are in progress [8-11].