Publications

First-authored/Corresponding-authored publications

1. Yoon, Y., Song, S*. Structural insights into the lipopolysaccharide transport (Lpt) system as a novel antibiotic target. J Microbiol. 62(4):261-275 (2024).

2. Song, S., Hong, S., Jang, J., Yeom, J. H., Park, N., Lee, J., Lim, Y., Jeon, J. Y., Choi, H. K., Lee, M., Ha, N. C., Lee, K. Functional implications of hexameric assembly of RraA proteins from Vibrio vulnificus. PLoS One 12, e0190064 (2017).

3. Park, N.*, Song, S.*, Choi, G., Jang, K. K., Jo, I., Choi, S. H., Ha, N. C. Crystal Structure of the Regulatory Domain of AphB from Vibrio vulnificus, a Virulence Gene Regulator. Mol. Cells. 40, 299–306 (2017). (*: Co-first author)

4. Kim, J. S.*, Song, S.*, Lee, M., Lee, S., Lee, K., Ha, N. C. Crystal Structure of a Soluble Fragment of the Membrane Fusion Protein HlyD in a Type I Secretion System of Gram-Negative Bacteria. Structure 24, 477–485 (2016). (*: Co-first author)

5. Song, S., Lee, B., Yeom, J. H., Hwang, S., Kang, I., Cho, J. C., Ha, N. C., Bae, J., Lee, K., Kim, Y. H. An MdsABC-mediated pathway for pathogenicity in Salmonella enterica Serovar Typhimurium. Infect. Immun. 83, 4266–4276 (2015).

6. Song, S., Kim, J. S., Lee, K., Ha, N. C. Molecular architecture of the bacterial tripartite multidrug efflux pump focusing on the adaptor bridging model. J. Microbiol. 53, 355–364 (2015)

7. Song, S., Hwang, S., Lee, S., Ha, N. C., Lee, K. Interaction Mediated by the Putative Tip Regions of MdsA and MdsC in the Formation of a Salmonella-Specific Tripartite Efflux Pump. PLoS One 9, e100881 (2014). 

8. Kim, D.*, Song, S.*, Lee, M., Go, H., Shin, E., Yeom, J. H., Ha, N. C., Lee, K., Kim, Y. H. Modulation of RNase E activity by alternative RNA binding sites. PLoS One 9, e90610 (2014). (*: Co-first author)

9. Lee, S.*, Song, S.*, Lee, M., Hwang, S., Kim, J. S., Ha, N. C., Lee, K. Interaction between the α-barrel tip of Vibrio vulnificus TolC homologs and AcrA implies the adapter bridging model. J. Microbiol. 52, 148–153 (2014). (*: Co-first author)

10. Xu, Y.*, Song, S.*, Moeller, A., Kim, N., Piao, S., Sim, S. H., Kang, M., Yu, W., Cho, H. S., Chang, I., Lee, K., Ha, N. C. Functional implications of an intermeshing cogwheel-like interaction between TolC and MacA in the action of macrolide-specific efflux pump MacAB-TolC. J. Biol. Chem. 286, 13541–13549 (2011). (*: Co-first author)

Co-authored publications

1. Dimitrova, V. S., Song, S., Karagiaridi, A., Marand, A., Pinkett, H. W. Detergent Alternatives: Membrane protein purification using synthetic nanodisc polymers. Methods Mol Biol. In: Mus-Veteau, I. (eds) Heterologous Expression of Membrane Proteins. Methods in Molecular Biology, vol 2507. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2368-8_20 (2022).

2. Moore, C., Go, H., Shin, E., Ha, H. J, Song, S., Ha, N. C., Kim, Y. H., Cohen, S. N.,, Lee, K. Substrate-dependent effects of quaternary structure on RNase E activity. Genes Dev. 35(3-4):286-299 (2021). 

3. Jo, I., Hong, S., Lee, M., Song, S., Kim, J. S., Mitra, A. K., Hyun, J., Lee, K., Ha, N. C. Stoichiometry and mechanistic implications of the MacAB-TolC tripartite efflux pump. Biochem. Biophys. Res. Commun. 494, 668–673 (2017).

4. Tanaka, K. J., Song, S., Mason, K., Pinkett, H. W. Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis. Biochim. Biophys. Acta Biomembr. 1860, 868–877 (2018).

5. Park, N., Heo, J., Song, S., Jo, I., Lee, K., Ha, N. C. Crystal structure of Streptomyces coelicolor RraAS2, an unusual member of the RNase E inhibitor RraA protein family. J. Microbiol. 55, 388–395 (2017). 

6. Jeong, H., Kim, J.-S., Song, S., Shigematsu, H., Yokoyama, T., Hyun, J., Ha, N.-C. Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC. Structure 24, 272-276 (2016).

7. Heo, J., Kim, D., Joo, M., Lee, B., Seo, S., Lee, J., Song, S., Yeom, J. H., Ha, N. C., Lee, K. RraAS2 requires both scaffold domains of RNase ES for high-affinity binding and inhibitory action on the ribonucleolytic activity. J. Microbiol. 54, 660–666 (2016).

8. Park, Y. H., Um, S. H., Song, S., Seok, Y. J., Ha, N. C. Structural basis for the sequestration of the anti-σ70 factor Rsd from σ70 by the histidine-containing phosphocarrier protein HPr. Acta Cryst. D Biol. Crystallogr. 71, 1998–2008 (2015). 

9. Kim, J. S., Jeong, H., Song, S., Kim, H. Y., Lee, K., Hyun, J., Ha, N. C. Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode. Mol. Cells 38, 180–186 (2015). 

10. Jo, I., Chung, I. Y., Bae, H. W., Kim, J. S., Song, S., Cho, Y. H., Ha, N. C. Structural details of the OxyR peroxide-sensing mechanism. Proc. Natl. Acad. Sci. U.S.A. 112, 6443–6448 (2015). 

11. Lee, S., Song, S., Lee, K. Functional analysis of TolC homologs in Vibrio vulnificus. Curr. Microbiol. 68, 729–734 (2014). 

12. Lee, M., Kim, H. L., Song, S., Joo, M., Lee, S., Kim, D., Hahn, Y., Ha, N. C., Lee, K. The α-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC. J. Microbiol. 51, 154–159 (2013). 

13. Lee, M., Jun, S. Y., Yoon, B. Y., Song, S., Lee, K., Ha, N. C. Membrane fusion proteins of type I secretion system and tripartite efflux pumps share a binding motif for TolC in gram-negative bacteria. PLoS One 7, e40460 (2012). 

14. Xu, Y., Lee, M., Moeller, A., Song, S., Yoon, B. Y., Kim, H. M., Jun, S. Y., Lee, K., Ha, N. C. Funnel-like hexameric assembly of the periplasmic adapter protein in the tripartite multidrug efflux pump in gram-negative bacteria. J. Biol. Chem. 286, 17910–17920 (2011). 

15. Xu, Y., Sim, S. H., Song, S., Piao, S., Kim, H. M., Jin, X. L., Lee, K., Ha, N. C. The tip region of the MacA alpha-hairpin is important for the binding to TolC to the Escherichia coli MacAB-TolC pump. Biochem. Biophys. Res. Commun. 394, 962–965 (2010).