Diabetes and metabolic disorders significantly advance vascular complications such as cardiovascular disease, diabetic wound healing and retinopathy. Emerging evidence suggest that epigenetic factors and key long non-coding RNAs (lncRNAs) triggered by changing lifestyles and environment are new players in these pathologies. However, the epigenetic mechanisms involved and the role of lncRNAs in diabetes and its complications are still not well understood. The Diabetic Vascular Complications lab at IISER-Mohali will investigate the role of epigenetic regulators (enhancers/super-enhancers and lncRNAs) in vascular smooth muscle cell and macrophage function, that are critical cell types associated with major diabetic vascular complications.