Axon Regeneration and Neuronal Aging
Neurons extend axons and form synapses to communicate with distant cells. These structures make neurons face unique challenges, including supplying adequate materials to the sub-cellular area away from the cell body and maintaining structure against damage. Neurons also face particular challenges during aging because the aging condition can increase the risk of neuronal damage that can be caused by traumatic injury, stroke, and some age-associated neurodegenerative disorders. Axon regeneration is one of the essential steps in restoring the function of the damaged neurons.
Our long-term research goal is to understand how the nervous system maintains its function and integrity in response to aging and injury.
GABA motor neuron 24 after axotomy. Axon injury increases mitochondrial density
Arrowheads indicate mito::mCherry. Aritesks indicate the proximal tip of injured axon.