Mitochondrial Response to Environmental Toxicants
Mitochondria serve as crucial intracellular targets for a wide range of environmental toxicants, including pollutants, heavy metals, and pesticides. Exposure to these toxins, whether over a short or long duration, can elicit substantial alterations in mitochondrial morphology, dynamics, physiological properties, activity, homeostasis, and interplay with other intracellular organelles. Importantly, the resulting mitochondrial dysfunction caused by environmental toxicity can have significant implications for an organism's overall health and survival.
To investigate the effects of environmental contaminants on mitochondria and their subsequent impact on an organism's well-being and lifespan, we employ the nematode C. elegans as an in vivo model. Through this model system, we can assess and elucidate the mechanisms underlying mitochondrial responses to environmental toxicants and their consequences.