Rourke Laboratory

G-Protein Coupled Receptors Research

Department of Chemistry and Biochemistry, Mount Allison University


The Rourke Lab is located at Mount Allison University in Sackville, New Brunswick, Canada. Our lab has a variety of research interests including G protein-coupled receptors (GPCR) and their cell signaling, cell function, as well as aspects of endocrinology including hormone secretion with implications in obesity and diabetes.

GPCR signal transduction, cell function and hormone secretion research

Dr. Jillian L. Rourke

Our research is conducted by qualified and passionate undergraduate students, led by Dr. Jillian L. Rourke, Assistant Professor, Department of Chemistry and Biochemistry, Mount Allison University.


  • Ph.D. Pharmacology, Dalhousie University, 2015. Investigating differential signaling and functions of the chemerin receptors CMKLR1 and GPR1
  • B.Sc. Honours, Biochemistry and Molecular Biology, Dalhousie University, 2009. Seeking a function for the yeast Niemann-Pick C-related gene (NCR1)

Academic Experience

  • Assistant Professor, Chemistry and Biochemistry, Mount Allison University 2018
  • CIHR Postdoctoral Fellow, SunnyBrook Research Institute, Toronto, Canada, 2015-2018 Discovering novel regulators of human beta cell proliferation

Currently, we are focusing on the discovery of unknown endogenous ligands for orphan GPCRs through high-throughput screening PRESTO-Tango assays. We look forward to deorphanizing as many receptors as possible through this method.